1. Role of the suppressor of cytokine signaling 2 (SOCS2) during meningoencephalitis caused by Bovine herpesvirus 5 (BoHV-5).
- Author
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Aparecida Silva Barbosa A, Freitas Versiani A, Fonseca da Cunha Sousa L, Silva de Miranda A, Gasparini MR, Brant F, Silva DG, Luisa Quintino-de-Carvalho I, Marianetti Soriani F, Guimarães da Fonseca F, César Vasconcelos A, da Silva Barcelos L, Martins Teixeira M, Lúcio Teixeira A, Machado FS, Barbosa-Stancioli EF, and Rachid MA
- Subjects
- Animals, Brain immunology, Brain physiopathology, Cattle, Chemokine CCL5 genetics, Chemokine CXCL1 genetics, Cytokines genetics, DNA, Viral, Herpesviridae Infections immunology, Herpesviridae Infections physiopathology, Herpesviridae Infections virology, Herpesvirus 5, Bovine immunology, Interferon-alpha genetics, Interferon-beta genetics, Liver virology, Lung virology, Meningoencephalitis immunology, Meningoencephalitis physiopathology, Meningoencephalitis virology, Mice, Mice, Inbred C57BL, Polymerase Chain Reaction, Suppressor of Cytokine Signaling Proteins deficiency, Suppressor of Cytokine Signaling Proteins immunology, Brain virology, Herpesviridae Infections veterinary, Herpesvirus 5, Bovine genetics, Herpesvirus 5, Bovine pathogenicity, Meningoencephalitis metabolism, Suppressor of Cytokine Signaling Proteins genetics, Suppressor of Cytokine Signaling Proteins physiology
- Abstract
The role of suppressors of cytokine signaling (SOCS) in meningoencephalitis caused by Bovine herpesvirus 5 (BoHV-5) was evaluated by intracranial infection in C57BL/6 wild-type mice (WT) and SOCS2 deficient mice (SOCS2(-/-)). Both infected groups presented weight loss, ruffled fur and hunched posture. Additionally, infected SOCS2(-/-) mice showed swollen chamfer and progressive depression. Infected WT animals developed mild meningitis, characterized by infiltration of mononuclear cells. Moreover, viral DNA was detected in liver and lung from infected WT group. This group also showed elevated brain levels of IFN-γ, IL-10, CXCL1 and CCL5, when compared with non-infected WT animals. Brain inflammation was exacerbated in infected SOCS2(-/-) mice with widespread distribution of the virus and increased brain levels of TNF-α, IFN-γ, IL-10, IL-12, CXCL1 and CCL5, when compared with WT infected mice. Moreover, infected SOCS2 deficient mice exhibited reduced brain mRNA expression of IFNα and IFNβ and increased expression of mRNA of SOCS1, compared with infected WT mice. Taken together, our study provides an insight into the role of SOCS2 in modulating the immune response to BoHV-5 infection., (Copyright © 2016 Elsevier Ltd. All rights reserved.)
- Published
- 2016
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