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Adversity early in life can modify the trajectory for disease risk extending decades beyond the event. Preterm birth produces persistent cardiovascular alterations that may appear maladaptive in adulthood. We have previously hypothesized that those born preterm may exhibit cardiovascular vulnerability in the climate change context. Further, this vulnerability may be present as early as childhood. We aimed to identify the early signs of cardiovascular dysfunction at childhood‐equivalent age using our animal model of preterm birth. Using a whole‐body thermal stress test, guinea pigs aged 35‐d and 38‐d (equivalent to 8–10‐year‐old children) and born at term or preterm gestations were exposed to progressive hyper‐ (TC = 41.5°C) and hypo‐thermia (TC = 34°C; normothermia TC = 39°C). Comprehensive cardiovascular monitoring included ECG, blood pressure, microvascular perfusion, blood gas, and catecholamine profile, as well as skin and core body temperature. Preterm‐born animals exhibited attenuated vascular responses to hyperthermic stress, and a significant elevation in systolic blood pressure in response to hypothermic stress. Such responses are similar to those observed in elderly populations and indicate the presence of cardiovascular dysfunction. This is the first study to demonstrate the impact of preterm birth on the cardiovascular response to both heat and cold stress. Further, this dysfunction has been observed at an earlier age than that achievable using traditional stress testing techniques. The present findings warrant further investigation. [ABSTRACT FROM AUTHOR]

Environmental justice is essential for improved quality of life and sustainable wellbeing. This study examines how environmental issues and related injustices are surfacing in U.S. social work practice and social work readiness to respond, and what resources social workers are most interested in. Data are from an online survey of U.S. social workers (N = 337) in Colorado, Ohio, and Tennessee. Participants answered questions about their social work background, current job, environmental issues in practice, resources, and demographics. Data were analyzed with descriptive statistics. For nine issues, at least 30% of participants reported these as surfacing sometimes or often, with the highest being poor food access (74.7%), extreme cold (58.8%), and poor green space access (43.9%). The extent varied by years of experience, job setting, and practice level. Meanwhile, fewer than 40% of social workers indicated that they were somewhat or very prepared to respond to eight out of nine issues. Interest was higher in the resources that could be used for responding to specific topics rather than environmental justice broadly. In addition to strengthening social work education regarding environmental justice, this study suggests that national, state, and local social work associations can—in partnership with growing numbers of social work scholars working on environmental justice—create and provide training, templates, and guidance for practitioners that are tailored to specific environmental justice issues. [ABSTRACT FROM AUTHOR]

The TATA-box binding protein (TBP) and TBP-associated factors (TAFs) constitute the transcription factor IID (TFIID), a crucial component of RNA polymerase II, essential for transcription initiation and regulation. Several TFIID subunits are shared with the Spt–Ada–Gcn5–acetyltransferase (SAGA) coactivator complex. Recent research has revealed the roles of TBP and TAFs in organogenesis and stress adaptation. In this study, we identified 1 TBP and 21 putative TAFs in the mungbean genome, among which VrTAF5, VrTAF6, VrTAF8, VrTAF9, VrTAF14, and VrTAF15 have paralogous genes. Their potential involvement in abiotic stress responses was also investigated here, including high salinity, water deficit, heat, and cold. The findings indicated that distinct genes exerted predominant influences in the response to different abiotic stresses through potentially unique mechanisms. Specifically, under salt stress, VrTBP, VrTAF2, and VrTAF15–1 were strongly induced, while VrTAF10, VrTAF11, and VrTAF13 acted as negative regulators. In the case of water-deficit stress, it was likely that VrTAF1, VrTAF2, VrTAF5–2, VrTAF9, and VrTAF15–1 were primarily involved. Additionally, in response to changes in ambient temperature, it was possible that genes such as VrTAF5–1, VrTAF6–1, VrTAF9–2, VrTAF10, VrTAF13, VrTAF14b–2, and VrTAF15–1 might play a dominant role. This comprehensive exploration of VrTBP and VrTAFs can offer a new perspective on understanding plant stress responses and provide valuable insights into breeding improvement. [ABSTRACT FROM AUTHOR]

Purpose of Review: Chronic inducible urticaria (CIndU) is a group of long-persisting and challenging to manage diseases, characterized by recurrent wheals and angioedema induced by definite triggers. In this review, we address recent findings on CIndU pathogenesis, diagnosis as well as its treatment, and we discuss novel potential targets that may lead to the development of more effective therapies for CIndU patients. Recent Advances: Meaningful advances in the understanding of its pathogenesis have been reported in the last decades. Novel CIndU-specific patient-reported outcome measures enable a closer and better evaluation of patients. Summary: CIndU is a hard-to-treat disease that highly impairs quality of life (QoL) of affected patients. Provocation tests allow to diagnose CIndU subtypes. The only licensed and recommended treatment for CIndU are second generation non-sedating H1-antihistamines, which lack efficacy in many cases. Omalizumab off-label use has been assessed in all types of CIndU with overall good outcomes. Promising emerging therapies currently assessed in chronic spontaneous urticaria are paving the path for novel treatments for CIndU [ABSTRACT FROM AUTHOR]

