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Background: Few studies of the relationship between residential proximity to agricultural pesticide applications and pesticide levels in the home have incorporated crop location or wind direction. We evaluated the relationship between agricultural pesticide applications using the California Pesticide Use Reporting (CPUR) database and pesticide concentrations in carpet dust accounting for land use and wind direction., Methods: We measured concentrations (ng/g) of seven herbicides and two fungicides in carpet dust samples from 578 California homes (2001-2007). We created three metrics by computing the density (kg/km 2 ) of use of each pesticide reported in CPUR within 0.5-, 1-, 2-, and 4-km buffers around homes 180- and 365-days before sampling (CPUR metric). We apportioned applications to the crop area within the buffers (CROP-A metric) and weighted CPUR applications by the proportion of days that the home was within ±45° of the downwind direction (W-CPUR metric). We modeled natural-log concentrations (Tobit regression) and dust detections (logistic regression) adjusting for season/year, occupation, and home/garden use., Results: Detections were >90 % for glyphosate, 2,4-D, and simazine. Detection rates and dust concentrations increased with increasing CPUR densities for all herbicides and one fungicide. Compared to homes without applications within 4 km, the highest tertile of 365-day glyphosate use was associated with ∼100 % higher concentrations (CPUR T3>9.2kg/km 2 % change  = 110, 95 %CI = 55, 183; CROP-A T3>13.4kg/km 2 % change  = 144, 95 %CI = 81, 229; and W-CPUR T3>2.1kg/km 2 % change  = 102, 95 %CI = 50, 171). The highest density tertiles of 2,4-D, simazine, and trifluralin were associated with 2- to 6-times higher concentrations, respectively; that was similar across metrics. Across all metrics, agricultural use of dacthal, dicamba, and iprodione were associated with 5- to 10-times higher odds of dust detections. Associations were unclear for 2-methyl-4-chlorophenoxyacetic acid and null for chlorothalonil., Conclusions: Agricultural herbicide and fungicide use was an important determinant of indoor contamination within 4 km of homes. Accounting for crops and wind direction did not substantially change these relationships., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Published by Elsevier Ltd.)

The honey bee is the most common and important managed pollinator of crops. In recent years, honey bee colonies faced high mortality for multiple causes, including land-use change and the use of plant protection products (hereafter pesticides). This work aimed to explore how contamination by pesticides of pollen collected by honey bees was modulated by landscape composition and seasonality. We placed two honey bee colonies in 13 locations in Northern Italy in contrasting landscapes, from which we collected pollen samples monthly during the whole flowering season in 2019 and 2020. We searched for almost 400 compounds, including fungicides, herbicides, insecticides, and acaricides. We then calculated for each pollen sample the Pollen Hazard Quotient (PHQ), an index that provides a measure of multi-residue toxicity of contaminated pollen. Almost all pollen samples were contaminated by at least one compound. We detected 97 compounds, mainly fungicides, but insecticides and acaricides showed the highest toxicity. Fifteen % of the pollen samples had medium-high or high levels of PHQ, which could pose serious threats to honey bees. Fungicides showed a nearly constant PHQ throughout the season, while herbicides and insecticides and acaricides showed higher PHQ values in spring and early summer. Also, PHQ increased with increasing cover of agricultural and urban areas from April to July, while it was low and independent of landscape composition at the end of the season. The cover of perennial crops, i.e., fruit trees and vineyards, but not of annual crops, increased PHQ of pollen samples. Our work highlighted that the potential toxicity of pollen collected by honey bees was modulated by complex interactions among pesticide category, seasonality, and landscape composition. Due to the large number of compounds detected, our study should be complemented with additional experimental research on the potential interactive effects of multiple compounds on honey bee health., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Lorenzo Marini reports financial support was provided by Horizon Europe. Valeria Malagnini, Paolo Fontana, and Gino Angeli report financial support was provided by Associazione Produttori Ortofrutticoli Trentini., (Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Background: Pesticide exposure might increase risk of lung cancer. The purpose of this study was to investigate the association between the historical use of pesticides and lung cancer using a case-control design., Methods: This case-control study compared a lifetime pesticide exposure of 233 lung cancer cases, and 447 healthy neighbours matched for gender, and age (±5 years). Data on demographic, pesticide exposure and other related factors were collected using a face-to-face interview questionnaire. Associations between lung cancer and types of pesticides as well as individual pesticides were analysed using logistic regression adjusted for gender, age, cigarette smoking, occupation, cooking fumes exposure, and exposure to air pollution., Results: It was found that lung cancer was positively associated with the lifetime use of herbicides and insecticides. Compared to people in the non-exposed groups, those in Q3-Q4 days of using herbicides and insecticides had an elevated risk of lung cancer, with odds ratio (OR) between 2.20 (95% confidence interval (CI) 1.24-3.89), and 3.99 (95% CI 1.62-7.11) (p < 0.001). For individual pesticides, those presenting a significant association with lung cancer were dieldrin (OR = 2.56; 95% CI 1.36-4.81), chlorpyrifos (OR = 3.29; 95 % CI 1.93-5.61), and carbofuran (OR = 2.10; 95% CI 1.28-3.42). It was also found, for the first time, carbofuran, glyphosate, and paraquat to be significantly associated with lung cancer., Conclusions: The study confirmed dieldrin, and chlorpyrifos as risk factors and suggested carbofuran, glyphosate, and paraquat as potential risk factors for the disease. The paper stands as a noteworthy contribution to literature, particularly because the majority of publications on the topic originate from developed Western countries. However, further studies are imperative to validate the results and pinpoint additional individual pesticides that may be associated with lung cancer., Competing Interests: No competing interests were disclosed., (Copyright: © 2024 Kangkhetkron T and Juntarawijit C.)

