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Researchers from the Russian Academy of Sciences investigated the effects of indirubin, indole-3-carbinol, and B-naphthoflavone on the Aryl Hydrocarbon Receptor (AHR)/cytochrome 450 signaling pathway in various human cell lines. The study found that these compounds, known AHR ligands, have potential in treating cancer by affecting the expression of CYP1 genes and AHR protein levels in different cell lines. The research highlights the importance of considering the AHR/CYP1 signaling pathway in developing new strategies for cancer treatment. This study was supported by the Core Centrum of the Institute of Developmental Biology, RAS, and has been peer-reviewed. [Extracted from the article]

A study conducted at Xiangya Hospital in Changsha, China, explored the effects of compound probiotics on the pharmacokinetics of cytochrome P450 probe drugs in rats. The research found that the administration of VSL#3 probiotics altered the gut microbiota, gene expression related to drug metabolism, and intestinal structure in rats, leading to changes in drug bioavailability. This study provides a comprehensive understanding of how probiotics can impact drug metabolism and offers insights into potential reasons for pharmacokinetic changes. [Extracted from the article]