1. Birth weight, length and head circumference: Progression and impact over the outcome of patients with congenital heart disease.
- Author
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Silveira DB, da Rosa EB, Correia JD, Trevisan P, Fiegenbaum M, Oliveira CA, Grapiglia CG, Nunes MR, Rosa RCM, Zen TD, Zen PRG, and Rosa RFM
- Subjects
- Brazil epidemiology, Female, Heart Defects, Congenital diagnosis, Heart Defects, Congenital mortality, Hospitalization trends, Humans, Infant, Infant, Newborn, Male, Prospective Studies, Treatment Outcome, Birth Weight physiology, Body Height physiology, Disease Progression, Head growth & development, Heart Defects, Congenital physiopathology
- Abstract
Background: There are few studies assessing the birth measures of patients with congenital heart disease (CHD). Our aim to evaluate their progression and impact over the outcome., Methods: The cases consisted of patients with CHD during their first hospitalization in a reference cardiac and pediatric intensive care unit (ICU) from Southern Brazil. Controls were composed of patients with no clinical evidence of CHD hospitalized soon after cases. The cases underwent high-resolution karyotype and fluorescence in situ hybridization (FISH) for 22q11 microdeletion. We analyzed birth weight, length and head circumference of patients of both groups. For CHD patients, we evaluated their progression and impact until hospitalization at ICU., Results: Our sample was composed of 198 cases and controls. We observe a difference in birth weight of CHD patients only in relation to general population. There was a significant increase in children with CHD and weight below the lower limit from birth until the hospitalization at ICU, and this occurred more in those without complex CHD. Syndromic patients and with an extracardiac malformation also presented a greater difficulty to maintain not only the weight but also the length/height until the hospitalization. Individuals with weight below the lower limit at hospitalization who died had a tendency to present longer stay at ICU., Conclusions: Some CHD patients, especially without complex defects, and with syndromic aspect and a major extracardiac malformation, present a higher difficult to maintain their weight and growth, and, therefore, may be at risk and should be more closely monitored., (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Published
- 2017
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