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1. 16th International Conference on Dialysis. Advances in Chronic Kidney Disease 2014. January 22-25, 2014, Caesars Palace, Las Vegas, Nev.: Abstracts

Author

Jeroen P. Kooman, Giovanni Tripepi, Albert Power, Ralf Schindler, Margaret Nevin, Aileen Grassmann, Michael Etter, Adam Tashman, Ewa Żukowska-Szczechowska, Chi-Hung Cheng, Yuedong Wang, Mathias Schaller, Marianna Bellantoni, Giovannella Baggio, Claudia Barth, Annalisa Salari, Yosef S. Haviv, Flavio Basso, Neill Duncan, Marina Loucaidou, Judy Weintraub, Giancarlo Bombonato, Grazia Maria Virzì, Len A. Usvyat, Magdalena Mokrejsova, Adrian Guinsburg, Shang-Feng Tsai, Cristina Marelli, Ya-Wen Chuang, Stephan Thijssen, Olaf Boenisch, Alessandra Brendolan, Lina Minazzato, Simon Beagle, Claire Edwards, Michiel G. H. Betjes, Umberto Cillo, Piero Amodio, Druck Reinhardt Druck Basel, Franklin W. Maddux, Frank M. van der Sande, Peter Kotanko, Kuo-Hsiung Shu, Giacomo Zanus, Ted Toffelmire, Nicolle H.R. Litjens, Ruud W. J. Meijers, Mary Carter, Seema K Singh, Dinna N. Cruz, Anna Clementi, Sonya Day, Werner Beck, Tung-Min Yu, Eva Pazourkova, Reinhold Deppisch, Sami Schiff, Runolfur Palsson, Inga Bayh, Vladimir Tesar, Ying-Chih Lo, Daniele Neri, Richard Corbett, Anna Giuliani, Sampson Antwi, Olafur Skuli Indridason, Allen R. Nissenson, Claudia Torino, Carmine Zoccali, Alessandra Brocca, Shih-Ting Huang, Vincenzo Cantaluppi, Massimo de Cal, Ales Horinek, Daniele Marcelli, Sachin S Soni, Peter Choi, Satz Mengensatzproduktion, Laura Scatizzi, Pasquale Piccinni, Francesca Mallamaci, Antonio Granata, Marie Korabecna, Ming-Ju Wu, F. Klefisch, Olof Viktorsdottir, Damien Ashby, Daniel Zickler, Cheng-Hsu Chen, Giovanna Berdin, Giorgio Vescovo, Grzegorz Wystrychowski, Gero von Gersdorff, Claudio Ronco, Giacomo Mason, C. Kneis, Caroline Williams, Marzena Wjewodzka, Stephen McMurray, Tonino Bianco, Terry Ketchersid, Rocco Tripepi, Nathan W. Levin, John Callegari, and Charles D. Pusey

Subjects
Gerontology, medicine.medical_specialty, Las vegas, business.industry, General surgery, medicine.medical_treatment, Hematology, General Medicine, medicine.disease, Nephrology, medicine, business, Dialysis, Kidney disease
Published
2013
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2. Contents Vol. 36, 2013

