1. d-Idose, d-Iduronic Acid, and d-Idonic Acid from d-Glucose via Seven-Carbon Sugars.
- Author
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Liu Z, Jenkinson SF, Yoshihara A, Wormald MR, Izumori K, and Fleet GWJ
- Subjects
- Carbohydrate Conformation, Glucose chemistry, Heptoses chemistry, Hexoses chemistry, Iduronic Acid chemistry, Molecular Structure, Sugar Acids chemistry, Hexoses chemical synthesis, Iduronic Acid chemical synthesis, Sugar Acids chemical synthesis
- Abstract
A practical synthesis of the very rare sugar d-idose and the stable building blocks for d-idose, d-iduronic, and d-idonic acids from ido -heptonic acid requires only isopropylidene protection, Shing silica gel-supported periodate cleavage of the C6-C7 bond of the heptonic acid, and selective reduction of C1 and/or C6. d-Idose is the most unstable of all the aldohexoses and a stable precursor which be stored and then converted under very mild conditions into d-idose is easily prepared. more...
- Published
- 2019
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