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1. Nickel catalyzed alkylation of N-aromatic heterocycles with Grignard reagents through direct C-H bond functionalization.

Author

Xin PY, Niu HY, Qu GR, Ding RF, and Guo HM

Subjects
Alkylation, Catalysis, Molecular Structure, Heterocyclic Compounds chemistry, Nickel chemistry
Abstract

A novel protocol for nickel-catalyzed direct sp(2) C-H bond alkylation of N-aromatic heterocycles has been developed. This new reaction proceeded efficiently at room temperature using a Grignard reagent as the coupling partner. This approach provides new access to a variety of alkylated N-aromatic heterocycles which are potentially of great importance in medicinal chemistry.

Published
2012
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