1. A Journey into the Clinical Relevance of Heme Oxygenase 1 for Human Inflammatory Disease and Viral Clearance: Why Does It Matter on the COVID-19 Scene?
- Author
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Ayelen Toro, María Sol Ruiz, Sofia Lage-Vickers, Pablo Sanchis, Agustina Sabater, Gaston Pascual, Rocio Seniuk, Florencia Cascardo, Sabrina Ledesma-Bazan, Felipe Vilicich, Elba Vazquez, and Geraldine Gueron
- Subjects
heme oxygenase 1 ,COVID-19 ,influenza A virus ,respiratory syncytial virus ,human immunodeficiency virus ,Ebola virus ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Heme oxygenase 1 (HO-1), the rate-limiting enzyme in heme degradation, is involved in the maintenance of cellular homeostasis, exerting a cytoprotective role by its antioxidative and anti-inflammatory functions. HO-1 and its end products, biliverdin, carbon monoxide and free iron (Fe2+), confer cytoprotection against inflammatory and oxidative injury. Additionally, HO-1 exerts antiviral properties against a diverse range of viral infections by interfering with replication or activating the interferon (IFN) pathway. Severe cases of coronavirus disease 2019 (COVID-19), an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are characterized by systemic hyperinflammation, which, in some cases, leads to severe or fatal symptoms as a consequence of respiratory failure, lung and heart damage, kidney failure, and nervous system complications. This review summarizes the current research on the protective role of HO-1 in inflammatory diseases and against a wide range of viral infections, positioning HO-1 as an attractive target to ameliorate clinical manifestations during COVID-19.
- Published
- 2022
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