Author

Jeroen P. Kooman, Daniel Zickler, Sachin S Soni, Olaf Boenisch, Yosef S. Haviv, Simon Beagle, Werner Beck, Michael Etter, Runolfur Palsson, Kuo-Hsiung Shu, Annalisa Salari, Dinna N. Cruz, Claudia Barth, Vincenzo Cantaluppi, Giovanni Tripepi, Laura Scatizzi, Marie Korabecna, Tonino Bianco, Giancarlo Bombonato, Grazia Maria Virzì, Len A. Usvyat, Charles D. Pusey, Satz Mengensatzproduktion, Ying-Chih Lo, Shang-Feng Tsai, Shih-Ting Huang, Neill Duncan, Caroline Williams, Stephan Thijssen, Damien Ashby, Cheng-Hsu Chen, Grzegorz Wystrychowski, Cristina Marelli, Chi-Hung Cheng, Giorgio Vescovo, Olafur S. Indridason, Flavio Basso, Giacomo Zanus, Yuedong Wang, Judy Weintraub, Eva Pazourkova, Ales Horinek, Marzena Wjewodzka, Nathan W. Levin, Adrian Guinsburg, Ewa Żukowska-Szczechowska, Magdalena Mokrejsova, Claudia Torino, Frank M. van der Sande, Marianna Bellantoni, Massimo de Cal, Nicolle H.R. Litjens, Vladimir Tesar, Peter Choi, Francesca Mallamaci, Claire Edwards, Mathias Schaller, Daniele Marcelli, Terry Ketchersid, Antonio Granata, Pasquale Piccinni, Marina Loucaidou, Claudio Ronco, Ming-Ju Wu, Lina Minazzato, F. Klefisch, Ya-Wen Chuang, Mary Carter, Giacomo Mason, Druck Reinhardt Druck Basel, Alessandra Brocca, Ralf Schindler, Margaret Nevin, Piero Amodio, Rocco Tripepi, Franklin W. Maddux, Inga Bayh, Ted Toffelmire, Sampson Antwi, Sonya Day, Giovanna Berdin, Ruud W. J. Meijers, Stephen McMurray, John Callegari, Sami Schiff, Gero von Gersdorff, Michiel G. H. Betjes, Allen R. Nissenson, Reinhold Deppisch, Olof Viktorsdottir, Alessandra Brendolan, Anna Clementi, C. Kneis, Umberto Cillo, Daniele Neri, Seema K Singh, Tung-Min Yu, Anna Giuliani, Carmine Zoccali, Peter Kotanko, Aileen Grassmann, Richard Corbett, Albert Power, Adam Tashman, and Giovannella Baggio

Subjects
Nephrology, Hematology, General Medicine
Published
2013
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3. Monitoring Dialysis Outcomes across the World - The MONDO Global Database Consortium

Author

Jeroen P. Kooman, Len A. Usvyat, Frank M. van der Sande, Yosef S. Haviv, Yuedong Wang, Adam Tashman, Ted Toffelmire, Mathias Schaller, Adrian Guinsburg, Nathan W. Levin, Cristina Marelli, Inga Bayh, Michael Etter, Albert Power, Gero von Gersdorff, Claudia Barth, Aileen Grassmann, Stephan Thijssen, Laura Scatizzi, Charles D. Pusey, Daniele Marcelli, Peter Kotanko, Interne Geneeskunde, and RS: NUTRIM - R3 - Chronic inflammatory disease and wasting

Subjects
Local practice, Databases, Factual, Descriptive statistics, Database, business.industry, Reproducibility of Results, Hematology, General Medicine, Patient data, Joint analysis, Global Health, Dialysis patients, computer.software_genre, Renal Dialysis, Nephrology, Outcome Assessment, Health Care, Global health, Humans, Medicine, Observational study, Registries, Dialysis (biochemistry), business, computer
Abstract

Background/Aims: Dialysis providers frequently collect detailed longitudinal and standardized patient data, providing valuable registries of routine care. However, even large organizations are restricted to certain regions, limiting their ability to separate effects of local practice from the pathophysiology shared by most dialysis patients. To overcome this limitation, the MONDO (MONitoring Dialysis Outcomes) research consortium has created a platform for the joint analysis of data from almost 200,000 dialysis patients worldwide. Methods: We examined design and operation of MONDO as well as its methodology with respect to patient inclusion, descriptive data and other study parameters. Results: MONDO partners contribute primary databases of anonymized patient data and collaboratively analyze populations across national and regional boundaries. To that end, datasets from different electronic health record systems are converted into a uniform structure. Patients are enrolled without systematic exclusions into open cohorts representing the diversity of patients. A large number of patient level treatment and outcome data is recorded frequently and can be analyzed with little delay. Detailed variable definitions are used to determine if a parameter can be studied in a subset or all databases. Conclusion: MONDO has created a large repository of validated dialysis data, expanding the opportunities for outcome studies in dialysis patients. The density of longitudinal information facilitates in particular trend analysis. Limitations include the paucity of uniform definitions and standards regarding descriptive information (e.g. comorbidities), which limits the identification of patient subsets. Through its global outreach, depth, breadth and size, MONDO advances the observational study of dialysis patients and care.