Effects of acute thermal exposures on appetite appear hypothetical in reason of very heterogeneous methodologies. The aim of this study was therefore to clearly define the effects of passive 24-h cold (16°C) and heat (32°C) exposures on appetitive responses compared with a thermoneutral condition (24°C). Twenty-three healthy, young and active male participants realised three sessions (from 13.00) in a laboratory conceived like an apartment dressed with the same outfit (Clo = 1). Three meals composed of three or four cold or warm dishes were served ad libitum to assess energy intake (EI). Leeds Food Preference Questionnaires were used before each meal to assess food reward. Subjective appetite was regularly assessed, and levels of appetitive hormones (acylated ghrelin, glucagon-like peptite-1, leptin and peptide YY) were assessed before and after the last meal (lunch). Contrary to the literature, total EI was not modified by cold or heat exposure (P = 0·120). Accordingly, hunger scores (P = 0·554) were not altered. Levels of acylated ghrelin and leptin were marginally higher during the 16 (P = 0·032) and 32°C (P < 0·023) sessions, respectively. Interestingly, implicit wanting for cold and low-fat foods at 32°C and for warm and high-fat foods at 16°C were increased during the whole exposure (P < 0·024). Moreover, cold entrées were more consumed at 32°C (P < 0·062) and warm main dishes more consumed at 16°C (P < 0·025). Thus, passive cold and hot exposures had limited effects on appetite, and it seems that offering some choice based on food temperature may help individuals to express their specific food preferences and maintain EI. [ABSTRACT FROM AUTHOR]

Musculoskeletal pain is a major burden in our society. Management of musculoskeletal pain or injuries includes both pharmacological and non-pharmacological approaches, including heat therapy (HT). HT is a well-established treatment option due to its ability to promote muscle relaxation, enhance blood circulation, and modulate nociceptors with a good safety profile. The main focus of this paper is to review the available literature about HT in knee pathologies (i.e., arthrosis, arthritis, traumatic pathologies in the subacute phase, muscle and tendon pathologies linked to fatigue, muscle tension and distractions) and to provide an expert opinion in case of lack of data. [ABSTRACT FROM AUTHOR]

Abnormal encoding of somatosensory modalities (ie, mechanical, cold, and heat) are a critical part of pathological pain states. Detailed phenotyping of patients' responses to these modalities have raised hopes that analgesic treatments could one day be tailored to a patient's phenotype. Such precise treatment would require a profound understanding of the underlying mechanisms of specific pain phenotypes at molecular, cellular, and circuitry levels. Although preclinical pain models have helped in that regard, the lack of a unified assay quantifying detailed mechanical, cold, and heat pain responses on the same scale precludes comparing how analgesic compounds act on different sensory phenotypes. The conflict avoidance assay is promising in that regard, but testing conditions require validation for its use with multiple modalities. In this study, we improve upon the conflict avoidance assay to provide a validated and detailed assessment of all 3 modalities within the same animal, in mice. We first optimized testing conditions to minimize the necessary amount of training and to reduce sex differences in performances. We then tested what range of stimuli produce dynamic stimulus-response relationships for different outcome measures in naive mice. We finally used this assay to show that nerve injury produces modality-specific sex differences in pain behavior. Our improved assay opens new avenues to study the basis of modality-specific abnormalities in pain behavior. [ABSTRACT FROM AUTHOR]

In the present study, we examined the effect of extreme temperatures on different life stages of Ephestia kuehniella Zeller (Lepidoptera: Pyralidae). The individuals were exposed to different temperatures ranging between 5 and −18 °C for cold treatment, and between 30 and 55 °C for heat treatment, and different exposure intervals, ranging from minutes to days. Complete control was achieved at −10 and −15 °C for cold treatment and 50 and 55 °C for heat treatment at all exposure intervals. Considering the efficacy of extreme temperatures for the control of E. kuehniella, our study provides specific temperature exposure modules that can be effective for the control of this species. [ABSTRACT FROM AUTHOR]

Abstract Adversity early in life can modify the trajectory for disease risk extending decades beyond the event. Preterm birth produces persistent cardiovascular alterations that may appear maladaptive in adulthood. We have previously hypothesized that those born preterm may exhibit cardiovascular vulnerability in the climate change context. Further, this vulnerability may be present as early as childhood. We aimed to identify the early signs of cardiovascular dysfunction at childhood‐equivalent age using our animal model of preterm birth. Using a whole‐body thermal stress test, guinea pigs aged 35‐d and 38‐d (equivalent to 8–10‐year‐old children) and born at term or preterm gestations were exposed to progressive hyper‐ (TC = 41.5°C) and hypo‐thermia (TC = 34°C; normothermia TC = 39°C). Comprehensive cardiovascular monitoring included ECG, blood pressure, microvascular perfusion, blood gas, and catecholamine profile, as well as skin and core body temperature. Preterm‐born animals exhibited attenuated vascular responses to hyperthermic stress, and a significant elevation in systolic blood pressure in response to hypothermic stress. Such responses are similar to those observed in elderly populations and indicate the presence of cardiovascular dysfunction. This is the first study to demonstrate the impact of preterm birth on the cardiovascular response to both heat and cold stress. Further, this dysfunction has been observed at an earlier age than that achievable using traditional stress testing techniques. The present findings warrant further investigation.

Building energy consumption in China accounts for 45% of the total national energy consumption, with air conditioning energy consumption representing approximately two-thirds of that. Therefore, energy efficiency in buildings is of utmost importance. This study focuses on a chemical industrial park located along the Fujiang River and compares three heating and cooling supply schemes: the river water source heat pump system, which utilizes river water as the heat source and heat sink; the water cooling unit and boiler system, which uses water-cooled electric compression chillers for cooling and an oil-fired boiler system for heating; and the split air conditioning and gas water heater scheme, which relies on refrigerants such as fluorine-containing compounds for cooling and a gas water heater for heating. By calculating the energy consumption of the above three schemes and conducting a comparative analysis, it is found that the river water source heat pump system exhibits significantly higher energy efficiency throughout the year compared to the water cooling unit and boiler system and the split air conditioning and gas water heater scheme. This highlights the notable energy efficiency advantage of the river water source heat pump system. [ABSTRACT FROM AUTHOR]

