1. Strategies to manage hepatitis C virus (HCV) disease burden
- Author
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William Sievert, Wolfgang Vogel, C. E. Brandão Mello, Maria Lucia Gomes Ferraz, José Giria, Chris Estes, Homie Razavi, Martin Kåberg, Morris Sherman, Gamal Shiha, Christoph Sarrazin, Johannes Wiegand, J Parkes, Stephen D. Ryder, Filipe Calinas, Jan Sperl, Kevork M. Peltekian, Markus Cornberg, Matthew E. Cramp, Karolin Falconer, Marc Bilodeau, P. Van Damme, Anne Øvrehus, Philip Bruggmann, Maria Buti, Jose Luis Calleja, H. Van Vlierberghe, J. Félix, Achim Kautz, Jan Gerstoft, Peer Brehm Christensen, Gregory J. Dore, Necati Örmeci, Petr Urbánek, Kelly Kaita, N. Reis, Alexander J. Thompson, Javier García-Samaniego, Fernando L. Gonçales, Thomas Berg, S. Frankova, E. Gower, Amany Zekry, Peter Stärkel, Daniel Lavanchy, Florian Bihl, Beat Müllhaupt, Rui Tato Marinho, M. C. Mendes Correa, Pablo Lázaro, Françoise Roudot-Thoraval, Mette Rye Clausen, Vratislav Nemecek, Mel Krajden, Ulus Salih Akarca, İsmail Balik, Wim Laleman, Stuart K. Roberts, S. Mauss, Robert P. Myers, Michael Gschwantler, Wahid Doss, Sabahattin Kaymakoglu, Imam Waked, Hugo Cheinquer, Ayman Yosry, Gül Ergör, Ann-Sofi Duberg, Alnoor Ramji, Henrique Sérgio Moraes Coelho, H. Wedemeyer, Christophe Moreno, Christophe Hézode, Francesco Negro, S. J. Hindman, Henrik Krarup, Dominique Vandijck, I. van Thiel, Gamal Esmat, M Guimarães Pessôa, Manal H El-Sayed, Nina Weis, Paul Marotta, Antonio Javier Blasco, Ramazan Idilman, Rui Sarmento-Castro, Harald Hofer, Paulo R. Ferreira, David Semela, Rudolf E. Stauber, Petr Husa, Soo Aleman, William Rosenberg, Hannover Med Sch, German Liver Fdn, Orebro Univ Hosp, Univ Orebro, Hosp Valle de Hebron, UCL, Inst Clin & Expt Med, Cairo Univ, Ankara Univ, Ghent Univ Hosp, Wilhelminenspital Stadt Wien, Ege Univ, Karolinska Inst, Karolinska Univ Hosp, Univ Leipzig, Osped Cantonale, Univ Montreal, Adv Tech Hlth Serv Res TAISS, Fed Univ State Rio de Janeiro, Arud Ctr Addict Med, Hosp Santo Antonio Capuchos, Hosp Puerta Hierro, Univ Fed Rio Grande do Sul, Odense Univ Hosp, Region Hosp Hovedstaden, Universidade Federal do Rio de Janeiro (UFRJ), Univ Plymouth, Univ New S Wales, Ain Shams Univ, Dokuz Eylul Univ, Ctr Dis Anal CDA, Exigo Consultores, Universidade Federal de São Paulo (UNIFESP), Hosp Carlos III, Univ Copenhagen, Direccao Geral Saude, Universidade Estadual de Campinas (UNICAMP), Universidade de São Paulo (USP), Hop Henri Mondor, Med Univ Vienna, Masaryk Univ, Univ Manitoba, Hlth Sci Ctr, European Liver Patients Assoc, Istanbul Univ, Univ British Columbia, Aalborg Univ Hosp, Katholieke Univ Leuven, Univ Western Ontario, Univ Dusseldorf, Univ Libre Brussels, Univ Zurich Hosp, Univ Calgary, Natl Inst Publ Hlth, Univ Southhampton, Dalhousie Univ & Hepatol Serv, Assembleia Republ, Alfred Hosp, Monash Univ, Nottingham Univ Hosp NHS Trust, Biomed Res Unit, Ctr Hosp Porto, JW Goethe Univ Hosp, Cantonal Hosp St Gallen, Univ Toronto, Egyptian Liver Res Inst & Hosp ELRIAH, Catholic Univ Louvain, Med Univ Graz, St Vincents Hosp, Univ Melbourne, Charles Univ Prague, Cent Mil Hosp, Univ Antwerp, Deutsch Leberhilfe eV, Univ Ghent, Hasselt Univ, Med Univ Innsbruck, Natl Liver Inst, Copenhagen Univ Hosp, Univ Hosp, Monash Hlth, Bihl, Florian, Semela, David, and Negro, Francesco
