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Your search keyword '"Di Concilio, Rosanna"' showing total 4 results
Start Over Author "Di Concilio, Rosanna" Topic hematology
4 results on '"Di Concilio, Rosanna"'

1. Nucleated red blood cells and soluble transferrin receptor in thalassemia syndromes: relationship with global and ineffective erythropoiesis.

Author

Danise, Paolo, Amendola, Giovanni, Di Concilio, Rosanna, Cillari, Enrico, Gioia, Maria, Di Palma, Anna, Avino, Daniela, Rigano, Paolo, and Maggio, Aurelio

Subjects
ERYTHROCYTES, HEMOGLOBINOPATHY, ERYTHROPOIESIS, THALASSEMIA, BLOOD transfusion, HEMATOLOGY
Abstract

Background: The technology to recognize nucleated red blood cells (NRBC) automatically has only recently been developed. Modern hematology analyzers allow for rapid and accurate NRBC counts. The goal of our study was to evaluate NRBC counts and the concentrations of serum transferrin receptor (sTfR) in patients affected by different thalassemia syndromes and hereditary spherocytosis. We wished to gain a better understanding of the meaning of the presence of NRBC in peripheral blood and the relationship of the two parameters with effective and ineffective erythropoiesis in the different thalassemia syndromes. Methods: NRBC counts in peripheral blood were evaluated in a large group of patients with thalassemia (36 thalassemia major, 55 thalassemia intermedia and 61 Sβ-thalassemia patients) and compared with data from 29 patients with hereditary spherocytosis; in all the patients the concentration of sTfR was evaluated as an index of global erythropoiesis. Results: The NRBC count showed a good relationship with ineffective erythropoiesis: highest counts were observed in the thalassemia syndromes characterized by almost completely ineffective erythropoiesis. NRBCs were absent in patients affected by hereditary spherocitosis, a disease characterized by effective erythropoiesis. Conclusions: The NRBC count can be useful for better defining ineffective erythropoiesis in patients with thalassemia, and can help optimize transfusion therapy in severe thalassemia syndromes. Clin Chem Lab Med 2009;47:1539–42. [ABSTRACT FROM AUTHOR]

Published
2009
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2. Risk factors for endocrine complications in transfusion-dependent thalassemia patients on chelation therapy with deferasirox: a risk assessment study from a multi-center nation-wide cohort

Author

Raffaella Origa, Antonella Sau, Maria Caterina Putti, Maurizio Poggi, Gian Luca Forni, Antonella Quarta, Alessandro Cattoni, Marilena Serra, Immacolata Tartaglione, Domenico Roberti, Elena Cassinerio, Elisa De Michele, Patrizia Sturiale, Filomena Sportelli, Saveria Campisi, Antonio Ivan Lazzarino, Massimo Allò, Silverio Perrotta, Rosanna Di Concilio, Daniela Pasquali, Alessia Marcon, Angelo Peluso, Stefania Picariello, Maddalena Casale, Francesca Ferrara, Roberta Renni, Saverio Ladogana, Lucia Dora Notarangelo, Casale, Maddalena, Luca Forni, Gian, Cassinerio, Elena, Pasquali, Daniela, Origa, Raffaella, Serra, Marilena, Campisi, Saveria, Peluso, Angelo, Renni, Roberta, Cattoni, Alessandro, De Michele, Elisa, Allò, Massimo, Poggi, Maurizio, Ferrara, Francesca, Di Concilio, Rosanna, Sportelli, Filomena, Quarta, Antonella, Caterina Putti, Maria, Dora Notarangelo, Lucia, Sau, Antonella, Ladogana, Saverio, Tartaglione, Immacolata, Picariello, Stefania, Marcon, Alessia, Sturiale, Patrizia, Roberti, Domenico, Ivan Lazzarino, Antonio, Perrotta, Silverio, Casale, M, Forni, G, Cassinerio, E, Pasquali, D, Origa, R, Serra, M, Campisi, S, Peluso, A, Renni, R, Cattoni, A, De Michele, E, Allò, M, Poggi, M, Ferrara, F, Di Concilio, R, Sportelli, F, Quarta, A, Putti, M, Notarangelo, L, Sau, A, Ladogana, S, Tartaglione, I, Picariello, S, Marcon, A, Sturiale, P, Roberti, D, Lazzarino, A, and Perrotta, S