Published
2013
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4. Temporal evolution of clinical parameters before death in dialysis patients: a new concept

Author

Len A. Usvyat, Christoph Huber, Nathan W. Levin, Peter Kotanko, Anja Kruse, Stephan Thijssen, and Adam Tashman

Subjects
Male, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Serum albumin, Dialysis patients, Weight loss, Internal medicine, Weight Loss, medicine, Humans, Chronic hemodialysis, Serum Albumin, Cause of death, Aged, Retrospective Studies, Aged, 80 and over, biology, business.industry, Albumin, Retrospective cohort study, Hematology, General Medicine, Middle Aged, Prognosis, Surgery, Death, Nephrology, biology.protein, Kidney Failure, Chronic, Female, Hemodialysis, medicine.symptom, business, Biomarkers
Abstract

Background: Chronic hemodialysis (HD) patients experience an appallingly high mortality in the range of 20% per year. Little is known on the dynamics of key clinical and laboratory variables in the weeks and months preceding death. In order to gain more insight into events preceding death, we embarked on a novel methodological approach which encompasses data analysis from the date of death backwards in time. Methods: The current study investigates the dynamics of postdialytic weight and serum albumin levels in the 24 months preceding death. We performed a retrospective analysis of 2,462 maintenance HD patients who died between July 1, 2005 and April 30, 2008. Patients’ monthly serum albumin levels were extracted for the 24 months preceding the date of death. Similarly, the median weekly postdialysis weight was extracted for the 104 weeks prior to death. Data were analyzed with linear mixed models. Results: Both albumin levels and postdialytic body weight showed a significant decrease irrespective of gender and race in the 3 final months of life. The most pronounced decreases in postdialytic weight and albumin levels were observed in patients with infection as cause of death, the smallest changes occurred in subjects with cerebrovascular events. Conclusions: In their final 3 months of life, HD patients experience a marked decrease in body weight and serum albumin levels. A better understanding of dynamic patterns of key variables before death may be useful in developing processes which alert medical caregivers to patients at increased risk, in order to institute timely diagnostic and therapeutic interventions.

Published
2009

5. Acknowledgement to the Reviewers

Author

Inga Bayh, Sampson Antwi, Reinhold Deppisch, Alessandra Brocca, Daniele Neri, Judy Weintraub, Damien Ashby, Giovanna Berdin, Yosef S. Haviv, Runolfur Palsson, Cheng-Hsu Chen, Neill Duncan, Gero von Gersdorff, Aileen Grassmann, Cristina Marelli, Terry Ketchersid, Caroline Williams, Vladimir Tesar, Daniele Marcelli, Lina Minazzato, Nathan W. Levin, Claudia Barth, Ewa Żukowska-Szczechowska, Piero Amodio, Anna Giuliani, Satz Mengensatzproduktion, C. Kneis, Flavio Basso, Adrian Guinsburg, Marzena Wjewodzka, Frank M. van der Sande, Ying-Chih Lo, Shang-Feng Tsai, Anna Clementi, Nicolle H.R. Litjens, Shih-Ting Huang, Seema K Singh, John Callegari, Grzegorz Wystrychowski, Claire Edwards, Alessandra Brendolan, Stephan Thijssen, Ruud W. J. Meijers, Rocco Tripepi, Tung-Min Yu, Michael Etter, Umberto Cillo, Ales Horinek, Carmine Zoccali, Stephen McMurray, Simon Beagle, Tonino Bianco, Daniel Zickler, Richard Corbett, Claudia Torino, Massimo de Cal, Charles D. Pusey, Chi-Hung Cheng, Yuedong Wang, Olafur S. Indridason, Mathias Schaller, Werner Beck, Druck Reinhardt Druck Basel, Kuo-Hsiung Shu, Albert Power, Pasquale Piccinni, Mary Carter, Michiel G. H. Betjes, Olof Viktorsdottir, Peter Choi, Claudio Ronco, Giacomo Mason, Vincenzo Cantaluppi, Giovanni Tripepi, Francesca Mallamaci, Ya-Wen Chuang, Ming-Ju Wu, Laura Scatizzi, Eva Pazourkova, Peter Kotanko, F. Klefisch, Sonya Day, Magdalena Mokrejsova, Sami Schiff, Allen R. Nissenson, Marianna Bellantoni, Antonio Granata, Olaf Boenisch, Marina Loucaidou, Sachin S Soni, Dinna N. Cruz, Giorgio Vescovo, Giacomo Zanus, Annalisa Salari, Giancarlo Bombonato, Grazia Maria Virzì, Len A. Usvyat, Jeroen P. Kooman, Marie Korabecna, Ralf Schindler, Margaret Nevin, Franklin W. Maddux, Ted Toffelmire, Adam Tashman, and Giovannella Baggio

Subjects
Medical education, medicine.medical_specialty, Nephrology, business.industry, Acknowledgement, Immunology, Alternative medicine, medicine, Hematology, General Medicine, business
Published
2013
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