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Start Over Author "Matteoli, B" Topic hhv-8
5 results on '"Matteoli, B"'

3. Genotipi di HHV-8 in Sardegna

Author

Matteoli, B, Moriconi, F, Masala, Mv, Montesu, Ma, Satta, R, Cuccuru, Ma, Santarelli, R, Faggioni, A, Angeloni, A, Cottoni, F, and CECCHERINI-NELLI, Luca

Subjects
HHV-8, Sardegna, Genotipi
Published
2006

4. Modulation of gene expression in Kaposi’s sarcoma-associated herpesvirus-infected lymphoid and epithelial cells

Author

Lisa Fusetti, Giulia Ciccarese, Francesco Broccolo, B Matteoli, Luca Ceccherini-Nelli, Susanna Esposito, A. Scaccino, Francesco Drago, Francesco Formica, Massimo Oggioni, Matteoli, B, Broccolo, F, Oggioni, M, Scaccino, A, Formica, F, Ciccarese, G, Drago, F, Fusetti, L, Esposito, S, and Ceccherini Nelli, L

Subjects
0301 basic medicine, Cell type, Cell, Kaposi's sarcoma, Inflammation, Biology, medicine.disease_cause, medicine.disease, 03 medical and health sciences, 030104 developmental biology, medicine.anatomical_structure, Virology, Gene expression, Immunology, gene expression, medicine, Kaposi's sarcoma-associated herpesvirus, medicine.symptom, Signal transduction, Gene, HHV-8
Abstract

Aim: To evaluate the gene expression changes that occur soon after the active infection of two susceptible cell types with human herpesvirus 8 (HHV-8). Materials & methods: The expression profile of 282 human genes involved in the inflammatory process was investigated in HHV-8 A1 or C3 subtype-infected and mock-infected human epithelial cells and lymphoid cells. Results: The HHV-8-induced transcriptional profiles in the epithelial and lymphoid cells were very different. A robust increase in the expression was found in genes belonging to different categories, especially the categories of inflammation response and signal transduction. Conclusion: These results indicate that during early infection, HHV-8 induces a variety of cell type-specific processes, thus providing infection signatures useful as potential targets for therapeutic intervention.

Published
2016

5. In vivo and in vitro evidence for an association between the route-specific transmission of HHV-8 and the virus genotype

Author

A. Scaccino, Alberto Faggioni, Antonio Angeloni, Francesco Broccolo, Luca Ceccherini-Nelli, Francesca Cottoni, B Matteoli, Matteoli, B, Broccolo, F, Scaccino, A, Cottoni, F, Angeloni, A, Faggioni, A, and Ceccherini Nelli, L

Subjects
Male, Saliva, Genotype, viruses, Molecular Sequence Data, Biology, Peripheral blood mononuclear cell, classic ks, Virus, Cell Line, hhv-8 genotype, HEK293 Cell, Virology, Humans, Seroprevalence, Amino Acid Sequence, Sarcoma, Kaposi, Phylogeny, hhv-8, Epithelial Cell, Herpesviridae Infection, cellular tropism, transmission, virus diseases, Epithelial Cells, Herpesviridae Infections, Sequence Analysis, DNA, Viral Load, Viral Tropism, HEK293 Cells, Infectious Diseases, Italy, Cell culture, DNA, Viral, Herpesvirus 8, Human, Immunology, Leukocytes, Mononuclear, Tissue tropism, Female, Viral load, Human
Abstract

The study was performed to determine if there is an association between the genotype and transmission of HHV-8 types A and C. These HHV-8 subtypes are prevalent in the area of North of Sardinia, which is an island off west Italy's mainland that has a high HHV-8 seroprevalence (35%). Blood and saliva samples from 30 patients with classic Kaposi's sarcoma who were lifetime residents of North Sardinia were analyzed to identify the HHV-8 genotype and quantitate the viral load. Genotype A, especially A1 subtype, was found more frequently (9/30 patients) and had a significantly higher viral load in saliva compared to blood (P = 0.029), where type C was found more frequently but with a viral load lower than 103 copies/ml. To determine if there is a correlation between the viral genotype and cellular tropism, type A1 and C3 HHV-8 viral particles were obtained from cell lines BCBL1 and BC3 infected chronically with HHV-8 A1 and C3 genotypes respectively and used to infect HEK293 epithelial origin cells and PBMCs in vitro. The data indicate that the A1 HHV-8 genotype is tropic and replicates at higher levels in the epithelial cell lines. J. Med. Virol. 84:786–791, 2012. © 2012 Wiley Periodicals, Inc.

Published
2012

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