Climate change-induced weather events, such as extreme temperatures, prolonged drought spells, or flooding, pose an enormous risk to crop productivity. Studies on the implications of multiple stresses may vary from those on a single stress. Usually, these stresses coincide, amplifying the extent of collateral damage and contributing to significant financial losses. The breadth of investigations focusing on the response of horticultural crops to a single abiotic stress is immense. However, the tolerance mechanisms of horticultural crops to multiple abiotic stresses remain poorly understood. In this review, we described the most prevalent types of abiotic stresses that occur simultaneously and discussed them in in-depth detail regarding the physiological and molecular responses of horticultural crops. In particular, we discussed the transcriptional, posttranscriptional, and metabolic responses of horticultural crops to multiple abiotic stresses. Strategies to breed multi-stress-resilient lines have been presented. Our manuscript presents an interesting amount of proposed knowledge that could be valuable in generating resilient genotypes for multiple stressors. [ABSTRACT FROM AUTHOR]

Objective: To investigate the association between ambient temperature and preterm birth (PTB) and to estimate the population attributable fraction (PAF) of PTBs due to low and high temperatures. Design: Time‐stratified case‐crossover design. Setting: Japan (46 prefectures, excluding Okinawa), 2011–2020. Sample: 214 050 PTBs registered in the Japan Perinatal Registry Network database among 1 908 168 singleton live births. Methods: A quasi‐Poisson regression model with a distributed lag nonlinear model was employed to assess the associations between daily mean temperature and PTBs for a lag of 0–27 days in each prefecture. A random effects meta‐analysis was conducted by combining effect estimates from the 46 prefectures to estimate pooled relative risks (RRs). The PAFs of the PTBs due to below or above the mean of the 46 median temperatures (16.0°C) were calculated. Main outcome measures: Preterm singleton live births. Results: The association between daily mean temperature and PTB risk exhibited a U‐shaped curve. The adjusted RRs were 1.15 (95% confidence interval [CI] 1.05–1.25) at the mean of the 1st percentiles (0.8°C) and 1.08 (95% CI 1.00–1.17) at the mean of the 99th percentiles (30.2°C) of 46 prefectures, with 16.0°C as the reference temperature. Approximately 2.3% (95% CI 0.6–4.0) of PTBs were attributable to low temperatures. Conclusions: Both low and possibly high temperatures were associated with an increased risk of PTBs. These findings may help to inform preventive measures for pregnant women. [ABSTRACT FROM AUTHOR]

Whether the heat and cold tolerance of endotherms evolve independently or correlatively remains unresolved. Both physiological trade-offs and natural selection can contribute to a coevolutionary pattern of heat and cold tolerance in endotherms. Using a published database, we tested the correlation between upper and lower thermal limits across endothermic species with multi-response generalized linear mixed models incorporating phylogenies. We found a positive correlation between upper and lower thermal limits, which suggested a coevolutionary pattern of heat and cold tolerance. Specifically, this relationship between heat and cold tolerance is phylogenetically constrained for tropical endotherms but not for temperate endotherms. The correlated evolution between heat and cold tolerance may have a significant influence on endotherms' evolution and ecology and needs to be further investigated. [ABSTRACT FROM AUTHOR]

Musculoskeletal pain is a major burden in our society. Management of musculoskeletal pain or injuries includes both pharmacological and non-pharmacological approaches, including heat therapy (HT). HT is a well-established treatment option due to its ability to promote muscle relaxation, enhance blood circulation, and modulate nociceptors with a good safety profile. The main focus of this paper is to review the available literature about HT in knee pathologies (i.e., arthrosis, arthritis, traumatic pathologies in the subacute phase, muscle and tendon pathologies linked to fatigue, muscle tension and distractions) and to provide an expert opinion in case of lack of data.

Purpose: Ambient temperature affects endurance exercise performance. However, most research has been conducted in a laboratory-based setting, and whether there are sex-specific trends remains unclear. The present study aimed to analyze the influence of ambient temperature on cycling performance in male and female professional cyclists using field-based data collected during both training and racing. Methods: A total of 74 cyclists (48 male and 26 female; age 29 [5] y, 8 [5] y of experience in the professional category) were included in the analyses. We registered the participants' record power profile using data from both training and competitions over 8 years (2013–2020; 8 [5] seasons per cyclist). We analyzed their mean maximal power (MMP) values attained for efforts lasting 5 seconds, 30 seconds, 5 minutes, and 20 minutes at ambient temperatures ranging from <5°C to >35°C. Results: A significant influence of ambient temperature on MMP values was found in male and female cyclists (P <.001 for both), with no significant differences between sexes (P =.512). Cyclists attained the highest MMP values at temperate conditions (10–30°C in males and 5–25°C in females), whereas an impairment in performance was found at colder and hotter temperatures, particularly for the more extreme conditions (performance impairment at <5°C and >35°C of −18% to −9% and −16% to −9%, respectively). Conclusions: Ambient temperature influences field-based cycling performance, following a reverse U-shaped relationship, with the highest MMP values attained in the range of ∼10°C to 25°C and with no major differences between sexes. [ABSTRACT FROM AUTHOR]

Background Only little is known about trends in temperature–mortality associations among the most vulnerable subgroups, especially in the areas of central and eastern Europe, which are considered major climatic hotspots in terms of heatwave exposure. Thus, we aimed to assess trends in temperature-related mortality in the Czech Republic by sex, age and cause of death, and to quantify the temporal evolution of possible inequalities. Methods We collected daily time series of all-cause (1987–2019) and cause-specific (1994–2019) mortality by sex and age category, and population-weighted daily mean 2-metre temperatures for each region of the Czech Republic. We applied a quasi-Poisson regression model to estimate the trends in region-specific temperature–mortality associations, with distributed lag non-linear models and multivariate random-effects meta-analysis to derive average associations across the country. We then calculated mortality attributable to non-optimal temperatures and implemented the indicator of sex- and age-dependent inequalities. Results We observed a similar risk of mortality due to cold temperatures for men and women. Conversely, for warm temperatures, a higher risk was observed for women. Results by age showed a clear pattern of increasing risk due to non-optimum temperatures with increasing age category. The relative risk (RR) related to cold was considerably attenuated in most of the studied subgroups during the study period, whereas an increase in the RR associated with heat was seen in the overall population, in women, in the age category 90+ years and with respect to respiratory causes. Moreover, underlying sex- and age-dependent inequalities experienced substantial growth. Conclusions Our findings suggest ongoing adaptation to cold temperatures. Mal/adaptation to hot temperatures occurred unequally among population subgroups and resulted in growing inequalities between the sexes and among age categories. [ABSTRACT FROM AUTHOR]

