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High levels of cholesterol in the blood can lead to various health problems, including atherosclerosis, stroke, coronary heart disease, and hypertension. One treatment option for individuals with hypercholesterolemia is simvastatin. In addition to using simvastatin, herbal remedies can also be consumed. One herbal plant that can help lower high cholesterol levels is the extract of Ashitaba leaves (Angelica keiskei). One of the components in Ashitaba extract is xanthoangelol E, along with Ashitaba chalcones, which can reduce cholesterol synthesis. The aim of this study is to determine the effect of Ashitaba extract (Angelica keiskei) on the cholesterol levels of Wistar rats (Rattus norvegicus) that were given a high-fat diet. This study also conducted a computational lethal dose test. The population for this study consisted of male Wistar strain white rats, with a sample size of 30 individuals. Data analysis was performed using One Way ANOVA statistical tests. The results showed that administration of Ashitaba extract at doses of 150 mg/kg body weight, 300 mg/kg body weight, and 600 mg/kg body weight did not affect the cholesterol levels of Wistar rats on a high-fat diet. This was evidenced by the ANOVA test results, which yielded a significance value of 0.761, greater than 0.05. Further research on the toxic effects of Ashitaba extract is needed for future studies. [ABSTRACT FROM AUTHOR]