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Copyright of Medizinische Klinik: Intensivmedizin & Notfallmedizin is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The current S1 guidelines on the intraoperative clinical application of hemodynamic monitoring in patients scheduled for noncardiac surgery are presented based on a case report under the aspect of an optimized intraoperative anesthesiological management. The S1 guidelines were developed with the aim of identifying the questions on the intraoperative hemodynamic monitoring and management which are important for the routine daily clinical practice, to discuss them in a guideline group and to answer them based on the current state of scientific knowledge. The guidelines were written under the auspices of the German Society of Anesthesiology and Intensive Care Medicine (DGAI) and published by the AWMF in 2023 under the register number 001/049. [ABSTRACT FROM AUTHOR]

Copyright of Medizinische Klinik: Intensivmedizin & Notfallmedizin is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In both equestrian sports and alternative husbandry horses are more and more used as draft animal. Also in draft horses an efficiant power transmission plays an important role in regard to the animal’s wellbeing. The aim of the study was to classify the performance of working horses regarding their physical and psychological stress. Two defined traction forces (1300 N and 2600 N = target values) were continuously recorded during a load lasting for 30 min each in two pairs of Freiberger horses each on the braked and loaded carriage. The tractive forces that were recorded corresponded to the actual values. The work performed by the horses was assessed. Heart rate was recorded using POLAR training watches (V800). To assess the workload including a possible psychological component, blood samples were additionally taken before, during, and after work (0, 15, 30, and 60 min) in which cortisol, glucose, and non-esterified fatty acids (NEFA) were determined. Data analysis was done in a descriptive and statistical manner (paired t-test, Pearson correlation coefficient, using the statistical program R, significance level was p < 0.05). The average tensile forces were satisfactorily in accordance with the target values (1300 N and 2600 N, respectively): actual value pair 1/2: 1148 N and 2543 N, respectively, actual value pair 3/4: 1236 N and 2538 N, respectively. Traction forces and speeds resulted in traction powers of 813 and 2095 watts (1.11 and 2.85 horse power = hp) for each horse of pair 1/2 and 919 and 1934 watts (1.25 and 2.63 hp) for each horse of pair 3/4, respectively. Heart rates ranged from 94–124/min for both pairs at 1300 N and 124–171/min at 2600 N. Heart rates decreased by 50 % 60 sec after 15 min of work at 1300 N, and recovery times increased with longer and more intense work. At the tensile forces in the present work, glucose values of 4.79 mmol/l were measured on average for all horses at 1300 N and values of 4.68 mmol/l were measured at 2600 N. In the case of the older French mountain horse pair of carriage 3/4, an initial drop in blood glucose and a subsequent rise were more pronounced than in the French mountain horse pair of carriage 1/2. The older French mountain horses of carriage 3/4 were fed exclusively hay, while the horses of carriage 1/2 received an additional 2 kg of concentrates per day. The extent to which the low concentrate supplementation of the horses of the carriage 1/2 influenced the glucose metabolism remains speculative. The four French mountain horses achieved average NEFA values of 0.30 mmol/l at 1300 N and 0.53 mmol/l at 2600 N. At a traction level of 1300 N, plasma cortisol levels for the four French mountain horses ranged from 29.3–50.3 ng/ml, and at the traction level of 2600 N, plasma cortisol levels ranged from 24.8–58.8 ng/ml. In comparison, the values were higher in a previous study, where the average plasma cortisol values of nine Warmblood driving horses after 30–40 min of intensive training ranged from 60.72 ± 9.51 to 63.66 ± 10.07 ng/ml (Krumrych et al. 2018). Cortisol (nmol/l), glucose (mmol/), and NEFA (mmol/l) values in the present study indicated moderate to heavy work intensities. Cortisol levels correlated significantly (p < 0.05) with heart rate (r = 0.64) and NEFA (r = 0.53), indicating balanced activation of the adrenergic system and hypothalamic-pituitary-adrenal (HPA) axis and suggesting a psychological stress component as unlikely. [ABSTRACT FROM AUTHOR]

Copyright of Herz is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Medizinische Klinik: Intensivmedizin & Notfallmedizin is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Herz is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of German Journal of Sports Medicine / Deutsche Zeitschrift fur Sportmedizin is the property of Verein zur Forderung der Sportmedizin Hannover e.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Herz is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: Hypotensive states that require fast stabilisation of blood pressure can occur during anaesthesia. In 1963, the 20:1 mixture of cafedrine/theodrenaline (Akrinor) was introduced in Germany for use in anaesthesia and emergency medicine in the first-line management of hypotensive states. Though on the market for many years, few pharmacodynamic data are available on this combination net beta-mimetic agent. Aim: This study aimed to examine the drug combination in real-life clinical practice and recorded time to 10 % mean arterial blood pressure (MAP) increase and heart rate. Furthermore, potential factors that influence drug effectiveness under anaesthesia were assessed. Methods: Data were collected within a standardised anaesthesia protocol. A total of 353 consecutive patients (female/male = 149/204) who received cafedrine/theodrenaline after a drop in MAP ≥ 5 % were included in the study. The time to 10 % increase in MAP, dosage of cafedrine/theodrenaline, volume loading, blood pressure and heart rate were monitored over time. Results: Patients were a mean (standard deviation) of 64.4 ± 15.1 years old with a baseline MAP of 82 ± 14 mmHg, which dropped to a mean of 63 ± 10 mmHg during anaesthesia without gender differences. Cafedrine/theodrenaline (1.27 ± 1.0 mg/kg; 64 ± 50 µg/kg) significantly increased MAP ( p < 0.001) by 11 ± 16 mmHg within 5 min, reaching peak values within 17.4 ± 9.0 min. Heart rate was not affected in a clinically significant manner. Cafedrine/theodrenaline induced a 10 % MAP increase after 7.2 ± 4.6 min (women) and after 8.6 ± 6.3 min (men) ( p = 0.018). Independent of gender, the dose of cafedrine/theodrenaline required to achieve the observed MAP increase of 14 ± 16 mmHg at 15 min was significantly different in patients with heart failure [1.78 ± 1.67 mg/kg (cafedrine)/89.0 ± 83.5 µg/kg (theodrenaline)] compared with healthy patients [1.16 ± 0.77 mg/kg (cafedrine)/58.0 ± 38.5 µg/kg (theodrenaline)] ( p = 0.005). Concomitant medication with beta-blocking agents significantly prolonged the time to 10 % MAP increase [9.0 ± 7.0 vs. 7.3 ± 4.3 min ( p = 0.008)]. Conclusion: Cafedrine/theodrenaline quickly restores MAP during anaesthesia. Female gender is associated with higher effectiveness, while heart failure and beta-blocker administration lower the anti-hypotonic effect. Prospective studies in defined patient populations are warranted to further characterise the effect of cafedrine/theodrenaline. [ABSTRACT FROM AUTHOR]

Copyright of SportLogia is the property of University Banja Luka, Faculty of Physical Education & Sports and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)