1. The Pathobiology of Myocardial Recovery and Remission: From Animal Models to Clinical Observations in Heart Failure Patients.
- Author
-
Park AC and Mann DL
- Subjects
- Humans, Animals, Myocardium pathology, Treatment Outcome, Remission Induction, Heart Failure physiopathology, Heart Failure therapy, Recovery of Function, Ventricular Function, Left, Ventricular Remodeling, Disease Models, Animal, Stroke Volume
- Abstract
Heart failure with reduced left ventricular (LV) ejection fraction (HFrEF) is a morbid and life-threatening disease, arising secondary to abnormalities of cardiac structure and function that lead to adverse LV remodeling. Implementation of medical and device therapies results in significant improvements in patient outcomes that are associated with reverse LV remodeling and improved LV ejection fraction. This review provides an overview of the pathobiology of reverse LV remodeling in animal models and in HFrEF patients. We emphasize the differences between myocardial recovery and remission as well as the fragile nature of maintaining a state of myocardial remission., Competing Interests: The authors have no competing interests to declare., (Copyright: © 2024 The Author(s).)
- Published
- 2024
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