Pesticides are necessary for the control of pest plant, fungi and insect species. After application, they may find their way into waste streams, such as municipal sewage, where their spatio-temporal distribution has not been well characterised. To further understand the spatio-temporal distribution and to evaluate potential sources and fate after treatment, 64 pesticides were analysed in matched influents and effluents of 22 wastewater treatment plants (WWTPs) from across Australia. The pesticides consisted of 30 herbicides and 8 herbicide metabolites or transformation products, 16 insecticides and 10 fungicides. The samples were 1084 24-hr composite samples pooled into 113 samples. Pools represented two influent and one effluent pools at each of 22 sites in 2019, as well as two pools per year from 2009 to 2021 for an 11-year long-term temporal trend at a subset of two locations. The total population served by the 22 sites was equivalent to ~41 % of the Australian population. Of the 64 pesticides, 25 were detected in influent, with highest influent concentrations up to 100 μg/L and effluent concentrations up to 16 μg/L for the herbicide 2,4-D. The total mass of pesticides was extrapolated to Australia, suggesting ~33 t of the targeted pesticides entered WWTP influent annually nation-wide, with 14 t emitted into effluents annually. Long-term trends varied by analyte and for carbendazim decreases over time, may be related to restrictions in use. Risk quotients (RQs) were calculated for 14 analytes in the effluent. 35 % had an RQ above one, indicating a potential environmental risk. Fipronil had the highest RQ (49) at Site 6. The population-normalized mass loads of pesticides were site-specific, and in some cases correlated with land use attributes suggestive of point sources. This reflects a need to better characterise sources to enable prevention, or possible pre-treatment of pesticide-containing wastewater entering municipal sewage streams., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Ben Tscharke reports financial support was provided by Australian Criminal Intelligence Commission. Jochen Mueller reports financial support was provided by Australian Research Council. Emma Knight, Ben Tscharke and Jochen Mueller reports financial support was provided by the Australian Government Department of Agriculture, Fisheries and Forestry., (Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)

While the use of pesticides has improved grain productivity and controlled vector-borne diseases, the widespread use of pesticides has resulted in ubiquitous environmental residues that pose health risks to humans. A number of studies have linked pesticide exposure to diabetes and glucose dyshomeostasis. This article reviews the occurrence of pesticides in the environment and human exposure, the associations between pesticide exposures and diabetes based on epidemiological investigations, as well as the diabetogenic effects of pesticides based on the data from in vivo and in vitro studies. The potential mechanisms by which pesticides disrupt glucose homeostasis include induction of lipotoxicity, oxidative stress, inflammation, acetylcholine accumulation, and gut microbiota dysbiosis. The gaps between laboratory toxicology research and epidemiological studies lead to an urgent research need on the diabetogenic effects of herbicides and current-use insecticides, low-dose pesticide exposure research, the diabetogenic effects of pesticides in children, and assessment of toxicity and risks of combined exposure to multiple pesticides with other chemicals., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Jing Liu reports financial support was provided by National Key Research & Development Program of China, Ministry of Science and Technology. Jing Liu reports financial support was provided by National Natural Science Foundation of China. Jing Liu reports financial support was provided by Zhejiang Provincial Natural Science Foundation, China., (Copyright © 2023 Elsevier Ltd. All rights reserved.)

Contamination of the environment by pesticide residues is a growing concern given their widespread presence in the environment and their effects on ecosystems. Only a few studies have addressed the occurrence of pesticides in soils, and their results highlighted the need for further research on the persistence and risks induced by those substances. We monitored 111 pesticide residues (48 fungicides, 36 herbicides, 25 insecticides and/or acaricides, and two safeners) in 47 soils sampled across France under various land uses (arable lands, vineyards, orchards, forests, grasslands, and brownfields). Pesticides were found in 98% of the sites (46 of the 47 sampled), including untreated areas such as organic fields, forests, grasslands, and brownfields, with up to 33 different substances detected in one sample, mostly fungicides and herbicides. The concentrations of herbicides were the highest in soils with glyphosate, and its transformation product, AMPA, contributed 70% of the cumulative herbicides. Risk assessment underlined a moderate to high risk for earthworms in arable soils mostly attributed to insecticides and/or acaricides. Finally, the comparison with pesticide application by farmers underlines the presence of some residues long after their supposed 90% degradation and at concentrations higher than predicted environmental concentrations, leading to questions their real persistence in soils.

The Ave basin (North Atlantic Ocean Ecoregion) is highly disturbed by anthropogenic activities. The amounts and distribution patterns of 56 priority pesticides (fungicides, herbicides, and insecticides) dissolved in the aqueous phase (DAP) and suspended particle matter (SPM) were evaluated seasonally along the river, estuary and coastline. Over 83 % of the GC-MS/MS-identified pesticides were quantified in DAP and 91 % in SPM. Pesticides' average annual amounts were ≅316 ng/L and 1.3 μg/g (fungicides), ≅272 ng/L and 2.2 μg/g (herbicides) and ≅1344 ng/L and 6.6 μg/g (insecticides). Invertebrates were the most vulnerable trophic level in the theoretical assessment of pesticide mixture hazards. This hypothesis was strengthened by acute in vivo assays using Artemia salina and Daphnia magna. These data, and the fact that 38 % of pesticides showed concentrations above the maximum established by the European legislation, plus the high concentrations of nitrates, nitrites, ammonia and phosphates, request further depollution actions in this region., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier Ltd. All rights reserved.)

Accurate application of agrochemicals is an important way to achieve efficient use of chemicals and to combine limited pollution with effective control of weeds, pests, and diseases. In this context, we investigate the potential application of a new delivery system based on ink-jet technology. First, we describe the structure and functionality of ink-jet technology for agrochemical delivery. We then evaluate the compatibility of ink-jet technology with a range of pesticides (four herbicides, eight fungicides, and eight insecticides) and beneficial microbes, including fungi and bacteria. Finally, we investigated the feasibility of using ink-jet technology in a microgreens production system. The ink-jet technology was compatible with herbicides, fungicides, insecticides, and beneficial microbes that remained functional after passing through the system. In addition, ink-jet technology demonstrated higher area performance compared to standard nozzles under laboratory conditions. Finally, the application of ink-jet technology to microgreens, which are characterized by small plants, was successful and opened the possibility of full automation of the pesticide application system. The ink-jet system proved to be compatible with the main classes of agrochemicals and showed significant potential for application in protected cropping systems.

The water concentrations of 12 heavy and other metals/metalloids were analyzed seasonally along two horizontal-flow constructed wetlands (CWs) (Tancat Mília-TM and Tancat l'Illa-TLI) located within the Mediterranean Albufera de València Natural Park during 2020-2021. A wide-scope screening of pesticides present in waters was also performed. The two CWs were created to improve water quality and increase biodiversity. They currently receive effluent waters from two different tertiary-treatment wastewater plants, and the water flows along the CWs before being discharged into the main lagoon and a smaller lagoon in TM and TLI, respectively. TLI manages to reduce (Mn) or maintain the concentration of most of the studied elements (Zn, Ni, Hg, Cr, Fe Cd, Cu) at the same level as outside (67%). Only Al, Pb, B, and As remain at a higher concentration. TM also reduces Zn and Cu and keeps the concentration of Cr, Cd, and Hg (representing 42%). Al, Pb, B, and As remain at higher concentrations, as in TLI, but Ni, Fe, and Mn are also at higher concentrations. Although both CWs vary in their ability to remove elements, no risks to human health or the environment have been detected due to the low metal concentration in their outlets, all of them (except Hg) below the legal limits for environmental quality in the European Union. With the detection of 71 compounds in water in each CW area (26 herbicides, 26 insecticides, and 19 fungicides in TLI, and 29 herbicides, 23 insecticides, and 19 fungicides in TM), we also provide evidence of the impact of pesticides, which depends on the application method (helicopter, tractor), originated from areas with high agricultural pressure (chiefly rice crops) on systems (mainly TM) created to preserve biodiversity. Nevertheless, both systems provide crucial environmental services in water quality in this agrolandscape., (© 2022. The Author(s).)

