1. Study the effects of zonisamide on fine structure of rabbit basilar artery and hippocampus in rabbit subarachnoid hemorrhage model.
- Author
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Demirci AY, Seckin H, Besalti O, Arikok AT, Yigitkanli T, Caliskan M, Yigitkanli K, and Bavbek M
- Subjects
- Animals, Basilar Artery pathology, Disease Models, Animal, Hippocampus blood supply, Male, Rabbits, Zonisamide, Basilar Artery drug effects, Hippocampus drug effects, Isoxazoles therapeutic use, Subarachnoid Hemorrhage drug therapy, Vasospasm, Intracranial drug therapy
- Abstract
Background: In this study, we investigated the effect of a novel antiepileptic drug, zonisamide (ZNS), on the basilar artery and hippocampus in a rabbit subarachnoid hemorrhage (SAH) model., Methods: Three groups of New Zealand white rabbits were used: a sham (non-SAH) group, an SAH + saline group, and SAH + drug treatment group that received ZNS. In the treatment group, the subjects were given ZNS for 3 days after the SAH. Hippocampal sections were evaluated for neural tissue degeneration. Basilar artery lumen areas and arterial wall thickness were also measured in all groups., Results: The mean luminal area of the SAH + ZNS was significantly greater than the SAH + saline group. In addition, the arterial wall thickness of SAH + ZNS group was significantly thinner than the SAH + saline group. The neuronal degeneration scores of the hippocampal CA1 regions in the SAH + ZNS group were significantly lower than the SAH + saline treatment animals., Conclusions: These results indicate that ZNS has a vasodilatatory effect on the basilar artery and a neuronal protective effect in the CA1 region of the hippocampus in a rabbit SAH model.
- Published
- 2013
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