Significant health disparities continue to persist across the cancer control continuum (prevention, detection, diagnosis, treatment, and survivorship) despite decreases in cancer mortality and morbidity rates. Public health informatics (PHI) approaches offer the potential to address and reduce cancer health disparities by addressing the underlying social determinants of health. Community engagement, through community-based participatory research (CBPR) in identification, development, evaluation, and implementation offers key advantages to enhanced sustainability, acceptability, and delivery of PHI. The CBPR approach allows community members and stakeholders to provide input from a culturally relevant perspective at each level of the development and/or use of PHIs. This chapter discusses the application of the CBPR approach to improve the use and adoption of informatics tools and platforms through two case study examples that are addressing two major social determinants of health disparities: institutional racism and information inequalities. Three common themes emerged from the two case studies that facilitated successful PHI project implementation: transparency, making data relevant, and capacity building. To ensure project success, the case studies also addressed challenges that may arise in PHIs such as digital health literacy, Internet and broadband accessibility, and PHI platform sustainability.