Natural products (NPs) have long been an important source of, and inspiration for, developing novel compounds to control weeds, pathogens and insect pests. In this review, we use a dataset of 800 historic, current and emerging crop protection compounds to explore the influence of NPs on the introduction of new crop protection compounds (fungicides, herbicides, insecticides) as a function of time. NPs, their semisynthetic derivatives (NPDs) and compounds inspired by NPs (NP mimics, NPMs) account for 17% of all crop protection compounds. NPs, NPDs, and NPMs have been a fairly constant source of new agrochemicals over the past 70 years. NP synthetic equivalents (NPSEs) is a fourth group of NP-related crop protection compounds composed of synthetic compounds which by chance also happen to have an NP model (but are not involved in the discovery). If NPSE compounds are also included, then 50% of all crop protection compounds hypothetically could have had a NP origin. Similar trends also hold true for the impact of NPs on the discovery of new modes of action (MoA) or innovation in crop protection compounds as measured by the number of first-in-class compounds. NPs have had the largest impact on the numbers and global sales (2018 USD) of insecticides compared to fungicides and herbicides. The present analysis highlights NPs as a long-standing and continuing source of new chemistry, new MoAs and innovation in crop protection compound discovery. © 2021 Society of Chemical Industry., (© 2021 Society of Chemical Industry.)

Honey is a popular agricultural product containing mostly sugars and water, but due to its nutritious components and natural production by honeybees ( Apis mellifera ) from floral nectar, it is marketed as a premium health food item. As environmental monitors, honeybees can potentially transfer environmental contaminants to honey. Whilst pesticides can have ubiquitous presence in agricultural and urban areas, polycyclic aromatic hydrocarbons (PAHs) can be more prevalent in higher density urban/industrial environments. Australian beehives are customarily located in rural areas/forests, but it is increasingly popular to keep hives in urban areas. This study assessed the levels of environmental contaminants in honeys (n = 212) from Queensland/Australian sources including rural, peri-urban and urban areas. Honey samples were analysed by LC-MS/MS and GC-MS/MS for 53 herbicides, 83 pesticides, 18 breakdown products (for certain pesticides/herbicides) and 33 PAHs and showed low/negligible pesticide, herbicide and PAHs contamination, consistent regardless of honey origins.

In the present-day scenario, it is necessary to establish more flexible, effective and selective analytical methods that are easy to operate and less expensive. Cyclic voltammetry (CV) can be a useful technique to assess minute quantity of pollutants and in this work, an effort has been made to detect the trace quantification from the environmental samples. Herein, electrochemical sensor was fabricated using tungsten oxide nanorod (WO 3 ·0.33H 2 O) for sensitive detection of fungicide, carbendazim (CBZ). Under optimal conditions, while studying the effect of pH on peak current, the highest peak current was observed at pH 4.2. The degradation of CBZ followed the mixed diffusion-adsorption controlled and quasi-reversible processess at the WO 3 ·0.33H 2 O/GC electrode surface. Using WO 3 ·0.33H 2 O/GCE sensor in SWV provided the lowest limit of detection (LOD) and limit of quantification (LOQ) values of 2.21 × 10 -8  M and 7.37 × 10 -8  M, respectively over the concentration ranges of 1.0 × 10 -7  M to 2.5 × 10 -4  M. The proposed method demonstrates potential applicability of the fabricated sensor for soil and water samples analysis in the management of creating a benign environment., (Copyright © 2020 Elsevier Ltd. All rights reserved.)

An analytical method involving modified QuEChERS (quick, easy, cheap, effective, rugged and safe) technique coupled with LC-MS/MS (liquid chromatography-tandem mass spectroscopy) has been developed for simultaneous identification and quantification of 71 pesticides (insecticides/acaricides/nematicides (32), fungicides (12), herbicides (26), plant growth regulator (1)) in different pulses (edible seeds of leguminous plants), namely gram, lentil, black gram and pea. The analysis was done using Shimadzu LC-MS/MS-8030 instrument equipped with Zorbax Eclipse Plus C-18 column operating under electrospray ionization (ESI) in positive and negative modes. Validation of method was done as per a single laboratory validation approach. Nine-point linear calibration curves for each pesticide were obtained in the range of 0.005 to 2 μg/g with correlation coefficient of ≥ 0.98. Limit of detection (LOD) for all the pesticides was achieved in the range of 0.001-0.015 μg/g, whereas the limit of quantification (LOQ) were found in the range of 0.01-0.05 μg/g. Recovery studies were conducted at 0.01- and 0.05-μg/g level of fortification using modified buffered QuEChERS method standardized for low moisture foods. It was observed that due to matrix interference, only around 75% of the pesticides were recovered in an acceptable range of 70-120% when compared against the solvent standard. With matrix-matched standards, 95% of the recovery results came within acceptable range with highly acceptable HorRat ratio (between 0.2 and 0.8) indicating satisfactory precision. The global and expanded uncertainties for estimation of each pesticide in above-mentioned pulse matrices were calculated to evaluate the suitability of the developed method for quantification of pesticides in pulse matrices.