Subjects
medicine.medical_specialty, Iron Overload, Thalassemia, blood transfusion, Iron Chelating Agents, Benzoates, Risk Assessment, 03 medical and health sciences, Liver disease, 0302 clinical medicine, Risk Factors, Internal medicine, Medicine, Endocrine system, Humans, Chelation therapy, iron chelation, business.industry, Incidence (epidemiology), Deferasirox, beta-Thalassemia, Hematology, Triazoles, medicine.disease, Chelation Therapy, 030220 oncology & carcinogenesis, Cohort, business, Complication, Thalassemia, endocrine complications, iron chelation, deferasirox, endocrine function, 030215 immunology, medicine.drug, Follow-Up Studies
Abstract

Transfusion-dependent patients typically develop iron-induced cardiomyopathy, liver disease, and endocrine complications. We aimed to estimate the incidence of endocrine disorders in transfusiondependent thalassemia (TDT) patients during long-term iron-chelation therapy with deferasirox (DFX). We developed a multi-center follow-up study of 426 TDT patients treated with once-daily DFX for a median duration of 8 years, up to 18.5 years. At baseline, 118, 121, and 187 patients had 0, 1, or ≥2 endocrine diseases respectively. 104 additional endocrine diseases were developed during the follow-up. The overall risk of developing a new endocrine complication within 5 years was 9.7% (95% Confidence Interval [CI]: 6.3–13.1). Multiple Cox regression analysis identified three key predictors: age showed a positive log-linear effect (adjusted hazard ratio [HR] for 50% increase 1.2, 95% CI: 1.1–1.3, P=0.005), the serum concentration of thyrotropin showed a positive linear effect (adjusted HR for 1 mIU/L increase 1.3, 95% CI: 1.1–1.4, P

Published
2020

3. White matter volume changes in adult beta‐thalassemia: Negligible and unrelated to anemia and cognitive performances

Author

Sara Ponticorvo, Mario Cirillo, Andrea G. Russo, Federica Ammendola, Renzo Manara, Rosanna Di Concilio, Silverio Perrotta, Andrea Elefante, Francesco Di Salle, Domenico Roberti, Angela Ciancio, Martina Caiazza, Pasquale Alessandro Carafa, Antonietta Canna, Maddalena Casale, Elisa De Michele, Immacolata Tartaglione, Fabrizio Esposito, Manara, Renzo, Canna, Antonietta, Caiazza, Martina, Ponticorvo, Sara, Russo, Andrea G, Di Concilio, Rosanna, Ciancio, Angela, De Michele, Elisa, Carafa, Pasquale Alessandro, Ammendola, Federica, Roberti, Domenico, Casale, Maddalena, Elefante, Andrea, Cirillo, Mario, Di Salle, Francesco, Esposito, Fabrizio, Perrotta, Silverio, Tartaglione, Immacolata, Manara, R., Canna, A., Caiazza, M., Ponticorvo, S., Russo, A. G., Di Concilio, R., Ciancio, A., De Michele, E., Carafa, P. A., Ammendola, F., Roberti, D., Casale, M., Elefante, A., Cirillo, M., Di Salle, F., Esposito, F., Perrotta, S., and Tartaglione, I.

Subjects
Adult, Anemia, business.industry, beta-Thalassemia, Physiology, Beta thalassemia, Cognition, Syndrome, Anemia, Sickle Cell, Hematology, medicine.disease, White Matter, White matter, medicine.anatomical_structure, Volume (thermodynamics), medicine, business, Human
Published
2020
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4. No evidence of increased cerebrovascular involvement in adult neurologically-asymptomatic β-Thalassaemia. A multicentre multimodal magnetic resonance study

