1. Congestive heart failure: a case of protein misfolding.
- Author
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Ha CE, Bhagavan NV, Loscalzo M, Chan SK, Nguyen HV, Rios CN, and Honda SA
- Subjects
- Aged, Amyloidosis diagnosis, Heart Failure diagnosis, Humans, Male, Proteostasis Deficiencies diagnosis, Amyloidosis etiology, Heart Failure etiology, Multiple Myeloma, Proteostasis Deficiencies complications
- Abstract
This article describes an interesting case of a patient presenting with congestive heart failure found to have restrictive cardiomyopathy with initial laboratory evaluation showing hypogammaglobuminemia without a monoclonal band on serum and urine electrophoresis. This case highlights the clinically significant cardiac manifestation caused by protein misfolding, a defect in protein homeostasis. In addition, the utility of a relatively newer laboratory test, serum free light chains as well as the importance of clinical and pathophysiologic correlation is also discussed. We present a relatively uncommon cause of heart disease, cardiac amyloidosis in a patient with a systemic plasma cell dyscrasia, and multiple myeloma.
- Published
- 2014