1. Moderate hypothermia suppressed excessive generation of superoxide anion radical and inflammatory reactions in blood and liver in heatstroke: Laboratory study in rats.
- Author
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Todani, Masaki, Fujita, Motoki, Tsuruta, Ryosuke, Nakahara, Takashi, Yagi, Takeshi, Oshima, Chiyomi, Igarashi, Masatsugu, Takahashi, Koshiro, Kasaoka, Shunji, Yuasa, Makoto, and Maekawa, Tsuyoshi
- Subjects
SUPEROXIDES ,HEAT stroke ,HYPOTHERMIA ,MALONDIALDEHYDE ,CELL adhesion molecules - Abstract
The study was performed to demonstrate superoxide radical (O
2 ·–) generation, systemic inflammation and liver injury caused by heatstroke and to reveal suppressive effects of moderate hypothermia. Heatstroke was defined as achieving pharyngeal temperature of 40°C with arterial pressure reduction. Heatstroke rats were divided to four groups by the temperature after the onset; 40°C, 37°C, 32°C and sham-treated with 37°C. O2 ·– current was measured continuously in the right atrium using an electrochemical O2 ·– senor. The O2 ·– current increased in all groups except for the sham-treated group during the induction. After the onset of heatstroke, the O2 ·– current was suppressed with temperature-dependency. Plasma and liver high-mobility group box 1, intercellular adhesion molecule-1, plasma aspartate aminotransferase and alanine aminotransferase were also suppressed with the suppression of O2 ·– generation. Therefore, excessive O2 ·– generation might be a key factor in heatstroke and the suppression with moderate hypothermia would be a therapeutic modality. [ABSTRACT FROM AUTHOR]- Published
- 2010
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