6 results on '"Rijsdijk, Frühling V."'
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2. Heritability of the limbic networks
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Budisavljevic, Sanja, Kawadler, Jamie M., Dell'Acqua, Flavio, Rijsdijk, Frühling V., Kane, Fergus, Picchioni, Marco, McGuire, Philip, Toulopoulou, Timothea, Georgiades, Anna, Kalidindi, Sridevi, Kravariti, Eugenia, Murray, Robin M., Murphy, Declan G., Craig, Michael C., Catani, Marco, University of St Andrews. School of Medicine, and University of St Andrews. Population and Behavioural Science Division
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Adult ,Male ,Inheritance Patterns ,Twins ,diffusion tractography ,uncinate fasciculus ,fornix ,QH426 Genetics ,heritability ,behavioral disciplines and activities ,E-NDAS ,Heritability ,Young Adult ,Limbic system ,Cingulum ,limbic system ,Uncinate fasciculus ,Neural Pathways ,Humans ,Registries ,cingulum ,QH426 ,Cerebral Cortex ,Diffusion tractography ,Original Articles ,Middle Aged ,Diffusion Tensor Imaging ,nervous system ,RC0321 ,Female ,Nerve Net ,RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry ,psychological phenomena and processes - Abstract
This work was supported by the MRC UK (grant number G0400061) as the AIMS (Autism Imaging Multicentre Study) with support from the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust, King’s College London, and the Sackler Institute for Translational Neurodevelopment. Additional funding was provided by the European Autism Interventions—A Multicentre Study for Developing New Medications (EU-AIMS), which received support from the Innovative Medicines Initiative Joint Undertaking (grant agreement number 115300), including financial contributions from the EU Seventh Framework Programme (FP7/2007-2013), the European Federation of Pharmaceutical Industries and Associations companies in kind, Autism Speaks, NARSAD, The Stanley Foundation, Schizophrenia Research Trust and Psychiatry Research Trust. M.C. is the recipient of a Wellcome Trust Investigator Award (103759/Z/14/Z). Individual differences in cognitive ability and social behaviour are influenced by the variability in the structure and function of the limbic system. A strong heritability of the limbic cortex has been previously reported, but little is known about how genetic factors influence specific limbic networks. We used diffusion tensor imaging tractography to investigate heritability of different limbic tracts in 52 monozygotic and 34 dizygotic healthy adult twins. We explored the connections that contribute to the activity of three distinct functional limbic networks, namely the dorsal cingulum ('medial default-mode network'), the ventral cingulum and the fornix ('hippocampal-diencephalic-retrosplenial network') and the uncinate fasciculus ('temporo-amygdala-orbitofrontal network'). Genetic and environmental variances were mapped for multiple tract-specific measures that reflect different aspects of the underlying anatomy. We report the highest heritability for the uncinate fasciculus, a tract that underpins emotion processing, semantic cognition, and social behaviour. High to moderate genetic and shared environmental effects were found for pathways important for social behaviour and memory, for example, fornix, dorsal and ventral cingulum. These findings indicate that within the limbic system inheritance of specific traits may rely on the anatomy of distinct networks and is higher for fronto-temporal pathways dedicated to complex social behaviour and emotional processing. Publisher PDF
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- 2016
3. Age-related differences and heritability of the perisylvian language networks
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Budisavljevic, Sanja, Dell’Acqua, Flavio, Rijsdijk, Frühling V., Kane, Fergus, Picchioni, Marco, McGuire, Philip, Toulopoulou, Timothea, Georgiades, Anna, Kalidindi, Sridevi, Kravariti, Eugenia, Murray, Robin, Murphy, Declan G., Craig, Michael C., and Catani, Marco
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Heritability ,Lateralization ,Arcuate fasciculus ,Diffusion tensor tractography ,Network asymmetry ,Language - Abstract
Acquisition of language skills depends on the progressive maturation of specialized brain networks that are usually lateralized in adult population. However, how genetic and environmental factors relate to the age-related differences in lateralization of these language pathways is still not known. We recruited 101 healthy right-handed subjects aged 9–40 years to investigate age-related differences in the anatomy of perisylvian language pathways and 86 adult twins (52 monozygotic and 34 dizygotic) to understand how heritability factors influence language anatomy. Diffusion tractography was used to dissect and extract indirect volume measures from the three segments of the arcuate fasciculus connecting Wernicke’s to Broca’s region (i.e., long segment), Broca’s to Geschwind’s region (i.e., anterior segment), and Wernicke’s to Geschwind’s region (i.e., posterior segment). We found that the long and anterior arcuate segments are lateralized before adolescence and their lateralization remains stable throughout adolescence and early adulthood. Conversely, the posterior segment shows right lateralization in childhood but becomes progressively bilateral during adolescence, driven by a reduction in volume in the right hemisphere. Analysisofthetwinsampleshowedthatgeneticandsharedenvironmentalfactorsinfluencetheanatomyofthosesegmentsthatlateralizeearlier, whereas specific environmental effects drive the variability in the volume of the posterior segment that continues to change in adolescence and adulthood.Ourresults suggest that the age-related differences in the lateralization of thelanguageperisylvianpathwaysare related to the relative contribution of genetic and environmental effects specific to each segment.
