1. Management of Clevudine-Resistant Chronic Hepatitis B: A Multicenter Cohort Study
- Author
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Eun Young Cho, Hyung Joon Yim, Young Kul Jung, Sang Jun Suh, Yeon Seok Seo, Ji Hoon Kim, Hong Soo Kim, Sae Hwan Lee, Sang Hoon Ahn, Jeong Il Lee, Sook-Hyang Jeong, Jin-Wook Kim, Jin-Woo Lee, In Hee Kim, Hyoung Su Kim, Sang Jong Park, Jeong Mi Lee, Seong Gyu Hwang, and Antiviral Resistance Study Group
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clevudine ,resistance ,hepatitis b ,chronic ,therapy ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Background/AimsData are lacking regarding the management of chronic hepatitis B (CHB) with resistance to clevudine (CLV). This study evaluated the efficacy of different rescue therapies for CLV-resistant CHB.Methods : Patients with CLV-resistant CHB were enrolled in the cohort, and all patients developed virologic breakthrough during CLV therapy and had confirmed-genotypic resistance to CLV (rtM204I mutation) before enrollment.Results : Of the 107 patients, 12 received adefovir (ADV), 21 received a CLV plus ADV combination (CLV+ADV), 34 received a lamivudine plus ADV combination (LAM+ADV), and 40 received entecavir (ETV) therapy for 48 weeks. The CLV+ADV group had the lowest hepatitis B virus (HBV) DNA level (p
- Published
- 2017
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