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medicine.medical_specialty ,diagnosis ,Hepatitis C virus ,Population ,prevalence ,ddc:616.07 ,medicine.disease_cause ,law.invention ,Telaprevir ,disease burden ,03 medical and health sciences ,chemistry.chemical_compound ,Liver disease ,0302 clinical medicine ,Randomized controlled trial ,law ,Virology ,Internal medicine ,medicine ,030212 general & internal medicine ,education ,Disease burden ,ddc:616 ,education.field_of_study ,Hepatology ,treatment ,business.industry ,Ribavirin ,scenarios ,Hepatitis C ,medicine.disease ,mortality ,3. Good health ,Infectious Diseases ,chemistry ,HCV ,incidence ,030211 gastroenterology & hepatology ,epidemiology ,Human medicine ,hepatitis C ,business ,medicine.drug - Abstract
Gilead Sciences The number of hepatitis C virus (HCV) infections is projected to decline while those with advanced liver disease will increase. A modeling approach was used to forecast two treatment scenarios: (i) the impact of increased treatment efficacy while keeping the number of treated patients constant and (ii) increasing efficacy and treatment rate. This analysis suggests that successful diagnosis and treatment of a small proportion of patients can contribute significantly to the reduction of disease burden in the countries studied. the largest reduction in HCV-related morbidity and mortality occurs when increased treatment is combined with higher efficacy therapies, generally in combination with increased diagnosis. With a treatment rate of approximately 10%, this analysis suggests it is possible to achieve elimination of HCV (defined as a >90% decline in total infections by 2030). However, for most countries presented, this will require a 3-5 fold increase in diagnosis and/or treatment. Thus, building the public health and clinical provider capacity for improved diagnosis and treatment will be critical. Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, D-30625 Hannover, Germany German Liver Fdn, Hannover, Germany Orebro Univ Hosp, Dept Infect Dis, Orebro, Sweden Univ Orebro, Sch Hlth & Med Sci, SE-70182 Orebro, Sweden Hosp Valle de Hebron, CIBERehd, Barcelona, Spain UCL, Div Med, UCL Inst Liver & Digest Hlth, London, England Inst Clin & Expt Med, Dept Hepatogastroenterol, Prague, Czech Republic Cairo Univ, Cairo, Egypt Ankara Univ, TR-06100 Ankara, Turkey Ghent Univ Hosp, Ghent, Belgium Wilhelminenspital Stadt Wien, Dept Internal Med 4, Vienna, Austria Ege Univ, Izmir, Turkey Karolinska Inst, Dept Med Huddinge, Stockholm, Sweden Karolinska Univ Hosp, Dept Gastroenterol & Hepatol Infect Dis, Stockholm, Sweden Univ Leipzig, D-04109 Leipzig, Germany Osped Cantonale, Dept Gastroenterol, Bellinzona, Switzerland Univ Montreal, Dept Med, Liver Unit, Montreal, PQ H3C 3J7, Canada Adv Tech Hlth Serv Res TAISS, Madrid, Spain Fed Univ State Rio de Janeiro, Dept Gastroenterol, Rio de Janeiro, Brazil Arud Ctr Addict Med, Zurich, Switzerland Hosp Santo Antonio Capuchos, Ctr Hosp Lisboa Cent, Dept Gastroenterol, Lisbon, Portugal Hosp Puerta Hierro, Madrid, Spain Univ Fed Rio Grande do Sul, Hosp Clin, Porto Alegre, RS, Brazil Odense Univ Hosp, Dept Infect Dis, DK-5000 Odense, Denmark Region Hosp Hovedstaden, Region Hovedstaden, Denmark Univ Fed Rio de Janeiro, Dept Clin Med, Rio de Janeiro, Brazil Univ Plymouth, Peninsula Sch Med & Dent, Plymouth PL4 8AA, Devon, England Univ New S Wales, Kirby Inst, Sydney, NSW, Australia Ain Shams Univ, Cairo, Egypt Dokuz Eylul Univ, Izmir, Turkey Ctr Dis Anal CDA, Louisville, CO USA Karolinska Inst, Dept Med Huddinge, Karolinska Univ Hosp, Infect Dis Unit, Stockholm, Sweden Exigo Consultores, Alhos Vedros, Portugal Universidade Federal de São Paulo, Div Gastroenterol, São Paulo, Brazil Universidade Federal de São Paulo, Div Infect Dis, São Paulo, Brazil Hosp Carlos III, CIBERehd, Madrid, Spain Univ Copenhagen, Copenhagen, Denmark