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In this article, the authors analyzed literature sources, describing the best tactics of transfusion therapy and domestic regulations. The results of randomized clinical trials of the last decade, testifying the advantages of restrictive tactics of transfusion therapy, have influenced a more rigorous record of indications for transfusions of blood components. The trend in the world of modern transfusiology is restrictive tactics of prescribing blood components - only by indication, only in a situation where the clinical prognosis worsens without transfusion. Blood saving technologies can effectively control and correct hemostasis, reduce the transfusion load and associated risks, and provide an increase in the amount of high-tech care. [ABSTRACT FROM AUTHOR]

The paper discusses the formation and functional characteristics of hemostasis in children, as well as the effect of brain tumors on the hemostatic potential of blood. Shifts in coagulation hemostasis in children are physiological and, as a rule, do not have a significant effect on the hemostatic potential of the blood, but they can easily transform into coagulopathy. Decompensation develops more easily, the lower the child’s age, this is due both to the peculiarities of the hemostasis system itself and to the immaturity of the central regulatory mechanisms. And used in the treatment process glucocorticoids tend to reduce the levels of procoagulant factors. The main cause of coagulopathy is the entry into the bloodstream of plasminogen activator factors from tumor cells or tissue factors from the damaged brain parenchyma during surgery. The use of thromboelastography in monitoring the coagulation of pediatric neurosurgical patients helps to identify patients with an increased risk of bleeding or thromboembolic complications and effectively treat them. [ABSTRACT FROM AUTHOR]