Author

Gianluca Femina, Antonietta Canna, Sara Ponticorvo, Renzo Manara, Violetta Caserta, Maddalena Casale, Paolo Gritti, Elisa De Michele, Silverio Perrotta, Andrea G. Russo, Teresa Ferrantino, Camilla Russo, Martina Caiazza, Mario Cirillo, Giovanni Amendola, Antonella Centanni, Noemi Ippolito, Fabrizio Esposito, Angela Ciancio, Rosanna Di Concilio, Andrea Elefante, Ilaria Granato, Mario Ermani, Tiziana Oliveto, Pasquale Alessandro Carafa, Immacolata Tartaglione, Tartaglione, Immacolata, Russo, Camilla, Elefante, Andrea, Caiazza, Martina, Casale, Maddalena, Di Concilio, Rosanna, Ciancio, Angela, De Michele, Elisa, Amendola, Giovanni, Gritti, Paolo, Carafa, Pasquale A, Ferrantino, Teresa, Centanni, Antonella, Ippolito, Noemi, Caserta, Violetta, Oliveto, Tiziana, Granato, Ilaria, Femina, Gianluca, Esposito, Fabrizio, Ponticorvo, Sara, Russo, Andrea G, Canna, Antonietta, Ermani, Mario, Cirillo, Mario, Perrotta, Silverio, Manara, Renzo, Tartaglione, I., Russo, C., Elefante, A., Caiazza, M., Casale, M., Di Concilio, R., Ciancio, A., De Michele, E., Amendola, G., Gritti, P., Carafa, P. A., Ferrantino, T., Centanni, A., Ippolito, N., Caserta, V., Oliveto, T., Granato, I., Femina, G., Esposito, F., Ponticorvo, S., Russo, A. G., Canna, A., Ermani, M., Cirillo, M., Perrotta, S., and Manara, R.

Subjects
Adult, medicine.medical_specialty, brain MRI, Adolescent, transfusion medicine, Venography, thalassaemia, Asymptomatic, Magnetic resonance angiography, Brain Ischemia, White matter, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Leukoencephalopathies, medicine, Humans, thrombosi, Prospective Studies, vascular malformations, thrombosis, Aged, medicine.diagnostic_test, business.industry, beta-Thalassemia, Brain, Intracranial Aneurysm, Magnetic resonance imaging, Intracranial Artery, Hematology, Middle Aged, medicine.disease, Magnetic Resonance Imaging, White Matter, Thrombosis, Hyperintensity, medicine.anatomical_structure, Case-Control Studies, 030220 oncology & carcinogenesis, Radiology, Nervous System Diseases, medicine.symptom, business, Magnetic Resonance Angiography, 030215 immunology
Abstract

Multi-factorial causes jeopardize brain integrity in β-thalassaemia. Intracranial parenchymal and vascular changes have been reported among young β-thalassaemia patients but conventional magnetic resonance imaging (MRI) findings are contradictory making early MRI and magnetic resonance angiography (MRA)/venography monitoring a matter of debate. This study prospectively investigated 75 neurologically asymptomatic β-thalassaemia patients (mean-age 35·2±10·7years; 52/75 transfusion-dependent; 41/75 splenectomised) using a 3T magnetic resonance scanner; clinical, laboratory and treatment data were also collected. White matter ischaemic-like abnormalities, intracranial artery stenoses, aneurysms and sinus venous thrombosis were compared between patients and 56 healthy controls (mean-age 33·9±10·8years). No patient or control showed silent territorial or lacunar strokes, intracranial artery stenoses or signs of sinus thrombosis. White matter lesions were found both in patients (35/75, 46·7%) and controls (28/56, 50·0%), without differences in terms of number (4·0±10·6 vs. 4·6±9·1, P=0·63), size and Fazekas' Score. Intracranial aneurysms did not differ between patients and controls for incidence rate (7/75, 9·3% vs. 5/56, 8·9%), size and site. Vascular and parenchymal abnormality rate did not differ according to treatments or clinical phenotype. According to this study, asymptomatic β-thalassaemia patients treated according to current guidelines do not seem to carry an increased risk of brain and intracranial vascular changes, thus weakening recommendations for regular brain MRI monitoring.

Published
2019

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