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Start Over Author "Burshtein E" Topic hematopoiesis
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1. Reactions of granulocytic lineage of hemopoiesis and mechanisms of their development in combined treatment with adriablastin and taxotere.

Author

Gol'dberg VE, Khrichkova TY, Shatalova VA, Popova NO, Burshtein ES, Minakova MY, Zhdanov VV, and Dygai AM

Subjects
Antibiotics, Antineoplastic pharmacology, Antineoplastic Agents pharmacology, Antineoplastic Combined Chemotherapy Protocols, Bone Marrow Cells drug effects, Breast Neoplasms, Cell Proliferation drug effects, Docetaxel, Female, Humans, Neutrophils drug effects, Doxorubicin pharmacology, Granulocytes drug effects, Hematopoiesis drug effects, Taxoids pharmacology
Abstract

We studied myelotoxic effects of adriablastin and taxotere combination on granulocytic lineage cells and processes of their recovery in patients with stage III-IV breast cancer. Intensive maturation of granulocytic CFU provided regeneration of the hemopoiesis even under conditions of reduced proliferative activity of these cells, which, in turn, led to accumulation of mature and immature neutrophilic granulocytes in the bone marrow and improved reserve capacities of the neutrophil pool in the bone marrow.

Published
2011
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