Author: "Wu, Qiaoyin" / Topic: hepatitis c virus - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Wu, Qiaoyin"' showing total 5 results

Start Over Author "Wu, Qiaoyin" Topic hepatitis c virus

Author: Michael O'neil Hanrahan Clarke, Jie Xu, Edward Doerffler, Todd Appleby, X. Christopher Sheng, Choung U. Kim, Thomas Butler, John O. Link, William E. Delaney, Mingzhe Ji, Xiaowu Chen, Ruby Cai, Cottell Jeromy J, Hyung-Jung Pyun, Wu Qiaoyin, Aesop Cho, and Rowchanak Pakdaman
Subjects: Models, Molecular, Serine Proteinase Inhibitors, Hepatitis C virus, Hepacivirus, Clinical Biochemistry, Carboxylic Acids, Biological Availability, Pharmaceutical Science, Viral Nonstructural Proteins, Crystallography, X-Ray, medicine.disease_cause, Antiviral Agents, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Pharmacokinetics, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Molecular Biology, biology, Chemistry, Organic Chemistry, Quinoline, virus diseases, Hepatitis C, biology.organism_classification, medicine.disease, Virology, digestive system diseases, Rats, Macaca fascicularis, Caco-2, Quinolines, Molecular Medicine, Caco-2 Cells
Abstract: The discovery of GS-9451 is reported. Modification of the P3 cap and P2 quinoline with a series of solubilizing groups led to the identification of potent HCV NS3 protease inhibitors with greatly improved pharmacokinetic properties in rats, dogs and monkeys.
Published: 2012

Author: Anthony Casarez, Aesop Cho, William E. Delaney, Choung U. Kim, Mingzhe Ji, Xiaowu Chen, Jie Xu, Edward Doerffler, Rowchanak Pakdaman, Hyung-Jung Pyun, Wu Qiaoyin, Michael O'neil Hanrahan Clarke, Mertzman Michael E, Ruby Cai, Tanisha D. Rowe, and X. Christopher Sheng
Subjects: Swine, Hepatitis C virus, medicine.medical_treatment, Clinical Biochemistry, Cell, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, medicine.disease_cause, Biochemistry, Peptides, Cyclic, chemistry.chemical_compound, Inhibitory Concentration 50, Dogs, Pharmacokinetics, Genotype, Drug Discovery, medicine, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Protease, Molecular Structure, Chemistry, Organic Chemistry, Quinoline, Intracellular Signaling Peptides and Proteins, virus diseases, Virology, Phosphinic Acids, medicine.anatomical_structure, Molecular Medicine, Carrier Proteins, Ns3 4a protease
Abstract: A potent and novel class of phosphinic acid derived product-like inhibitors of the HCV NS3/4A protease was discovered previously. Modification of the phosphinic acid and quinoline heterocycle led to GS-9256 with potent cell-based activity and favorable pharmacokinetic parameters. Based on these attributes, GS-9256 was advanced to human clinical trial as a treatment for chronic infection with genotype 1 HCV.
Published: 2011

Author: Phillips, Barton, Cai, Ruby, Delaney, William, Du, Zhimin, Ji, Mingzhe, Jin, Haolun, Lee, Johnny, Li, Jiayao, Niedziela-Majka, Anita, Mish, Michael, Pyun, Hyung-Jung, Saugier, Joe, Tirunagari, Neeraj, Wang, Jianhong, Yang, Huiling, Wu, Qiaoyin, Sheng, Chris, and Zonte, Catalin
Subjects: *HEPATITIS C virus, *ENZYME inhibitors, *GENOTYPE-environment interaction, *VIRAL proteins, *TISSUE scaffolds
Abstract: The exploration of novel inhibitorsof the HCV NS4B protein thatare based on a 2-oxadiazoloquinoline scaffold is described.Optimization to incorporate activity across genotypes led to a potentnew series with broad activity, of which inhibitor 1displayedthe following EC50values: 1a, 0.08 nM; 1b, 0.10 nM; 2a, 3 nM; 2b, 0.6 nM, 3a, 3.7 nM; 4a, 0.9 nM; 6a, 3.1nM. [ABSTRACT FROM AUTHOR]
Published: 2014
Full Text: View/download PDF

Author: Christopher Sheng, X., Appleby, Todd, Butler, Thomas, Cai, Ruby, Chen, Xiaowu, Cho, Aesop, Clarke, Michael O., Cottell, Jeromy, Delaney, William E., Doerffler, Edward, Link, John, Ji, Mingzhe, Pakdaman, Rowchanak, Pyun, Hyung-Jung, Wu, Qiaoyin, Xu, Jie, and Kim, Choung U.
Subjects: *PHARMACEUTICAL research, *HEPATITIS C virus, *PROTEASE inhibitors, *QUINOLINE, *DRUG synergism, *PHARMACOKINETICS, *LABORATORY monkeys
Abstract: Abstract: The discovery of GS-9451 is reported. Modification of the P3 cap and P2 quinoline with a series of solubilizing groups led to the identification of potent HCV NS3 protease inhibitors with greatly improved pharmacokinetic properties in rats, dogs and monkeys. [Copyright &y& Elsevier]
Published: 2012
Full Text: View/download PDF

Author: Sheng, X. Christopher, Casarez, Anthony, Cai, Ruby, Clarke, Michael O., Chen, Xiaowu, Cho, Aesop, Delaney, William E., Doerffler, Edward, Ji, Mingzhe, Mertzman, Michael, Pakdaman, Rowchanak, Pyun, Hyung-Jung, Rowe, Tanisha, Wu, Qiaoyin, Xu, Jie, and Kim, Choung U.
Subjects: *VIRAL disease treatment, *PHARMACEUTICAL research, *PHOSPHINIC acid, *HEPATITIS C virus, *PROTEASE inhibitors, *DRUG synergism, *PHARMACOKINETICS
Abstract: Abstract: A potent and novel class of phosphinic acid derived product-like inhibitors of the HCV NS3/4A protease was discovered previously. Modification of the phosphinic acid and quinoline heterocycle led to GS-9256 with potent cell-based activity and favorable pharmacokinetic parameters. Based on these attributes, GS-9256 was advanced to human clinical trial as a treatment for chronic infection with genotype 1 HCV. [Copyright &y& Elsevier]
Published: 2012
Full Text: View/download PDF

Books, media, physical & digital resources

Searchworks