The efficacy and safety of a single novel electronic pulp sensitivity tester with a transilluminator (PSTT) capable of providing 4 different tests was compared with gold standard (GS) pulp testing methods. Four hundred eighty teeth, including 3 from each quadrant and their contralateral and opposing teeth, were randomly assessed using the PSTT or GS methods. Seven days later, the same teeth were assessed using the method not used earlier so that all teeth were evaluated using both methods. Sixty previously root canal–treated teeth, serving as negative controls, were assessed identically to the experimental groups. Results were analyzed using IBM SPSS software (IBM Corp, Armonk, NY) (P <.05). A higher percentage of teeth responded to cold and electricity using GS methods compared with the PSTT (99.4 vs 93.1 and 99.6 vs 97.3, respectively). A lower percentage of teeth responded to heat using the GS method compared with the PSTT (50.0 vs 68.1). Chi-square tests determined differences in the proportion of sensitivity to temperature, and electric testing methods were statistically significant (P <.001 and P =.004, respectively). No difference in the proportion of sensitivity was observed for transillumination. The Wilcoxon signed rank test determined significantly shorter cold testing times using the GS method (P =.024). Shorter testing times were observed using the PSTT for heat (P <.001), electric pulp testing (P =.048), and transillumination (P =.001). The overall PSTT testing time was significantly shorter than the GS testing time (P =.03). Tissue injury was not observed. The PSTT efficiently and safely provided heat and transillumination for pulpal diagnosis. Improvements are needed to enhance the cold and electric stimulus efficacy. [ABSTRACT FROM AUTHOR]

Purpose: The present in vitro study aimed to compare the tissue dissolution ability of a 5% sodium hypochlorite solution at 3 different temperatures. Methods: Thirty standardized fragments were prepared from bovine muscle tissue and randomly divided into 3 experimental groups (n = 10) according to the temperature of the sodium hypochlorite. The tissue was immersed in a 1.5-mL test tube containing 20 mL of sodium hypochlorite at the specific temperature and stored for 15 min. The solution was agitated with an ultrasonic tip working for 1 min. Then the solution was filtered, and the tissue sample was dried. The weight loss of the tissue was measured as dissolved tissue by the sodium hypochlorite. A one-way analysis of variance was used to compare the mean dissolved tissue weight between groups (p < 0.05). Results: The highest dissolution values were found in the 60°C sodium hypochlorite group, achieving significantly greater mass loss (p < 0.05), while no significant difference was found between the solutions applied at 20°C and 2.5°C (p > 0.05). Conclusion: This in vitro study found that the application of sodium hypochlorite by cooling for cryotherapy did not alter its capacity for dissolving organic tissue compared to application at room temperature. [ABSTRACT FROM AUTHOR]

Temporal change in heat and cold-related burden of mortality needs to be investigated in Iran. In this study, the burden between 2015 and 2022 was compared with 2008–2014 in eight cities of Kurdistan which is located to the west of Iran. The overall dose–response association between temperature and mortality by different years (i.e., interaction effect between year and temperature) was assessed using bivariate response surface model and the framework of generalized additive model (GAM). The cumulative dose–response as well as lag-response associations in the two periods was compared by a time-varying distributed lag non-linear model. The associations were pooled using a two-stage regression model in which average temperature and temperature range were adjusted to control for the heterogenicity between cities. The attributable fraction (AF) and number (AN) were estimated in each city to ease the interpretation. Compared to 2008–2014, heat and extreme heat caused more mortality than cold and extreme cold in 2015–2022; the relative risk (RR) values of heat in second period were significantly higher than first period, and the cumulative RR of the extreme heat was 1.56 (%95 CI: 1.23–1.98) and 0.88 (%95 CI: 0.66–1.18) in second and first periods, respectively. Also, the cumulative RR of extreme cold was 1.01 (0.87, 1.17) and 0.89 (0.76, 1.05) in second and first periods, respectively. In second period, the extreme heat values approximately caused a minimum of 100 deaths in Marivan and a maximum of 400 in Sanandaj. The AF in Baneh, Kamyaran, and Sanandaj was significantly higher than other cities. All subgroups' people were at risk of heat-related mortality in second period, and the cold had no significant impact in the period. Heat-related mortality was increased in recent years while cold had no significant impact. The results highlight the need for an adaptation or preventive strategy of heat-related mortality in the regions. [ABSTRACT FROM AUTHOR]

This document explores the impact of environmental stress, specifically heat stress and low light conditions, on plant reproduction. It discusses studies conducted on different plant species to understand the effects of these stresses on reproductive organs and processes. The studies reveal that heat stress can lead to abnormalities in anther development, reduced pollen viability, and altered gene expression related to carbohydrate metabolism. Low light conditions delay flowering, reduce pollen viability and stigma receptivity, and affect seed quality. The findings provide insights into the physiological and molecular mechanisms underlying plant reproductive responses to environmental stresses. [Extracted from the article]

In the present study, we examined the effect of extreme temperatures on different life stages of Ephestia kuehniella Zeller (Lepidoptera: Pyralidae). The individuals were exposed to different temperatures ranging between 5 and −18 °C for cold treatment, and between 30 and 55 °C for heat treatment, and different exposure intervals, ranging from minutes to days. Complete control was achieved at −10 and −15 °C for cold treatment and 50 and 55 °C for heat treatment at all exposure intervals. Considering the efficacy of extreme temperatures for the control of E. kuehniella, our study provides specific temperature exposure modules that can be effective for the control of this species.

