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Your search keyword '"Catherine Garcia"' showing total 5 results
Start Over Author "Catherine Garcia" Topic health policy
5 results on '"Catherine Garcia"'

1. Analysis of Alzheimer Disease Plasma Biomarker pTau‐181 in Individuals of Diverse Admixed Ancestral Backgrounds

Author

Timo Grimmer, Farid Rajabli, Catherine Garcia‐Serje, Jamie Arvizu, Emma Larkin‐Gero, Patrice L. Whitehead, Kara L. Hamilton‐Nelson, Larry D. Adams, Maricarmen Contreras, Jose Javier Sanchez, Sergio Tejada, Pedro Ramon Mena, Takiyah D. Starks, Mario Cornejo‐Olivas, Maryenela Illanes‐Manrique, Concepcion Silva‐Vergara, Michael L. Cuccaro, Jeffery M. Vance, Briseida E. Feliciano‐Astacio, Goldie S. Byrd, Gary W. Beecham, Jonathan L. Haines, and Margaret A. Pericak‐Vance

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2022

2. Assessment of AD‐related plasma biomarkers in diverse ancestral populations

Author

Anthony J. Griswold, Farid Rajabli, Catherine Garcia‐Serje, Kara L. Hamilton‐Nelson, Larry D. Adams, Sergio Tejada, Pedro Ramon Mena, Takiyah D. Starks, Patrice L. Whitehead, Concepcion Silva‐Vergara, Michael L. Cuccaro, Izri Martinez, Maryenela Illanes‐Manrique, Mario R. Cornejo‐Olivas, Renee A. Laux, Laura J. Caywood, Christiane Reitz, Gary W. Beecham, Goldie S. Byrd, Briseida E. Feliciano‐Astacio, William K. Scott, Jonathan L. Haines, Jeffery M. Vance, and Margaret A. Pericak‐Vance

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Published
2021

3. Identifying differential regulatory control of APOE ɛ4 on African versus European haplotypes as potential therapeutic targets

Author

Karen Nuytemans, Marina Lipkin Vasquez, Liyong Wang, Derek Van Booven, Antony J. Griswold, Farid Rajabli, Katrina Celis, Oded Oron, Natalia Hofmann, Sophie Rolati, Catherine Garcia‐Serje, Shanshan Zhang, Fulai Jin, Mariana Argenziano, Struan F.A. Grant, Alessandra Chesi, Christopher D. Brown, Juan I. Young, Derek M. Dykxhoorn, Margaret A. Pericak‐Vance, and Jeffery M. Vance

Subjects
Genotype, Epidemiology, Health Policy, Apolipoprotein E4, Black People, Polymorphism, Single Nucleotide, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Apolipoproteins E, Developmental Neuroscience, Haplotypes, Alzheimer Disease, Humans, Neurology (clinical), Geriatrics and Gerontology, Alleles
Abstract

We previously demonstrated that in Alzheimer's disease (AD) patients, European apolipoprotein E (APOE) ε4 carriers express significantly more APOE ε4 in their brains than African AD carriers. We examined single nucleotide polymorphisms near APOE with significant frequency differences between African and European/Japanese APOE ε4 haplotypes that could contribute to this difference in expression through regulation. Two enhancer massively parallel reporter assay (MPRA) approaches were performed, supplemented with single fragment reporter assays. We used Capture C analyses to support interactions with the APOE promoter. Introns within TOMM40 showed increased enhancer activity in the European/Japanese versus African haplotypes in astrocytes and microglia. This region overlaps with APOE promoter interactions as assessed by Capture C analysis. Single variant analyses pinpoints rs2075650/rs157581, and rs59007384 as functionally different on these haplotypes. Identification of the mechanisms for differential regulatory function for APOE expression between African and European/Japanese haplotypes could lead to therapeutic targets for APOE ε4 carriers.

Published
2021

4. Transcriptomic characterization of a Puerto Rican Alzheimer disease cohort implicates convergent immune‐related pathways

Author

Olivia K. Gardner, Pedro Ramon Mena, Farid Rajabli, Patrice L. Whitehead, Jeffery M. Vance, Vanessa C. Rodriguez, Nereida I. Feliciano, Gary W. Beecham, Kara L. Hamilton-Nelson, Jonathan L. Haines, Larry D. Adams, Catherine Garcia-Serje, Natalia K. Hofmann, Michael L. Cuccaro, Margaret A. Pericak-Vance, Concepcion Silva-Vergara, Heriberto Acosta, Anthony J. Griswold, and Briseida E. Feliciano-Astacio

Subjects
Genetics, Epidemiology, Health Policy, Systems biology, Puerto rican, Biology, medicine.disease, Omics, Transcriptome, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Immune system, Developmental Neuroscience, Cohort, medicine, Neurology (clinical), Geriatrics and Gerontology, Alzheimer's disease
Published
2020

5. [P3–169]: A PATIENT‐DERIVED IPSC MODEL OF A RARE TTC3 MUTATION

Author

Derek M. Dykxhoorn, Catherine Garcia‐Serje, Francelethia of Johnson, Regina Carney, Jeffery M. Vance, Michael L. Cuccaro, Margaret A. Pericak‐Vance, and Holly N. Cukier

Subjects
Genetics, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Mutation (genetic algorithm), Neurology (clinical), Geriatrics and Gerontology, Biology
Published
2017

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