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2 results on '"Shang-Tao Lin"'

1. The Accuracy of Sonography in Predicting Steatosis and Fibrosis in Chronic Hepatitis C

Author

Chien-Hua Chen, Chien-Long Kuo, Yung-Hsiang Yeh, Shang-Tao Lin, Chiu-Kue Nien, and Chi-Chieh Yang

Subjects
Adult, Liver Cirrhosis, Male, medicine.medical_specialty, Physiology, Biopsy, Sensitivity and Specificity, Gastroenterology, Predictive Value of Tests, Fibrosis, Internal medicine, medicine, Humans, Aged, Retrospective Studies, Ultrasonography, Chi-Square Distribution, medicine.diagnostic_test, business.industry, Fatty liver, Hepatitis C, Hepatitis C, Chronic, Middle Aged, Hepatology, medicine.disease, Fatty Liver, Predictive value of tests, Liver biopsy, Female, Steatosis, business, Hepatic fibrosis
Abstract

The accuracy and clinical significance of sonography (US) in demonstrating fatty liver and hepatic fibrosis in chronic hepatitis C (CHC) are rarely reported. US had sensitivity 71.1%, specificity 72.9%, 58.7% positive predictive value (PPV), and 82.3% negative predictive value (NPV) in demonstrating histological steatosis > or =5%. US had sensitivity 85.7%, specificity 60.4%, 13% PPV, and 98.4% NPV in demonstrating histological steatosis > or =30% with clinical significance in predicting prognosis and therapeutic response in CHC. Subjects with fatty liver on US had a greater prevalence of body mass index (BMI) > or =25 kg/m2, inflammation-necrosis grade >2, and total bilirubin

Published
2007

2. The Accuracy of Sonography in Predicting Steatosis and Fibrosis in Chronic Hepatitis C.

Author

Shang-Tao Lin, Chi-Chieh Yang, Chien-Long Kuo, and Chiu-Kue Nien

Subjects
*ULTRASONIC imaging, *FATTY degeneration, *FIBROSIS, *HEPATITIS C
Abstract

Abstract  The accuracy and clinical significance of sonography (US) in demonstrating fatty liver and hepatic fibrosis in chronic hepatitis C (CHC) are rarely reported. US had sensitivity 71.1%, specificity 72.9%, 58.7% positive predictive value (PPV), and 82.3% negative predictive value (NPV) in demonstrating histological steatosis ≥5%. US had sensitivity 85.7%, specificity 60.4%, 13% PPV, and 98.4% NPV in demonstrating histological steatosis ≥30% with clinical significance in predicting prognosis and therapeutic response in CHC. Subjects with fatty liver on US had a greater prevalence of body mass index (BMI) ≥25 kg/m2, inflammation-necrosis grade >2, and total bilirubin r = −0.167, P = 0.083). Besides hepatic steatosis, clinicians should be alert to the possibility of advanced necrosis-inflammation grade in interpreting a report of bright liver on gray-scale US. Gray-scale US cannot replace liver biopsy as the optimal diagnostic procedure for the prediction of hepatic steatosis and fibrosis prior to initiating therapy for CHC. [ABSTRACT FROM AUTHOR]

Published
2008

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