Context: Warming up in very cold climates and maintaining an elevated body temperature prior to a race is challenging for snow-sport athletes. Purpose: To investigate the effects of active (ACT), passive (PAS), and a combination of ACT and PAS (COM) warm-ups on maximal physical performance in a subzero environment among snow-sport athletes. Methods: Ten junior alpine skiers completed 3 experimental trials in −7.2 (0.2)°C. The ACT involved 5 minutes of moderate cycling, 3 × 15-second accelerations, a 6-second sprint, 5 countermovement jumps (CMJs), and a 10-minute passive transition phase, while in PAS, participants wore a lower-body heated garment for 24 minutes. In COM, participants completed the active warm-up, then wore the heated garment during the transition phase. Two maximal CMJs and a 90-second maximal isokinetic cycling test followed the warm-up. Results: CMJ performance was likely (P =.150) and very likely (P =.013) greater in ACT and COM, respectively, versus PAS. Average power output during the cycling test was likely (P =.074) greater in ACT and COM versus PAS. Participants felt likely to almost certainly warmer (P <.01) and more comfortable (P =.161) during ACT and COM versus PAS. In addition, participants felt likely warmer (P =.136) and very likely more comfortable (P =.161) in COM versus ACT. Conclusions: COM resulted in significantly improved CMJ performance versus PAS while both ACT and COM led to likely improved 90-second cycling performance. Participants felt significantly warmer during ACT and COM versus PAS and likely warmer in COM versus ACT. Therefore, a combined warm-up is recommended for alpine skiers performing in subzero temperatures. [ABSTRACT FROM AUTHOR]

ABSTRACTBackground: Hypertensive disorders in pregnancy (HDP) are a major cause of maternal mortality and morbidity. Recent studies indicated that pregnant women are the most vulnerable populations to ambient temperature influences, but it affected HDP with inconsistent conclusions. Our objective is to systematically review whether extreme temperature exposure is associated with a changed risk for HDP. Method: We searched PubMed, EMBASE, Web of Science and Cochrane Library databases. We included cohort or case control studies examining the association between extreme temperature exposure before or during pregnancy and HDP. Heat sources such as saunas and hot baths were excluded. We pooled the odds ratio (OR) to assess the association between extreme temperature exposure and preeclampsia or eclampsia. Results: Fifteen studies involving 4,481,888 patients were included. Five studies were included in the meta-analysis. The overall result demonstrated that in the first half of pregnancy, heat exposure increases the risk of developing preeclampsia or eclampsia and gestational hypertension, and cold exposure decreases the risk. The meta-analysis revealed that during the first half of pregnancy, heat exposure increased the risk of preeclampsia or eclampsia (OR 1.54, 95% confidence interval (CI): 1.10, 2.15), whereas cold exposure decreased the risk (OR 0.90, 95% CI: 0.84, 0.97). Conclusion: The ambient temperature is an important determinant for the development of HDP, especially for preeclampsia or eclampsia. The effects of extreme temperatures may be bidirectional during the different trimesters of pregnancy, which should be evaluated by future studies. This review provided hints of temperature regulation in HDP administration.

Under climate change, many parts of the world are warming with increasing frequencies and intensities of heatwaves, bringing heat-health risks to places including those that have a historically temperate or cool climate. These places may have extensive experience in managing cold-health risks, while experience is lacking in dealing with heat-health risks due to their lack of historical exposure to high temperatures. This paper explores this overlooked area of the challenges and opportunities of heat-health governance in cool places using Scotland as a case study. Various important themes of heat-health governance in cool places were identified by the study, including socio-cultural barriers to intervention, vulnerable population overlaps, temporal and geographical scales, and governance arrangements. The study found challenges in managing heat-health risks including a perceived lack of heat-health risks and policy priority as well as unsuitable building stock. Meanwhile, it also identified opportunities for governing cold and heat risks holistically within existing institutional systems and creating co-benefits of improving communication and information dissemination, reducing inequality and improving indoor thermal comfort of both cold and heat as well as providing good quality greenspace. Our findings contribute to the development or improvement of national/regional strategies to manage heat-health risks not only in Scotland but also in other places with a historically cool or temperate climate. • Temperature increase under climate change poses health risks to cool places as well. • Cool places have distinctive challenges and opportunities in heat-health governance. • Perceived lack of heat risks poses socio-cultural barriers to heat-health governance. • A holistic governance approach of cold and heat-health risks was preferred. • Building design and occupant behaviour are crucial for thermal comfort. [ABSTRACT FROM AUTHOR]

Climate change-induced weather events, such as extreme temperatures, prolonged drought spells, or flooding, pose an enormous risk to crop productivity. Studies on the implications of multiple stresses may vary from those on a single stress. Usually, these stresses coincide, amplifying the extent of collateral damage and contributing to significant financial losses. The breadth of investigations focusing on the response of horticultural crops to a single abiotic stress is immense. However, the tolerance mechanisms of horticultural crops to multiple abiotic stresses remain poorly understood. In this review, we described the most prevalent types of abiotic stresses that occur simultaneously and discussed them in in-depth detail regarding the physiological and molecular responses of horticultural crops. In particular, we discussed the transcriptional, posttranscriptional, and metabolic responses of horticultural crops to multiple abiotic stresses. Strategies to breed multi-stress-resilient lines have been presented. Our manuscript presents an interesting amount of proposed knowledge that could be valuable in generating resilient genotypes for multiple stressors.