Background: Pesticides exposures could be implicated in the excess of Central Nervous System (CNS) tumors observed in farmers, but evidence concerning individual pesticides remains limited. Carbamate derivative pesticides, including herbicides and fungicides (i.e. (thio/dithio)-carbamates), have shown evidence of carcinogenicity in experimental studies in animals. In the French AGRICAN cohort, we assessed the associations between potential exposures to carbamate herbicides and fungicides and the incidence of CNS tumors, overall and by histological subtype., Methods: AGRICAN enrolled 181,842 participants involved in agriculture. Incident CNS tumors were identified by linkage with cancer registries from enrollment (2005-2007) until 2013. Individual exposures were assessed by combining information on lifetime periods of pesticide use on crops and the French crop-exposure matrix PESTIMAT, for each of the 14 carbamate and thiocarbamate herbicides and the 16 carbamate and dithiocarbamate fungicides registered in France since 1950. Associations were estimated using proportional hazard models with age as the underlying timescale, adjusting for gender, educational level and smoking., Results: During an average follow-up of 6.9 years, 381 incident cases of CNS tumors occurred, including 164 gliomas and 134 meningiomas. Analyses showed increased risks of CNS tumors with overall exposure to carbamate fungicides (Hazard Ratio, HR = 1.88; 95% CI: 1.27-2.79) and, to a lesser extent, to carbamate herbicides (HR = 1.44; 95% CI: 0.94-2.22). Positive associations were observed with specific carbamates, including some fungicides (mancozeb, maneb, metiram) and herbicides (chlorpropham, propham, diallate) already suspected of being carcinogens in humans., Conclusions: Although some associations need to be corroborate in further studies and should be interpreted cautiously, these findings provide additional carcinogenicity evidence for several carbamate fungicides and herbicides., (Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.)

The extraradical mycelium (ERM) produced by arbuscular mycorrhizal fungi is fundamental for the maintenance of biological fertility in agricultural soils, representing an important inoculum source, together with spores and mycorrhizal root fragments. Its viability and structural traits, such as density, extent and interconnectedness, which are positively correlated with the growth and nutrition of host plants, may be affected by different agronomic practices, including the use of pesticides and by different mycorrhizospheric communities. This work, carried out using a whole-plant experimental model system, showed that structural traits of ERM, such as length and density, were strongly decreased by the herbicides dicamba and glufosinolate and the fungicides benomyl and fenhexamid, while anastomosis frequency and hyphal branching were differentially modulated by singly inoculated mycorrhizospheric bacteria, depending on their identity.

Introduction: Despite widespread use, many herbicides and fungicides are not well studied for neurological effects. Fetal and infant brains are rapidly developing, yet the effects of early-life exposure to these classes of pesticides on visual and auditory function are unknown. Here we examined the effects of prenatal herbicide and fungicide exposure on infant grating visual acuity (VA) and auditory brainstem response (ABR)., Methods: 9 herbicides and 13 fungicides were measured in umbilical cord blood plasma from a cohort of infants in Fuyang County, China (n = 232). Grating VA and ABR latencies for waves I, III, V were measured at 3 time points: 6 weeks, 9 months, and 18 months. Outcomes included VA score, ABR wave V latency and ABR central conduction time (CCT [wave V- wave I]). Pesticides were analyzed as 3-level ordinal (non-detect [ND]/medium/high), or dichotomous (ND/detect), depending on detection rates. Linear mixed models were used to evaluate relations between pesticides and VA and ABR outcomes., Results: 2,4-dichloroacetic acid (2,4-D), prometryn, simazine, and tetrahydrophthalamide (THPI, a metabolite of captan) were detected in 27%, 81%, 17%, and 16% of samples, respectively. Infants prenatally exposed to 2,4-D had slower auditory response times at 6 weeks. Infants with cord levels of 2,4-D > 1.17 ng/mL had wave V latencies that were 0.12 (95% CI: 0.03, 0.22) ms slower (p = 0.01) and overall CCTs that were 0.15 (95% CI:0.05, 0.25) ms slower (p = 0.003) than infants with non-detectable 2,4-D in their cord blood. No other statistically significant findings were observed for the other herbicides and fungicides or for the grating VA outcome., Conclusions: Prenatal exposure to the herbicide 2,4-D was associated with slower auditory signal transmission in early infancy. ABR latencies reflect auditory pathway maturation and longer latencies may indicate delayed auditory development., (Copyright © 2019 Elsevier Inc. All rights reserved.)

Drug-likeness has long been studied in the pursuit of finding new medicines. Similarly, in the agrochemical field there is value in exploring the properties of the chemicals involved. Patterns that emerge can potentially influence future discovery campaigns to improve the probability of commercial success. In this study we investigate the acid/base properties and physicochemical characteristics of three classes of compounds: fungicides, herbicides and insecticides. In comparison with FDA-approved drugs, it was noted that the pesticides were generally smaller, possessed a neutral charge state and were more lipophilic. The results are discussed in the light of their intended targets.

Background: The in vitro fungicidal effects of six commonly used fungicides, namely fluazinam, propineb, copper(II) hydroxide, metiram, chlorothalonil and mancozeb, and herbicides, namely isoxaflutole, fluazifop-P-butyl, flurochloridone, foramsulfuron, pendimethalin and prosulfocarb, on mycelial growth, sporulation and conidial germination of entomopathogenic fungus Beauveria bassiana (ATCC 74040) were investigated. Mycelial growth rates and sporulation at 15 and 25 °C were evaluated on PDA plates containing 100, 75, 50, 25, 12.5, 6.25 and 0% of the recommended application rate of each pesticide. The tested pesticides were classified in four scoring categories based on reduction in mycelial growth and sporulation., Results: All pesticides, herbicides and fungicides tested had fungistatic effects of varying intensity, depending on their rate in the medium, on B. bassiana. The most inhibitory herbicides were flurochloridone and prosulfocarb, and fluazinam and copper(II) hydroxide were most inhibitory among the fungicides, while the least inhibitory were isoxaflutole and chlorothalonil. Sporulation and conidial germination of B. bassiana were significantly inhibited by all tested pesticides compared with the control treatment. Flurochloridone, foramsulfuron, prosulfocarb and copper(II) hydroxide inhibited sporulation entirely at 100% rate (99-100% inhibition), and the lowest inhibition was shown by fluazifop-P-butyl (22%) and metiram (33%). At 100% dosage, all herbicides in the test showed a high inhibitory effect on conidial germination. Conidial germination inhibition ranged from 82% with isoxaflutole to 100% with fluorochloridone, pendimethalin and prosulfocarb. At 200% dosage, inhibition rates even increased (96-100%)., Conclusions: All 12 pesticides tested had a fungistatic effect on B. bassiana of varying intensity, depending on the pesticide and its concentration. B. bassiana is highly affected by some herbicides and fungicides even at very low rates. Flurochloridone, foramsulfuron, prosulfocarb and copper(II) hydroxide stopped sporulation. Of all tested pesticides, isoxaflutole, fluazifop-P-butyl and chlorothalonil showed the least adverse effects and therefore probably could be compatible with B. bassiana in the field. © 2016 Society of Chemical Industry., (© 2016 Society of Chemical Industry.)

