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Hiccups are involuntary and intermittent contraction of the diaphragm and the intercostal muscles. Hiccup is usually a self-limited disorder, but it is needed to use physical interventions and pharmacological treatment for some intractable hiccups. In medical literature some cases, treated with drugs that effect on serotonergic system, are described for intractable hiccups. In this case, we aim to present a hiccup case secondary to selective serotonine reuptake inhibitory drugs (paroxetine, fluoxetine and sertraline respectively) in a 28-year-old man with major depression with psychotic features. [ABSTRACT FROM AUTHOR]