This document is an editorial published in Frontiers in Physiology titled "Cold, heat and hypoxia as a medical tool: the use in a healthy and diseased population." The editorial discusses the potential benefits of intentional exposure to environmental stressors such as cold, heat, and hypoxia for enhancing health and well-being. The concept of hormesis, where controlled exposure to mild stressors triggers adaptive responses in the body, is explored. The editorial highlights various studies that investigate the physiological effects of these stressors and their potential therapeutic applications. It emphasizes the need for further research to fully understand the physiological impact of these environmental stressors. [Extracted from the article]

Abiotic stresses such as drought and heat continue to impact crop production in a warming world. This review distinguishes seven inherent capacities that enable plants to respond to abiotic stresses and continue growing, although at a reduced rate, to achieve a productive yield. These are the capacities to selectively take up essential resources, store them and supply them to different plant parts, generate the energy required for cellular functions, conduct repairs to maintain plant tissues, communicate between plant parts, manage existing structural assets in the face of changed circumstances, and shape-shift through development to be efficient in different environments. By illustration, we show how all seven plant capacities are important for reproductive success of major crop species during drought, salinity, temperature extremes, flooding, and nutrient stress. Confusion about the term 'oxidative stress' is explained. This allows us to focus on the strategies that enhance plant adaptation by identifying key responses that can be targets for plant breeding. [ABSTRACT FROM AUTHOR]

Lipid droplet (LD) in vegetative tissues has recently been implicated in environmental responses in plants, but its regulation and its function in stress tolerance are not well understood. Here, we identified a Membrane Occupation and Recognition Nexus 1 (MORN1) gene as a contributor to natural variations of stress tolerance through genome‐wide association study in Arabidopsis thaliana. Characterization of its loss‐of‐function mutant and natural variants revealed that the MORN1 gene is a positive regulator of plant growth, disease resistance, cold tolerance, and heat tolerance. The MORN1 protein is associated with the Golgi and is also partly associated with LD. Protein truncations that disrupt these associations abolished the biological function of the MORN1 protein. Furthermore, the MORN1 gene is a positive regulator of LD abundance, and its role in LD number regulation and stress tolerance is highly linked. Therefore, this study identifies MORN1 as a positive regulator of LD abundance and a contributor to natural variations of stress tolerance. It implicates a potential involvement of Golgi in LD biogenesis and strongly suggests a contribution of LD to diverse processes of plant growth and stress responses. [ABSTRACT FROM AUTHOR]

Background Ambient temperature, particularly heat, is increasingly acknowledged as a trigger for preterm delivery but study designs have been limited and results mixed. We aimed to comprehensively evaluate the association between ambient temperature throughout pregnancy and preterm delivery. Methods We estimated daily temperature throughout pregnancy using a cutting-edge spatiotemporal model for 5347 live singleton births from three prospective cohorts in France, 2002–2018. We performed Cox regression (survival analysis) with distributed lags to evaluate time-varying associations with preterm birth simultaneously controlling for exposure during the first 26 weeks and last 30 days of pregnancy. We examined weekly mean, daytime, night-time and variability of temperature, and heatwaves accounting for adaptation to location and season. Results Preterm birth risk was higher following cold (5th vs 50th percentile of mean temperature) 7–9 weeks after conception [relative risk (RR): 1.3, 95% CI: 1.0–1.6 for 2°C vs 11.6°C] and 10–4 days before delivery (RR: 1.6, 95% CI: 1.1–2.1 for 1.2°C vs 12.1°C). Night-time heat (95th vs 50th percentile of minimum temperature; 15.7°C vs 7.4°C) increased risk when exposure occurred within 5 weeks of conception (RR: 2.0, 95% CI: 1.05–3.8) or 20–26 weeks after conception (RR: 2.9, 95% CI: 1.2–6.8). Overall and daytime heat (high mean and maximum temperature) showed consistent effects. We found no clear associations with temperature variability or heatwave indicators, suggesting they may be less relevant for preterm birth. Conclusions In a temperate climate, night-time heat and chronic and acute cold exposures were associated with increased risk of preterm birth. These results suggest night-time heat as a relevant indicator. In the context of rising temperatures and more frequent weather hazards, these results should inform public health policies to reduce the growing burden of preterm births. [ABSTRACT FROM AUTHOR]

Abstract Background Physical activity (PA) can be affected by extreme temperatures, however fewer studies have identified factors impacting this relationship. This study sought to identify factors associated with changes of outdoor PA during extreme cold/heat events in a sub-tropical Chinese urban population, including factors of sociodemographic, health conditions, temperature-related awareness and attitude, and protective behaviours. Methods Two telephone surveys were conducted a week after extreme cold/heat events in 2016 and 2017 among a cohort of Hong Kong residents over age 15. Data was collected on self-reported changes in outdoor PA level during the periods of extreme temperatures, health status, comorbidities, sociodemographic, and temperature-related awareness, and behavioural variables. We conducted multivariable logistic regression analyses to assess predictors of change in outdoor PA over the two extreme temperature events. Results and Conclusion: Among 435 participants (42.8% response rate), over a third of the participants reported decreased outdoor PA level in extreme temperature events, while 10% reported an increase in extreme heat. Self-reported cardiovascular diseases were associated with decreased PA level in extreme cold, while hypertension was associated with unchanged/increased PA level in extreme heat. These results suggest physical activity to be an important consideration in the understanding of climate change-and-health pathways and meriting further research.

