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OwnerOn Behalf of Ondokuz Mayis University Yavuz ÜNALDirector in ChargeCengiz ÇOKLUKSecretarial StaffIşınsu ALKAN Gamze ALTUN Burcu DELİBAŞ Erkan ERENER Elfide Gizem KIVRAK Adem KOCAMAN Ayşegül SAKALLIPublisher Administration OfficeOndokuz Mayıs University Faculty of Medicine Atakum / Samsun, TurkeyPublish TypePeriodicalOnline Published Date1 / 04 / 2021Scientific and legal responsibility of the papers that are published in the journal belong to the authors.Acid-free paper is used in this journal.Indexed: CEPIEC, Crossref, DOAJ, EMBASE, EBSCOhost, Google Scholar, Index Copernicus, J-Gate, NLM Catalog (PubMed), Research Gate, Turkiye Citation Index, World Cat.Cover ArtxxxxxxxEDITOR IN CHIEFCengiz ÇOKLUKASSOCIATED EDITORSYasemin ULUSSerkan YÜKSELDavut GÜVENMustafa ARASKıymet Kübra YURT LAYOUT EDITORSKıymet Kübra YURTAdem KOCAMANBurcu DELİBAŞErkan ERENERGamze YAYLAIşınsu ALKANSümeyye GÜMÜŞ UZUN

Intramedullary ependymomas are rare tumours but comprise the majority of intramedullary glial neoplasms in the adult. In this case report we introduced a 51 year old male patient with one month history of pain in the right arm and numbness in the right hand fingers. At neurological examination,there was a slight loss of sensory modalities along the right C6,C7,C8 dermatoms . Motor examination showed grade IV/V power in the right elbow flexion.Biceps and triceps tendon reflexes were diminished . In the sagittal Magnetic Resonance Images (MRI) there were a santrally localized mass lesion extending from C5 to T1 vertebra level and expanding the cord. There were also a milimetric syringomyelia cavity extending between T2-T4 vertebra .The tumour was removed totally . Pathological diagnosis was compatible with grade II ependymoma (World Health Organization Central Nervous System Tumour Classification 2007).No radiation therapy was advised to the patient. These tumours are benign, slow-growing lesions which are optimally treated with gross-total surgical resection without adjuvant therapy. Postoperative functional outcome is related to preoperative functional status. Hence, early diagnosis prior to symptomatic progressionis critical to the successful treatment of these tumours.

The aim of this experimental study was to evaluate the effect of omega-3 fatty acids solution in the prevention of the forming of peridural fibrotic tissue and adhesion in a rabbit hemilaminotomy model. This new experimental model was previously developed by the first author of this study. Twenty-one New Zealand white rabbits were used for this experiment. Seven of them were randomly selected as Control group and was named as Group I rabbits. The rabbits in this group were not operated and treated. The second group was Group II including 7 rabbits. This group was named as hemilaminotomy and untreated rabbits. Group III included 7 rabbits and named as Omega-3 treated group after hemilaminotomy procedure. In this group (Group III), 250 mg omega-3 solution was put in the hemilaminotomy area before closing the skin and fascia. Four weeks later from the operation rabbits were sacrificied by perfusion with 10% neutral buffered formalin solution. The lumbar spines were removed and immersed in 10% neutral buffered formalin for approximately 24 hours. Then each specimen was decalcified in 5% formic acid for approximately 3 weeks. Specimens were cut coronally for gross inspection. Peridural scar tissue on gross inspection in coronal sectioned specimens was graded into three grades. Grade I epidural scar tissue was scored with 1 point, Grade II with 2 point and Grade III with 3 point. The average score of hemilaminotomy sites without treatment was found as 2, 6 ± 0, 51. In the other hand the average score of hemilaminotomy sites with omega-3 fatty acids treatment was found as 1, 9 ± 0, 56. The difference between the treatment and non-treatment group was statistically significant. Omega-3 fatty acids solution seems an effective treatment modality in the prevention of peridural excessive scar tissue formation in the rabbit hemilaminotomy model.

The purpose of this study was to compare human fibrinogen-thrombin-based liquid dural graft; Beriplast® (Behring, Malburg, Germany) and collagen-based dural graft; Tissudura® (Baxter, Heidelberg, Germany) in terms of efficiency, side effects and complications. Thirty Spraque Dawley rats were used in this experimental study. A burrhole was opened on the left parietal bone of each subject and experimental dural defect was created. While 10 subjects were in sham group without any dural defect repair, dural defect was repaired by Beriplast in 10 subjects, by Tissudura in 10 subjects. After twenty-one day follow-up, edema, gliosis and inflammatory cell infiltration in the parenchyma, foreign body reaction in the bone, fibrosis in the epidural space and dura were evaluated histopathologically. Beriplast caused much more severe inflammation on cortex. When we compared Tissudura group with the sham group in terms of parenchymal edema and gliosis, the difference was not significant. On the other hand, we have found a significant increase in cortical parenchymal edema in Beriplast group. The last generation dural grafts result in different degrees of the tissue reaction. Severe inflammatory reaction can provide more satisfactory results in terms of watertight dural closure but on the other hand, the same reaction can be a disadvantage to the surrounding tissue.

Meme kanserinin en sık metastaz yaptığı yer kemiktir. Kemik metastazlarının da en sık yerleşim yeri vertebradır. Sıklıkla torakal ve lomber vertebralara metastaz yapar. Üst servikal metastazlar nadir görülürler fakat önemli nörolojik yapılara komşuluğu nedeniyle ölümcül komplikasyonlara yol açabilirler. Erken tanı ve tedavi hastanın sağkalım süresini ve yaşam kalitesini arttırması açısından önemlidir. Üst servikal metastazların nadir görülmesi ve ölümcül komplikasyonlara neden olabilmesi nedeniyle bu olgunun sunulması amaçlanmıştır.

Lomber disk hernisi, bel ağrısı ve radiküler ağrının yaygın bir nedenidir. Hastaların çoğu konservatif tedaviden fayda görür ve günlük yaşantısına dönebilir. Görüntüleme yöntemlerindeki gelişmeler ve kullanım sıklığının artması nedeniyle, herniye diskin gerilediği literatürde bildirilmiştir. Fakat hangi özellikteki disklerin ve ne kadar süre içerisinde gerilediği hakkında kesin elde edilmiş bulgular yoktur. Dört ay gibi bir sürede sekestre disk hernisinin regrese olması nedeniyle olgumuzu literatürler eşliğinde sunmayı uygun bulduk.

The primary treatment of malignant glial tumors is surgical intervention for maximally reducing and/or total removing of tumors. The purpose of this report was to describe pial sinangiosis or indirect nonanastomotic bypass surgery for diversion of blood brain barrier for enhancing of systemic blood-brain tissue penetration in the enhancing of the effect of chemotherapy. The other purposes are the increasing of oxygen and metabolic product providing, enhancing of radiation sensitivity, and stabilization of brain tissue around the tumor bed for reducing of malignant transformation. We used the technique of indirect non anastamotic by-pass surgery technique during the surgical treatment of malignant glial tumors. Preoperative and postoperative magnetic resonance images were obtained to evaluate peri-lesional edema and residual complications. This technique was used in three cases of malignant glial tumors. There were no operative mortality and morbidity related to this technique. This technique may be used during the surgical treatment of malignant glial tumors to enhance penetration of chemotherapeutic agents, increasing of radiation sensitivity and providing of tissue stability. Key Words: Pial synangiosis, indirect bypass surgery, malignant glial tumors, surgical treatment.