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This study is performed beneath In Vitro dissolution applying various mathematical approaches to observe the dissolution interference on simulated gastrointestinal digestion. In total, eight medicine samples wereollected in Bangladeshi market and the conventional approaches were followed to measure the result in gastric medium (pH 1.2). Altogether, the brands showed sensibly upper dissolution discharge; primarily P01 (98.9%), P08 (98.97%), P03 (98.32%) and P06 (98.24%) were released relatively faster than the other sample in 15 to 60 minutes. Along with the mango juice in the simulated gastric medium, the brands showed sensibly upper dissolution discharge; primarily P01 (98.83%), P07 (98.98%), P06 (98.78%) and P03 (98.38%) were released relatively faster than the other sample in 15 to 60 minutes. This result depicts to understand the proper release of kinetics with the help of various mathematical model such as Zero order, First order, Higuchi and Hixson-Crowell model etc. although Paracetamol can interact with the fruit juices, which may alter the drug release, drug absorption in the body and may also lead to an unwanted reaction.

The aim of this present work is to investigate the antimicrobial, antioxidant and cytotoxic activities of methanol extract of Polygonum orientale (Family: Polygonaceae). Antimicrobial activity of methanol extract of Polygonum orientale was tested by Disc Diffusion Method. Standard antibiotic discs of Kanamycin (30µg/disc) for bacterial species was used as standard and crude extracts were used at a concentration of (20mg/disc) and (40mg/disc) for leaves and (10mg/disc) and (20mg/disc) for shoot extracts. The methanol extracts of leaves and shoots showed mild activity against gram positive bacteria, gram negative bacteria and fungi. Most of the organisms were susceptible to the extract in various degrees. The extract showed highest zone of inhibition (13mm) against the Gram (+)ve Bacillus megaterium and and gram (-)ve Escherichia coli (zone of inhibition 10mm). Antioxidant property of the plant extracts against stable DPPH (1, 1-Dipheny1-2-picrydrazole) radical was investigated. Ascorbic acid was used as standard. The extract was found low in antioxidant property. The absorbance was taken at 517nm by UV Spectrophotometer. The IC 50 values were found in leaf extract and shoot extract are (1244.58µg/ml and (1506µg/ml). For ascorbic acid IC 50 value was (139.19µg/ml). Cytotoxic activity of the crude extract by using Brine Shrimp Lethality Bioassay. Vincristin sulphate was used as standard. LC 50 value of leaf extract was found (6.85µg/ml) and (9.7104µg/ml) for the shoot extract. In conclusion, the extract of the experimental plants have mild antimicrobial, low antioxidant and good cytotoxic properties.