Several naturally occurring amino acid derivatives display significant activities against weeds, fungi and insects: some of them have been even commercialized and are applied as crop protection agents. The 53 most important amino acid natural products with such efficacy are presented in this review together with their natural source, mode of action and biological activity. The diversity of the manifold bacterial, fungal and plantal sources of these compounds is impressive as well as their completely different structural scaffolds, ranging from cyclopeptides via unique non-proteinogenic amino acids to peptidyl nucleosides, the broad range of target enzymes from several different biochemical pathways, which they inhibit and also the plethora of different weeds, fungi and insects they are able to control.

In this review, the synthesis of 30 agrochemicals that received an international standardization organization (ISO) name during the last five years (January 2010 to December 2014) is described. The aim is to showcase the range and scope of chemistries used to discover or produce the latest active ingredients addressing the crop protection industry's needs., (Copyright © 2015 Elsevier Ltd. All rights reserved.)

Over the past decades, concern has been increasing over reported declines in aboveground biodiversity on farmland. In many regions, data on the toxicity of pesticides to honeybees (Apis mellifera), but not wider nontarget arthropod (NTA) data, are required for pesticide registration. In Europe, the effects of pesticides on NTAs and honeybees have been the subject of regulatory risk assessment for more than 30 years, resulting in a large database. Although insecticides may be expected to affect NTA populations, solely identifying insecticidal modes of action for further NTA testing would result in redundancy among low‐risk testing products and may also exclude other modes of action with potential effects in the field. This study assessed whether the honeybee acute risk assessment could provide any indication of the potential impact and recovery time of NTAs in cropped areas at the field scale and, if so, how it might be used in a tiered testing approach. The hazard quotients (HQs; foliar application rate/LR50) were derived for 151 active substances (32% insecticides, 28% fungicides, 38% herbicides, 2% plant growth regulators) for which toxicity data for established EU Tier 1 NTA indicator species (Typhlodromus pyri, Aphidius rhopalosiphi) and application rate data were available. These HQs were compared with published NTA HQ thresholds indicating the time to recovery of NTA populations and communities in field studies (>1 to >12 months). Using the same application rate data, honeybee acute risk quotient (RQ) and HQ were also determined and compared with NTA HQs and honeybee regulatory thresholds. These comparisons demonstrated that, where required, the current regulatory honeybee acute RQ of 0.4 or honeybee HQ of 50 can provide an efficient screening tier to target NTA testing at those products and uses with potential effects in the field where recovery may exceed 12 months. Integr Environ Assess Manag 2024;20:2326–2333. © 2024 SETAC Key Points: Comparison of the 151 nontarget arthropod (NTA) hazard quotients (HQs) with the honeybee acute risk quotients (RQs) and HQs revealed that the current honeybee thresholds (RQ 0.4 or HQ 50) can provide an efficient screening tier to target any NTA testing at those product and use rates with potential effects in the field where recovery may exceed 12 months.Such an approach is also applicable with mixture products and off‐crop, with the relevance of the NTA HQ thresholds potentially being more widely addressed by assessing whether taxa identified in EU field studies encompass the traits of taxa within a region or of a particular species of interest. [ABSTRACT FROM AUTHOR]

Background and Objective: The use of pesticides poses serious risks to the health of living organisms. Knowing the type and amount of pesticide use can provide a good information base for managing potential risks from pesticide consumption. This study was carried out with the main objective of determining the types and amounts of pesticides used on agricultural land in East Azarbaijan Province in 2021. Materials and Methods: Information about the pesticides have been gathered and analyzed by referring to the Agricultural Jihad Organization and other relevant authorities. Calculations related to the amount of pesticides used per unit area were made using the total area of agricultural lands in the province. Results: Considering the frequency, 403 kinds of pesticides are used in the following order: Herbicides > Insecticides > Fungicides > Acaricides > Others > Disinfectants. Consdidering total consumption of 2873730 kg pesticides, the order based on the amount is: Insecticides > Herbicide > Fungicides > Miscellaneous > Acaricides and Disinfectants based on the amount. The total ratio of pesticides used to pesticides distributed through the official (government) channel is 2.51. The minimum, maximum, and mean consumption values in counties are 0.4, 21.4, and 4.21 ± 5.33 kg/ha, respectively, and for province is 2.38 kg/ha. There is a correlation between the amount of pesticide applied and the number of farmers and traders. Conclusion: The consumption of pesticides in the province is higher than the world average. Appropriate management of pesticides is required from the viewpoints of environment and health protection. [ABSTRACT FROM AUTHOR]

To ensure ongoing sustainability, the modern agrochemical industry is faced with enormous challenges. These arise from provision of high‐quality food to increasing water use and environmental impact as well as a growing world population. The loss of previous agrochemicals due to consumer perception, changing grower needs and ever‐changing regulatory requirements is higher than the number of active ingredients that are being introduced into the crop protection market. Therefore, the development of novel agrochemicals is essential to provide improved efficacy and environmental profiles. In this context, the introduction of fluorine atoms and fluorine‐containing motifs into a molecule is an important method to influence its physicochemical properties. These include, for example, small difluoro‐ and trifluoromethyl, or trifluoromethoxy groups at aryl or heterocyclic aryl moieties but also fragments like 2,2,2‐trifluoroethoxycarbonyl, trifluoromethylsulfonyl, trifluoroacetyl, as well as the so far unusal rest like heptafluoro‐iso‐propyl. This review gives an overview of recent developments of fluorine‐containing pesticides launched over the past 7 years and describes a selection of current fluorine‐containing development candidates. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry. [ABSTRACT FROM AUTHOR]

The identification and detection of pesticides is crucial to protecting both the environment and human health. However, it can be challenging to conveniently and rapidly differentiate between different types of pesticides. We developed a supramolecular fluorescent sensor array, in which calixarenes with broad-spectrum encapsulation capacity served as recognition receptors. The sensor array exhibits distinct fluorescence change patterns for seven tested pesticides, encompassing herbicides, insecticides, and fungicides. With a reaction time of just three minutes, the sensor array proves to be a rapid and efficient tool for the discrimination of pesticides. Furthermore, this supramolecular sensing approach can be easily extended to enable real-time and on-site visual detection of varying concentrations of imazalil using a smartphone with a color scanning application. This work not only provides a simple and effective method for pesticide identification and quantification, but also offers a versatile and advantageous platform for the recognition of other analytes in relevant fields. [ABSTRACT FROM AUTHOR]

