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Your search keyword '"Grishakov, A. N."' showing total 2 results
Start Over Author "Grishakov, A. N." Topic heterocyclic compounds
2 results on '"Grishakov, A. N."'

1. Stereochemical features of addition of O- and C-nucleophiles to 5-(Het)aryl-2,3-dicyano-1-ethylpyrazinium salts.

Author

Verbitskii, E. V., Rusinov, G. L., Slepukhin, P. A., Grishakov, A. N., Ezhikova, M. A., Kodess, M. I., and Charushin, V. N.

Subjects
CATIONS, PYRAZINES, HETEROCYCLIC compounds, ENANTIOMERS, HIGH performance liquid chromatography, ORGANIC chemistry
Abstract

Stable σH-adducts of O- and C-nucleophiles were obtained with cations of 5-(het)aryl-2,3-dicyano-1-ethylpyrazinium, and their structure was investigated by X-ray diffraction analysis. Analytical separation was performed of 1,2-dihydropyrazines into individual enantiomers by means of HPLC on columns with chiral sorbents. [ABSTRACT FROM AUTHOR]

Published
2008
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2. Acylative kinetic resolution of racemic amines using N-phthaloyl-(S)-amino acyl chlorides

Author

Gruzdev, Dmitry A., Levit, Galina L., Krasnov, Victor P., Chulakov, Evgeny N., Sadretdinova, Liliya Sh., Grishakov, Aleksandr N., Ezhikova, Marina A., Kodess, Mikhail I., and Charushin, Valery N.

Subjects
*CHEMICAL kinetics, *ACYLATION, *AMINES, *CHLORIDES, *QUINOLINE, *HETEROCYCLIC compounds, *COMPARATIVE studies, *CHIRALITY
Abstract

Abstract: A comparative study of the kinetic resolution of racemic 2-methyl-1,2,3,4-tetrahydroquinoline and 2,3-dihydro-3-methyl-4H-1,4-benzoxazine using N-phthaloyl-(S)-amino acyl chlorides as chiral acylating agents is described. Temperature and solvent effects on the stereochemical features have been examined. It has been found that N-phthaloyl-(S)-phenylalanyl and N-phthaloyl-(S)-2-phenylglycyl chlorides bearing aromatic substituents close to the stereogenic centre are more stereoselective acylating agents than N-phthaloyl-(S)-alanyl chloride. For the preparative kinetic resolution of racemic amines N-phthaloyl-(S)-phenylalanyl chloride proved to be the most appropriate chiral acylating agent. [Copyright &y& Elsevier]

Published
2010
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