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The process of native blood coagulation was studied with the resonant-acoustic method using the technology of low-frequency piezothromboelastography. It is shown that the experimental curve of time dependence of the piezoelectric sensor signal amplitude reflects the change in the rheological properties of blood during coagulation. A formula is obtained that relates the change in the concentration of thrombin to the rate of change in the complex coefficient of blood viscosity. A method has been developed for assessing thrombin concentration during fibrinogenesis based on the technology of piezothromboelastography using a resonant-acoustic method for determining the viscoelastic properties of whole blood. The results of calculating the thrombin concentration by this method are compared with the results of the thrombin generation test. [ABSTRACT FROM AUTHOR]

A theoretical and experimental study of the viscoelastic properties of whole blood under oscillating shear stresses has been carried out. Based on ultrasonic elastography, a mathematical model and a method for calculating the complex viscosity coefficient of whole blood during its coagulation have been developed. The complex viscosity coefficient of whole blood and its real and imaginary parts were calculated. The calculated viscosity coefficient of blood at the beginning of the coagulation process is in good agreement with the data of rheometric measurements. The results obtained confirm the ability of using this approach to determine the viscoelastic properties of whole blood and analyze their dynamics during coagulation in a regime as close as possible to an in vivo study. [ABSTRACT FROM AUTHOR]