The continuously changing environment has led to devastating effects on the normal growth and development of plants. This necessitates the understanding of different components that can be involved in alleviating these effects. In the last two decades, nitric oxide (NO) has been largely focused on as a molecule whose endogenous production and exogenous supply lead to several molecular and physiological changes in plants under stressed conditions. Although its role as a signaling molecule in endogenous production has been largely discussed, its function in dealing with contemporary abiotic stress conditions on exogenous supply remains comparatively less explored. There is growing evidence that NO plays a critical role in many physiological processes; however, there is debate about the exact mechanism(s) through which NO lessens abiotic stress on external supply. In this review, we discuss the studies that were focused on observing the effect of exogenous NO on different abiotic stresses including heavy metal stress, element deficiency or toxicity stress, salt stress, drought stress, ultraviolet radiation stress, waterlogging stress, and chilling stress. Though the positive effects of endogenous NO have been discussed in brief in different sections, the focus of the review is to discuss the effects of exogenous NO on plant grown under abiotic stresses. Deciphering the underlying mechanism of exogenous NO treatment may open up new ideas that can suggest the successful application of NO in agricultural regions to reduce the damaging influences of different abiotic stresses. [ABSTRACT FROM AUTHOR]

Context: Documenting trends in the health impacts of ambient temperature is key to supporting adaptation strategies to climate change. This paper explores changes in the temperature-related mortality in 18 French urban centers between 1970 and 2015. Method: A multicentric time-series design with time-varying distributed lag nonlinear models was adopted to model the shape of the relationship and assess temporal changes in risks and impacts. Results: The general shape of the temperature-mortality relationship did not change over time, except for an increasing risk at very low percentiles and a decreasing risk at very high percentiles. The relative risk at the 99.9th percentile compared to the 50th percentile of the 1970–2015 temperature distribution decreased from 2.33 [95% confidence interval (CI): 1.95:2.79] in 1975 to 1.33 [95% CI: 1.14:1.55] in 2015. Between 1970 and 2015, 302,456 [95% CI: 292,723:311,392] deaths were attributable to non-optimal temperatures, corresponding to 5.5% [95% CI: 5.3:5.6] of total mortality. This burden decreased progressively, representing 7.2% [95% CI: 6.7:7.7] of total mortality in the 1970s to 3.4% [95% CI: 3.2:3.6] in the 2000s. However, the contribution of hot temperatures to this burden (higher than the 90th percentile) increased. Discussion: Despite the decreasing relative risk, the fraction of mortality attributable to extreme heat increased between 1970 and 2015, thus highlighting the need for proactive adaptation. [ABSTRACT FROM AUTHOR]

Abiotic stresses triggered by climate change and human activity cause substantial agricultural and environmental problems which hamper plant growth. Plants have evolved sophisticated mechanisms in response to abiotic stresses, such as stress perception, epigenetic modification, and regulation of transcription and translation. Over the past decade, a large body of literature has revealed the various regulatory roles of long non-coding RNAs (lncRNAs) in the plant response to abiotic stresses and their irreplaceable functions in environmental adaptation. LncRNAs are recognized as a class of ncRNAs that are longer than 200 nucleotides, influencing a variety of biological processes. In this review, we mainly focused on the recent progress of plant lncRNAs, outlining their features, evolution, and functions of plant lncRNAs in response to drought, low or high temperature, salt, and heavy metal stress. The approaches to characterize the function of lncRNAs and the mechanisms of how they regulate plant responses to abiotic stresses were further reviewed. Moreover, we discuss the accumulating discoveries regarding the biological functions of lncRNAs on plant stress memory as well. The present review provides updated information and directions for us to characterize the potential functions of lncRNAs in abiotic stresses in the future. [ABSTRACT FROM AUTHOR]

The potential critical windows for extreme ambient temperature, air pollution exposure and small for gestational age (SGA) are still unclear, and no study has explored their joint effects on SGA. In a national multi-center prospective cohort, we included 179,761 pairs of mother-infant from 16 counties of 8 provinces in China during 2014–2018. Daily averaged temperature and PM2.5 concentration were matched to the maternal residential address to estimate personal exposure. Extreme temperature exposures were categorized by a series of percentile in each meteorological and geographic division for the entire pregnancy, each trimester and gestational week (GA-week). Generalized linear mixed models (GLMMs) and distributed lag nonlinear models (DLNMs) were used to estimate the whole pregnancy-, trimester-specific, and weekly-specific associations of extreme temperature and PM2.5 exposures with SGA. Combined effects were evaluated with the relative excess risk due to interaction (RERI) and proportion attributable to interaction (AP). We observed that by referring to temperature at the 41st − 50th percentile, heat (>90th percentile) exposure during 13th − 29th GA-weeks was associated with SGA; odds ratio (OR) and 95 % confidence intervals (CI) was 1.16 (1.06, 1.28). For cold (

Background: Hypertensive disorders in pregnancy (HDP) are a major cause of maternal mortality and morbidity. Recent studies indicated that pregnant women are the most vulnerable populations to ambient temperature influences, but it affected HDP with inconsistent conclusions. Our objective is to systematically review whether extreme temperature exposure is associated with a changed risk for HDP. Method: We searched PubMed, EMBASE, Web of Science and Cochrane Library databases. We included cohort or case control studies examining the association between extreme temperature exposure before or during pregnancy and HDP. Heat sources such as saunas and hot baths were excluded. We pooled the odds ratio (OR) to assess the association between extreme temperature exposure and preeclampsia or eclampsia. Results: Fifteen studies involving 4,481,888 patients were included. Five studies were included in the meta-analysis. The overall result demonstrated that in the first half of pregnancy, heat exposure increases the risk of developing preeclampsia or eclampsia and gestational hypertension, and cold exposure decreases the risk. The meta-analysis revealed that during the first half of pregnancy, heat exposure increased the risk of preeclampsia or eclampsia (OR 1.54, 95% confidence interval (CI): 1.10, 2.15), whereas cold exposure decreased the risk (OR 0.90, 95% CI: 0.84, 0.97). Conclusion: The ambient temperature is an important determinant for the development of HDP, especially for preeclampsia or eclampsia. The effects of extreme temperatures may be bidirectional during the different trimesters of pregnancy, which should be evaluated by future studies. This review provided hints of temperature regulation in HDP administration. [ABSTRACT FROM AUTHOR]