Direccao Geral Saude, Lisbon, Portugal Univ Estadual Campinas, Fac Ciencias Med, Disciplina Doencas Infecciosas, Grp Estudo Hepatites,Dept Clin Med, São Paulo, Brazil Univ São Paulo, Sch Med, Div Gastroenterol & Hepatol, São Paulo, Brazil Hop Henri Mondor, Serv Hepatogastroenterol, F-94010 Creteil, France Med Univ Vienna, Div Gastroenterol & Hepatol, Dept Internal Med 3, Vienna, Austria Masaryk Univ, Clin Infect Dis, Univ Hosp Brno, Brno, Czech Republic Ankara Univ, Dept Gastroenterol, Sch Med, TR-06100 Ankara, Turkey Univ Manitoba, Dept Internal Med, Sect Hepatol, Winnipeg, MB, Canada Hlth Sci Ctr, Viral Hepatitis Invest Unit, Winnipeg, MB, Canada European Liver Patients Assoc, St Truiden, Belgium Istanbul Univ, Istanbul, Turkey Univ British Columbia, British Columbia Ctr Dis Control, Vancouver, BC V5Z 1M9, Canada Aalborg Univ Hosp, Dept Med Gastroenterol, Aalborg, Denmark Aalborg Univ Hosp, Sect Mol Diagnost, Aalborg, Denmark Katholieke Univ Leuven, Univ Hosp Leuven, Louvain, Belgium Univ Western Ontario, Div Gastroenterol, London, ON, Canada Univ Dusseldorf, Dusseldorf, Germany Univ São Paulo, Sch Med, São Paulo, Brazil Univ Libre Brussels, Erasme Univ Hosp, Brussels, Belgium Univ Zurich Hosp, Swiss HPB Hepatopancreatobiliary Ctr, CH-8091 Zurich, Switzerland Univ Zurich Hosp, Dept Gastroenterol & Hepatol, CH-8091 Zurich, Switzerland Univ Calgary, Div Gastroenterol & Hepatol, Liver Unit, Calgary, AB, Canada Natl Inst Publ Hlth, Natl Reference Lab Hepatitis, Prague, Czech Republic Univ Southhampton, Southampton, England Dalhousie Univ & Hepatol Serv, Queen Elizabeth II Hlth Sci Ctr, Capital Dist Hlth Author, Dept Med, Halifax, NS, Canada Dalhousie Univ & Hepatol Serv, Queen Elizabeth II Hlth Sci Ctr, Capital Dist Hlth Author, Dept Surg, Halifax, NS, Canada Univ British Columbia, Dept Gastroenterol, Vancouver, BC V5Z 1M9, Canada Assembleia Republ, Lisbon, Portugal Alfred Hosp, Melbourne, Vic, Australia Monash Univ, Melbourne, Vic 3004, Australia Hop Henri Mondor, Dept Sante Publ, F-94010 Creteil, France Nottingham Univ Hosp NHS Trust, Nottingham, England Biomed Res Unit, Nottingham, England Ctr Hosp Porto, Dept Infect Dis, Oporto, Portugal JW Goethe Univ Hosp, Frankfurt, Germany Cantonal Hosp St Gallen, Div Gastroenterol & Hepatol, St Gallen, Switzerland Univ Toronto, Toronto Gen Hosp, Univ Hlth Network, Toronto, ON M5G 1L7, Canada Egyptian Liver Res Inst & Hosp ELRIAH, Dakahliah, Egypt Catholic Univ Louvain, Clin Univ St Luc, Brussels, Belgium Med Univ Graz, Div Gastroenterol & Hepatol, Dept Internal Med, Graz, Austria St Vincents Hosp, Dept Gastroenterol, Melbourne, Vic, Australia Univ Melbourne, Melbourne, Vic, Australia Charles Univ Prague, Dept Internal Med, Fac Med 1, Prague, Czech Republic Cent Mil Hosp, Prague, Czech Republic Univ Antwerp, B-2020 Antwerp, Belgium Deutsch Leberhilfe eV, Cologne, Germany Univ Ghent, Dept Hlth Econ & Patient Safety, B-9000 Ghent, Belgium Hasselt Univ, Diepenbeek, Belgium Med Univ Innsbruck, A-6020 Innsbruck, Austria Natl Liver Inst, Menoufia, Egypt Copenhagen Univ Hosp, Hvidovre, Denmark Univ New S Wales, St George Hosp Clin Sch Med, Sydney, NSW, Australia Univ New S Wales, Sch Med Sci, Sydney, NSW, Australia Univ Hosp, Div Gastroenterol & Hepatol, Geneva, Switzerland Univ Hosp, Div Clin Pathol, Geneva, Switzerland Monash Hlth, Melbourne, Vic, Australia Division of Gastroenterology, Federal University of São Paulo, São Paulo, Brazil Division of Infectious Disease, Federal University of São Paulo, São Paulo, Brazil Web of Science
- Published
- 2014
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