Plain Language Summary: Diseases and weeds can reduce yield of peanut (Arachis hypogaea L.) if effective control measures including fungicides and herbicides are not used. A survey of 76 farmers in North Carolina and Virginia at Cooperative Extension Service meetings was completed relative to fungicide and herbicide use in 2021. Eighty‐two percent of farmers made between three and five herbicide applications, while 68% of farmers made between four and five fungicide applications. 2,4‐DB was the herbicide applied most frequently. The fungicide chlorothalonil was applied the most often. Pydiflumetofen was applied by 61% of farmers. Results from this survey can be used to inform regulatory agencies on pesticide use patterns by defining the relative importance of individual or groups of pesticides currently used to suppress pests and prevent or mitigate associated economic losses. [ABSTRACT FROM AUTHOR]

This paper assesses the impact of viticulture on water resource quality in the Mendoza wine region using the grey water footprint (GWF) approach to estimate the amount of water required to dilute pesticides commonly used in local vineyards. Our analysis indicates that to progress towards sustainable water management in viticulture, limiting or replacing pesticides with high GWF values is essential. We provide detailed results for 24 fungicides, 7 insecticides, and 7 herbicides, assessed at both microregion and district levels, offering insights into pesticide impacts across both detailed and broader spatial scales. At the microregion level, the herbicide Fluroxypyr-meptyl was found to have the highest GWF (1.10 m³ kg-1), followed by the fungicide Fosetyl-aluminium (0.59 m³ kg-1) and the insecticide Imidacloprid (0.41 m³ kg-1). Our findings also show that pesticide impacts vary at the district level, highlighting the need for localised management strategies. Additionally, the significant variability in GWFs at the local level underscores the necessity for region-specific water quality standards to more accurately assess and manage the environmental impact of pesticide use. This study provides a framework for similar assessments in other viticultural regions, aiding in the development of more informed pesticide management to enhance water resource sustainability.

Background: Few studies of the relationship between residential proximity to agricultural pesticide applications and pesticide levels in the home have incorporated crop location or wind direction. We evaluated the relationship between agricultural pesticide applications using the California Pesticide Use Reporting (CPUR) database and pesticide concentrations in carpet dust accounting for land use and wind direction. Methods: We measured concentrations (ng/g) of seven herbicides and two fungicides in carpet dust samples from 578 California homes (2001–2007). We created three metrics by computing the density (kg/km2) of use of each pesticide reported in CPUR within 0.5-, 1-, 2-, and 4-km buffers around homes 180- and 365-days before sampling (CPUR metric). We apportioned applications to the crop area within the buffers (CROP-A metric) and weighted CPUR applications by the proportion of days that the home was within ±45° of the downwind direction (W-CPUR metric). We modeled natural-log concentrations (Tobit regression) and dust detections (logistic regression) adjusting for season/year, occupation, and home/garden use. Results: Detections were >90 % for glyphosate, 2,4-D, and simazine. Detection rates and dust concentrations increased with increasing CPUR densities for all herbicides and one fungicide. Compared to homes without applications within 4 km, the highest tertile of 365-day glyphosate use was associated with ∼100 % higher concentrations (CPURT3>9.2kg/km2 %change = 110, 95 %CI = 55, 183; CROP-AT3>13.4kg/km2 %change = 144, 95 %CI = 81, 229; and W-CPURT3>2.1kg/km2 %change = 102, 95 %CI = 50, 171). The highest density tertiles of 2,4-D, simazine, and trifluralin were associated with 2- to 6-times higher concentrations, respectively; that was similar across metrics. Across all metrics, agricultural use of dacthal, dicamba, and iprodione were associated with 5- to 10-times higher odds of dust detections. Associations were unclear for 2-methyl-4-chlorophenoxyacetic acid and null for chlorothalonil. Conclusions: Agricultural herbicide and fungicide use was an important determinant of indoor contamination within 4 km of homes. Accounting for crops and wind direction did not substantially change these relationships.

BackgroundPrevious epidemiological studies have reported associations of pesticide exposure with poor cognitive function and behavioral problems. However, these findings have relied primarily on neuropsychological assessments. Questions remain about the neurobiological effects of pesticide exposure, specifically where in the brain pesticides exert their effects and whether compensatory mechanisms in the brain may have masked pesticide-related associations in studies that relied purely on neuropsychological measures.MethodsWe conducted a functional neuroimaging study in 48 farmworkers from Zarcero County, Costa Rica, in 2016. We measured concentrations of 13 insecticide, fungicide, or herbicide metabolites or parent compounds in urine samples collected during two study visits (approximately 3-5 weeks apart). We assessed cortical brain activation in the prefrontal cortex during tasks of working memory, attention, and cognitive flexibility using functional near-infrared spectroscopy (fNIRS). We estimated associations of pesticide exposure with cortical brain activation using multivariable linear regression models adjusted for age and education level.ResultsWe found that higher concentrations of insecticide metabolites were associated with reduced activation in the prefrontal cortex during a working memory task. For example, 3,5,6-trichloro-2-pyridinol (TCPy; a metabolite of the organophosphate chlorpyrifos) was associated with reduced activation in the left dorsolateral prefrontal cortex (β = -2.3; 95% CI: -3.9, -0.7 per two-fold increase in TCPy). Similarly, 3-phenoxybenzoic acid (3-PBA; a metabolite of pyrethroid insecticides) was associated with bilateral reduced activation in the dorsolateral prefrontal cortices (β = -3.1; 95% CI: -5.0, -1.2 and -2.3; 95% CI: -4.5, -0.2 per two-fold increase in 3-PBA for left and right cortices, respectively). These associations were similar, though weaker, for the attention and cognitive flexibility tasks. We observed null associations of fungicide and herbicide biomarker concentrations with cortical brain activation during the three tasks that were administered.ConclusionOur findings suggest that organophosphate and pyrethroid insecticides may impact cortical brain activation in the prefrontal cortex - neural dynamics that could potentially underlie previously reported associations with cognitive and behavioral function. Furthermore, our study demonstrates the feasibility and utility of fNIRS in epidemiological field studies.