Background: Physical activity (PA) can be affected by extreme temperatures, however fewer studies have identified factors impacting this relationship. This study sought to identify factors associated with changes of outdoor PA during extreme cold/heat events in a sub-tropical Chinese urban population, including factors of sociodemographic, health conditions, temperature-related awareness and attitude, and protective behaviours. Methods: Two telephone surveys were conducted a week after extreme cold/heat events in 2016 and 2017 among a cohort of Hong Kong residents over age 15. Data was collected on self-reported changes in outdoor PA level during the periods of extreme temperatures, health status, comorbidities, sociodemographic, and temperature-related awareness, and behavioural variables. We conducted multivariable logistic regression analyses to assess predictors of change in outdoor PA over the two extreme temperature events. Results and Conclusion: Among 435 participants (42.8% response rate), over a third of the participants reported decreased outdoor PA level in extreme temperature events, while 10% reported an increase in extreme heat. Self-reported cardiovascular diseases were associated with decreased PA level in extreme cold, while hypertension was associated with unchanged/increased PA level in extreme heat. These results suggest physical activity to be an important consideration in the understanding of climate change-and-health pathways and meriting further research. [ABSTRACT FROM AUTHOR]

Cauliflower is one of the most important popular vegetables in China. Cauliflower (Brassica oleracea L. var. botrytis) produces glucosinolates, which are secondary metabolites that have anti-cancer properties. The choice of suitable reference genes (RGs) for gene expression studies has a significant effect on experimental outcomes. In this study, we selected 15 candidates as RGs and analyzed them under heat, cold, drought, and salt stresses and methyl jasmonate (MeJA) treatment. The precision of the real-time quantitative polymerase chain reaction data was assessed using four methods (geNorm, NormFinder, BestKeeper, and ΔCt). The results revealed that EF1-ß and ACT7; ACT1, EF1-ß, and TUB6; TUA2 and EF1-ß; HIS and ACT7; and ACT7 and ACT3 were the most stable combinations of genes for heat stress, cold stress, drought stress, salt stress, and MeJA treatment, respectively. The expression stability of the RGs fluctuated under different experimental conditions. Choosing the optimal RG for the specific experiment is therefore essential. This work provides relevant information for further gene expression studies on cauliflower and other closely related species. [ABSTRACT FROM AUTHOR]

Extreme weather events can cause significant human, economic and infrastructure losses. Within a changing climate, heatwaves, droughts, and floods are becoming more frequent and severe. Unfortunately, those who are most vulnerable are often disproportionately impacted. In this study, we examined the epidemiology of weather-related fatalities due to excessive heat (International Classification of Diseases [ICD]-10 codes X30); excessive cold (X31); storm and flood (X37; X38); and other causes (X32, X33, X39) in Australia between 2006–2019. There were 682 deaths due directly to weather-related events (41% excessive cold; 37% excessive heat; 15% storms and floods). The mean age of a weather-related victim in Australia was 60.8 years (SD = 24.1), with people aged 65+ years 12.8 times (95% confidence interval [CI]: 9.23–17.6) more likely to die due to a weather-related event. As the planet warms our study identifies declining excessive cold-related deaths, while other types of weather events remain steady or increase. In the context of climate change we must protect those most at risk; children and adolescents due to storms and floods, those with co-morbidities (particularly circulatory system disorders) and the elderly. Special attention should be paid to preventing excessive heat-related death among Aboriginal and Torres Strait Islander Peoples and international visitors. [ABSTRACT FROM AUTHOR]

Wheat represents one of the most important staple food crops worldwide and its genetic improvement is fundamental to meeting the global demand of the growing population. However, the environmental stresses, worsened by climate change, and the increasing deterioration of arable land make it very difficult to fulfil this demand. In light of this, the tolerance of wheat to abiotic stresses has become a key objective of genetic improvement, as an effective strategy to ensure high yields without increasing the cultivated land. Genetic erosion related to modern agriculture, whereby elite, high-yielding wheat varieties are the product of high selection pressure, has reduced the overall genetic diversity, including the allelic diversity of genes that could be advantageous for adaptation to adverse environmental conditions. This makes traditional breeding a less effective or slower approach to generating new stress-tolerant wheat varieties. Either mining for the diversity of not-adapted large germplasm pools, or generating new diversity, are the mainstream approaches to be pursued. The advent of genetic engineering has opened the possibility to create new plant variability and its application has provided a strong complement to traditional breeding. Genetic engineering strategies such as transgenesis and genome editing have then provided the opportunity to improve environmental tolerance traits of agronomic importance in cultivated species. As for wheat, several laboratories worldwide have successfully produced transgenic wheat lines with enhanced tolerance to abiotic stresses, and, more recently, significant improvements in the CRISPR/Cas9 tools available for targeted variations within the wheat genome have been achieved. In light of this, the present review aims to provide successful examples of genetic engineering applications for the improvement of wheat adaptation to drought, salinity and extreme temperatures, which represent the most frequent and most severe events causing the greatest losses in wheat production worldwide. [ABSTRACT FROM AUTHOR]

Cauliflower is one of the most important popular vegetables in China. Cauliflower (Brassica oleracea L. var. botrytis) produces glucosinolates, which are secondary metabolites that have anti-cancer properties. The choice of suitable reference genes (RGs) for gene expression studies has a significant effect on experimental outcomes. In this study, we selected 15 candidates as RGs and analyzed them under heat, cold, drought, and salt stresses and methyl jasmonate (MeJA) treatment. The precision of the real-time quantitative polymerase chain reaction data was assessed using four methods (geNorm, NormFinder, BestKeeper, and ΔCt). The results revealed that EF1-β and ACT7; ACT1, EF1-β, and TUB6; TUA2 and EF1-β; HIS and ACT7; and ACT7 and ACT3 were the most stable combinations of genes for heat stress, cold stress, drought stress, salt stress, and MeJA treatment, respectively. The expression stability of the RGs fluctuated under different experimental conditions. Choosing the optimal RG for the specific experiment is therefore essential. This work provides relevant information for further gene expression studies on cauliflower and other closely related species.