1. Natural Killer Cell-Derived Interferon-γ Regulates Macrophage-Mediated Immunopathology During Viral Infection.
- Author
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Feng E, Monteiro JK, Portillo AL, Balint E, and Ashkar AA
- Subjects
- Humans, Killer Cells, Natural, Herpesvirus 2, Human, Macrophages, Interferon-gamma, Herpes Genitalis
- Abstract
Regulation of immune responses during viral infection is critical to preventing the development immunopathology that impairs host survival. Natural killer (NK) cells are well known for their antiviral functions that promote viral clearance; however, their roles in limiting immune-mediated pathology are still unclear. Using a mouse model for genital herpes simplex virus type 2 infection, we find that NK cell-derived interferon-γ directly counteracts interleukin-6-mediated matrix metalloproteases (MMPs) activity in macrophages to limit MMP-mediated tissue damage. Our findings uncover a key immunoregulatory function of NK cells during host-pathogen interactions that highlight the potential of NK cell therapy for treatment of severe viral infections., Competing Interests: Potential conflicts of interest. AAA holds a Tier 1 Canada Research Chair in Natural Immunity and NK Cell Function. EF and ALP are the recipients of CIHR Canadian Graduate Scholarship Doctoral Award. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed., (© The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Published
- 2023
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