Tomato production plays a crucial role in the livelihoods of farmers and agricultural households in the forest savanna transitional belt of Ghana. However, the success of tomato cultivation is hindered by the presence of insect pests and diseases, necessitating the use of agricultural inputs. This study aimed to identify the pesticides used in tomato farming, assess their World Health Organization (WHO) active ingredient hazard class, determine the precautionary behaviour associated with pesticide use by tomato farmers, and elucidate the socio-economic factors influencing pesticide usage in the Bono and Ahafo regions of Ghana. A multistage sampling procedure was employed to select 1009 respondents, who were administered a structured questionnaire. Descriptive statistics and logistic regression models were used to analyse the collected data. The results revealed that tomato farmers utilized 15 types of insecticides (e.g., lambda and chlorpyrifos ethyl based), 8 types of fungicides (e.g., mancozeb and sulphur + copper based), and 6 types of weedicides (mostly glyphosate based) on their crops. Notably, four insecticides and two fungicides types were found to be unregistered products. Lambda-cyhalothrin-based insecticides and mancozeb-based fungicides were predominantly used by the farmers. The assessed pesticides exhibited varying levels of hazard, ranging from slight to moderate. The study found that farmer training was a significant driver influencing insecticide use, while the educational level of farmers and average yield played important roles in determining fungicide use. Socio-economic factors such as being the head of the household, employing farm workers, the cultivated tomato variety, and farmer training influenced weedicide use. The type of tomato variety cultivated emerged as the primary socio-economic driver of pesticide use. The study recommended the establishment and implementation of a systematic monitoring regime for pesticide product marketing and use, with the aim of reducing the utilization of unregistered products by farmers. Implementing these measures supports sustainable tomato farming in the Bono and Ahafo regions of Ghana. [ABSTRACT FROM AUTHOR]

Faba beans are one of the most suitable grain legume crop for colder, maritime climates. However, there is limited information on the effect of changing from conventional to organic production methods and potential impacts of global warming on the health and performance of faba bean crops in Northern Europe. We therefore assessed the performance of faba beans grown with contrasting crop protection (with and without pesticides) and fertilization (with and without P and K fertilizer input) regimes used in organic and conventional production in seven growing seasons. Conventional crop protection and fertilization regimes had no effect on foliar disease severity, but resulted in small, but significant increases in faba bean yields. The overall yield gap between organic and conventional production regimes was relatively small (~10%), but there was substantial variation in yields between growing seasons/years. Redundancy analysis (RDA) showed that climate explanatory variables/drivers explained the largest proportion of the variation in crop performance and identified strong positive associations between (i) temperature and both straw and grain yield and (ii) precipitation and foliar disease severity. However, RDA also identified crop protection and variety as significant explanatory variables for faba bean performance. The relatively small effect of using P and K fertilizers on yields and the lack of a measurable effect of fungicide applications on foliar disease severity indicate that the use of these inputs in conventional faba beans may not be economical. Results also suggest that the yield gap between organic and conventional faba bean production is significant, but smaller than for other field crops. [ABSTRACT FROM AUTHOR]

This document is a review of the synthesis and properties of several new agrochemicals that have been developed for crop protection. The review highlights the diverse range of reactions used to discover and produce these agrochemicals, and emphasizes the importance of cost-effective production methods. The authors, who are experts in the field, hope that the information presented in the review will inspire new ideas and research in the area of life sciences. [Extracted from the article]

Studies to assess the effectiveness of an integrated effect of agrotechnological techniques (fertilizers, pesticides, tillage, and predecessors) and agrometeorological conditions on the harvest of spring wheat have been carried out in 2011–2023. The work was performed on leached low-power low-humus medium-loamy chernozem in Altai krai. The scheme of the stationary field experiment established in 2000 assumed the study of the following variants: (factor A) tillage: deep tillage (25–27 cm), surface tillage (14–16 cm), subsurface tillage, and the variant without tillage; (factor B) fertilizers: without fertilizers, presowing fertilizer (ammophos), basic fertilizer (ammonium nitrate) + presowing fertilizer; and (factor C) pesticides: without pesticides, dicoticides, dicoticides + graminicides, and dicoticides + graminicides + insecticides + fungicides. Wheat predecessors were created in the fallow (no-tillage–rapeseed)–wheat–oats–wheat–peas–wheat rotation and with permanent cultivation of wheat. The wheat yield (t/ha) after predecessors without fertilizers and pesticides averaged 1.53 for fallow, 1.27 for peas, 1.06 for oats, and 0.81 for permanent sowing. The dependence (r) of yield on May–June moisture conditions for these predecessors increased from 0.628 to 0.705, 0.870, and 0.918, respectively. The contribution of soil tillage (%) to the wheat yield variation decreased from fallow and peas (26.9–58.0%) to oats and permanent sowing (1.3–2.5%) and that of fertilizers and pesticides increased from 10.0 to 53.2% and from 29.7 to 51.5%, respectively. The yield increase (t/ha) after fertilization with ammophos at sowing decreased from fallow (0.15 t/ha) to peas (0.11 t/ha), oats (0.10 t/ha), and permanent sowing (0.08 t/ha), while the use of basic fertilization with ammonium nitrate led to its increase from 0.19 and 0.18 to 0.31 and 0.22 t/ha. Under good moisture conditions, the effectiveness of fertilizers increased by 1.5–2.0 times with increase in saturation with pesticides. [ABSTRACT FROM AUTHOR]

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This study delved into the impact of open biomass burning on the distribution of pesticide and polycyclic aromatic hydrocarbon (PAH) residues across soil, rice straw, total suspended particulates (TSP), particulate matter with aerodynamic diameter ≤ 10 µm (PM10), and aerosols. A combination of herbicides atrazine (ATZ) and diuron (DIU), fungicide carbendazim (CBD), and insecticide chlorpyriphos (CPF) was applied to biomass before burning. Post-burning, the primary soil pesticide shifted from propyzamide (67.6%) to chlorpyriphos (94.8%). Raw straw biomass retained residues from all pesticide groups, with chlorpyriphos notably dominating (79.7%). Ash residue analysis unveiled significant alterations, with elevated concentrations of chlorpyriphos and terbuthylazine, alongside the emergence of atrazine-desethyl and triadimenol. Pre-burning TSP analysis identified 15 pesticides, with linuron as the primary compound (51.8%). Post-burning, all 21 pesticides were detected, showing significant increases in metobromuron, atrazine-desethyl, and cyanazine concentrations. PM10 composition mirrored TSP but exhibited additional compounds and heightened concentrations, particularly for atrazine, linuron, and cyanazine. Aerosol analysis post-burning indicated a substantial 39.2-fold increase in atrazine concentration, accompanied by the presence of sebuthylazine, formothion, and propyzamide. Carcinogenic PAHs exhibited noteworthy post-burning increases, contributing around 90.1 and 86.9% of all detected PAHs in TSP and PM10, respectively. These insights advance understanding of pesticide dynamics in burning processes, crucial for implementing sustainable agricultural practices and safeguarding environmental and human health. [ABSTRACT FROM AUTHOR]