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- 2015
4. The Relationship Between Neuroticism and Inflammatory Markers: A Twin Study.
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Sas, Arthur A., Rijsdijk, Frühling V., Ormel, Johan, Snieder, Harold, and Riese, Harriëtte
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TWIN studies , *NEUROTICISM , *BIOMARKERS , *INFLAMMATION , *C-reactive protein , *FIBRINOGEN , *IMMUNOGLOBULIN G , *HERITABILITY - Abstract
Introduction: Neuroticism is an important marker of vulnerability for both mental and physical disorders. Its link with multiple etiological pathways has been studied before. Inflammatory markers have been demonstrated to predict similar mental and physical disorders as neuroticism. However, currently no study has focused on the shared genetic background of neuroticism and inflammatory markers. In the present study we will focus on the phenotypic and genetic relationship between neuroticism and three commonly used inflammatory markers: C-reactive protein (CRP), fibrinogen and Immunoglobulin-G (IgG). Material and Methods: The study was conducted in 125 Dutch female twin pairs. For each participant, four different neuroticism scores were available to calculate a neuroticism composite score that was used in the statistical analyses. Blood samples for inflammatory marker determination were taken after an overnight fast. Heritabilities, phenotypic and genetic correlations were estimated using bivariate structural equation modeling. Results: Heritabilities are fair for neuroticism (0.55), CRP (0.52) and fibrinogen (0.67) and moderate for IgG (0.43). No significant phenotypic or genetic correlations were found between neuroticism and the inflammatory markers. Interaction models yielded no moderation of the genetic and environmental pathways in the regulation of inflammatory markers by neuroticism. Conclusion: Substantial heritabilities were observed for all variables. No evidence was found for significant shared (or moderation of) genetic or environmental pathways underlying neuroticism and inflammatory status. [ABSTRACT FROM PUBLISHER]
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- 2014
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5. Neuroticism and Morning Cortisol Secretion: Both Heritable, But No Shared Genetic Influences.
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Riese, Harriëtte, Rijsdijk, Frühling V., Rosmalen, Judith G. M., Snieder, Harold, and Ormel, Johan
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NEUROSES , *HYDROCORTISONE , *PHENOTYPES , *ETIOLOGY of diseases , *HERITABILITY , *STATISTICAL hypothesis testing , *QUANTITATIVE research , *PATHOLOGICAL psychology - Abstract
Neuroticism is widely used as an explanatory concept in etiological research of psychopathology. To clarify what neuroticism actually represents, we investigated the phenotypic and genetic relationship between neuroticism and the morning cortisol secretion. In the current classic twin study, 125 female twin pairs (74 monozygotic and 51 dizygotic pairs) participated. For each participant, 4 different neuroticism scores were available to calculate a neuroticism composite score that was used in the statistical analyses. The morning cortisol secretion was assessed by 4 salivary samples in the 1st hour after awakening. Significant genetic influences for the neuroticism composite score (55%), and each of the 4 cortisol samples (52%–69%) were found. There was no phenotypic or genotypic relationship between neuroticism and morning cortisol secretion. Although neuroticism and cortisol were both heritable traits, they did not share any genetic influences. [ABSTRACT FROM AUTHOR]
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- 2009
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6. The narrow-sense and common single nucleotide polymorphism heritability of early repolarization.
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Bastiaenen, Rachel, Nolte, Ilja M., Munroe, Patricia B., Riese, Harriëtte, Nelson, Christopher, O'Connor, Henry, Gang, Yi, Warren, Helen R., Cabrera, Claudia, Reinhard, Wibke, Hengstenberg, Christian, Rijsdijk, Frühling V., Spector, Tim, Snieder, Harold, Samani, Nilesh J., Jamshidi, Yalda, and Behr, Elijah R.
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FAMILIES , *CARDIAC arrest , *SINGLE nucleotide polymorphisms - Abstract
Abstract Background Early repolarization (ER) is a risk marker for sudden cardiac death. Higher risk is associated with horizontal/descending ST-segment ER in the inferior or inferolateral ECG leads. Studies in family cohorts have demonstrated substantial heritability for the ER pattern, but genome-wide association studies (GWAS) have failed to identify statistically significant and replicable genetic signals. Methods and results We assessed the narrow-sense and common single nucleotide polymorphism (SNP) heritability of ER and ER subtypes using ECG data from 5829 individuals (TwinsUK, BRIGHT and GRAPHIC cohorts). ER prevalence was 8.3%. In 455 monozygous vs 808 dizygous twin pairs, concordances and twin correlations for ER subtypes (except horizontal/descending ST-segment ER) were higher and familial resemblance (except notched ER) was significant. Narrow-sense heritability estimates derived from 1263 female twin pairs using the structural equation program Mx ranged from 0.00–0.47 and common SNP heritability estimates derived from 4009 unrelated individuals of both sexes using Genome-wide Restricted Maximum Likelihood (GREML) ranged from 0.00–0.36, but none were statistically significant. Conclusion From our data, ER shows limited genetic predisposition. There appears to be significant environmental influence and these modest narrow-sense and common SNP heritability estimates may explain why previous GWAS have been unsuccessful. Highlights • Cohort studies showed ER was heritable, but GWAS failed to find genetic signals. • We assessed ER and ER subtype heritability using twin studies and genotyping data. • For most ER subtypes, twin concordances and correlations were higher. • But narrow-sense and common SNP heritabilities were not significant. • Limited genetic predisposition may explain why previous GWAS were unsuccessful. [ABSTRACT FROM AUTHOR]
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- 2019
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