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Hyperhomocysteinemia is a substantial risk factor for heart disease unrelated to diet. Many clinical and epidemiological research has found a link between elevated plasma homocysteine and the development of atherosclerosis in people. This investigation aims to identify the typical homocysteine levels in the blood. As well as lipids in healthy Iraqi control groups and to compare them with atherosclerotic patients. Blood samples were taken from 62 healthy control subjects (42 male and 20 female), 68 patients suffering from premature signs of Ischemic heart disease admitted to the cardiac care unit (38 male and 30 female), and (15) patients suffering from hyperhomocysteinemia. These participants were divided into five groups based on their age. The blood samples from these groups were analyzed to measure plasma total homocysteine, total serum cholesterol, triglycerides, VLDL, LDL, and HDL. All control subjects have normal fasting blood glucose, serum lipids also blood pressure. According to the findings, patients' plasma total homocysteine levels were considerably higher. Had previous signs of atherosclerosis compared to control groups. The study has also classified plasma homocysteine according to the severity of hyperhomocysteinemia. The findings show that intermediate hyperhomocysteinemia is more frequent (32 patients; 47.05 %) as compared to moderate (25 patients; 36.77%) and severe hyperhomocysteinemia (11 patients; 16.18%). The results also showed that the lipid profile of The patient group was substantially higher than the control group., except for HDL-cholesterol, which has been significantly lower than in the control group. [ABSTRACT FROM AUTHOR]