Biologically active compounds of natural or synthetic origin have a complex structure and generally contain various structural groups among which polycyclic cage amines are found. Hexaazaisowurtzitanes are representatives of these amines and studies on their biological activity began less than two decades ago, starting with research on the environmental impact of CL-20. This research helped to evaluate the risks of potential pollution in the habitat environments of living organisms and determine whether the chemical compounds in question could be utilized in pesticides, herbicides, fungicides, or medicinal drugs. The nomenclature of hexaazaisowurtzitane compounds has recently been expanded significantly, and some of them have demonstrated promise in the design of medicinal drugs. This paper review studies the pharmacological activity of the acyl derivatives of hexaazaisowurtzitane. Most of the compounds have been found to possess a high analgesic activity, providing a solution to the pressing issue of pain management in current pharmacology. Analgesic drugs currently used in the clinical practice do not meet all of the efficacy and safety requirements (gastro-, nephro-, hepato-, haematotoxicity, etc.). The material presented in the seven sections of this paper highlights information about hexaazaisowurtzitane derivatives. Furthermore, they have been observed to exhibit anti-inflammatory, anticonvulsant, antihypoxic, and antimetastatic activities, which render them highly promising for evaluation in various fields of medicinal practice. [ABSTRACT FROM AUTHOR]

Recently, the search for sustainable and environmentally friendly agrochemicals from natural origin is steadily growing. Propolis, a resinous substance collected by honeybees, well known for its diverse biological activities, has attracted the attention of scientists and farmers with its agrochemical potential in the last years. This review article aims to delve into the fascinating world of propolis and its utilization in agriculture. Here, we provide a brief overview of propolis: its chemical composition and the bioactive substances responsible for its biological properties. The effectiveness of propolis in controlling common pests and diseases that affect crops, suppressing postharvest illnesses of fruits and vegetables, stimulating plant defenses and increasing stress resistance, is reviewed. Discussion of the challenges and future perspectives related to the integration of propolis in agriculture is also one of our objectives, including chemical variability, standardization and regulatory considerations. We also focused on the latest research trends and technological advances that promise to unlock the full potential of propolis as a sustainable agricultural tool. [ABSTRACT FROM AUTHOR]

In the present study, results are presented regarding the negative effects of different concentrations of three classes of pesticides - an insecticide, herbicide and fungicide on one relatively uncommon, but reliable histochemical biomarker in the field of fish toxicology - lipid accumulation in the liver of common carp under laboratory conditions. [ABSTRACT FROM AUTHOR]

Recently, the search for sustainable and environmentally friendly agrochemicals from natural origin is steadily growing. Propolis, a resinous substance collected by honeybees, well known for its diverse biological activities, has attracted the attention of scientists and farmers with its agrochemical potential in the last years. This review article aims to delve into the fascinating world of propolis and its utilization in agriculture. Here, we provide a brief overview of propolis: its chemical composition and the bioactive substances responsible for its biological properties. The effectiveness of propolis in controlling common pests and diseases that affect crops, suppressing postharvest illnesses of fruits and vegetables, stimulating plant defenses and increasing stress resistance, is reviewed. Discussion of the challenges and future perspectives related to the integration of propolis in agriculture is also one of our objectives, including chemical variability, standardization and regulatory considerations. We also focused on the latest research trends and technological advances that promise to unlock the full potential of propolis as a sustainable agricultural tool.

Abstract Background Knowledge surrounding the association between exposure to pesticides and hypothyroidism is inconsistent and controversial. Methods The aim of present study was, therefore, to review scientific evidence systematically and conduct a meta-analysis into the contribution of exposure to pesticides to hypothyroidism. PubMed, Scopus, Web of Science, and Google Scholar were searched. The findings are presented as OR, HR, PR, IRR, and 95% confidence interval (95%CI). A fixed-effect model using the inverse-variance method and random-effects inverse-variance model with DerSimonian-Laird method were used for estimating the pooled estimates. Cochran Q and I2 tests were used to confirm the heterogeneity of selected studies. Results Twelve studies were included in the systematic review, and 9 studies in the meta-analysis. Epidemiological evidence suggested that exposure to insecticides including organochlorines, organophosphates, and pyrethroids increased risk of hypothyroidism (adjusted odds ratio (aOR) = 1.23, 95%CI = 1.14, 1.33 for organochlorines, aOR = 1.12, 95%CI = 1.07, 1.17 for organophosphates, aOR = 1.15, 95%CI = 1.03, 1.28 for pyrethroids). Exposure to herbicides also increased risk of hypothyroidism (aOR = 1.06, 95%CI = 1.02, 1.10). However, exposure to fungicides and fumigants was not found to be associated with hypothyroidism. Conclusion To increase current knowledge and confirm evidence to date future research needs to center on large-scale longitudinal epidemiological and biological studies, examination of dose–response relationships, the controlling of relevant confounding variables, using standardized and high sensitivity tools, and investigating the effects of environmental exposure.

Background Pesticide exposure might increase risk of lung cancer. The purpose of this study was to investigate the association between the historical use of pesticides and lung cancer using a case-control design. Methods This case-control study compared a lifetime pesticide exposure of 233 lung cancer cases, and 447 healthy neighbours matched for gender, and age (±5 years). Data on demographic, pesticide exposure and other related factors were collected using a face-to-face interview questionnaire. Associations between lung cancer and types of pesticides as well as individual pesticides were analysed using logistic regression adjusted for gender, age, cigarette smoking, occupation, cooking fumes exposure, and exposure to air pollution. Results It was found that lung cancer was positively associated with the lifetime use of herbicides and insecticides. Compared to people in the non-exposed groups, those in Q3-Q4 days of using herbicides and insecticides had an elevated risk of lung cancer, with odds ratio (OR) between 2.20 (95% confidence interval (CI) 1.24-3.89), and 3.99 (95% CI 1.62-7.11) (p < 0.001). For individual pesticides, those presenting a significant association with lung cancer were dieldrin (OR = 2.56; 95% CI 1.36-4.81), chlorpyrifos (OR = 3.29; 95 % CI 1.93-5.61), and carbofuran (OR = 2.10; 95% CI 1.28-3.42). It was also found, for the first time, carbofuran, glyphosate, and paraquat to be significantly associated with lung cancer. Conclusions The study confirmed dieldrin, and chlorpyrifos as risk factors and suggested carbofuran, glyphosate, and paraquat as potential risk factors for the disease. The paper stands as a noteworthy contribution to literature, particularly because the majority of publications on the topic originate from developed Western countries. However, further studies are imperative to validate the results and pinpoint additional individual pesticides that may be associated with lung cancer.