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13 results on '"Zidovudine -- Complications and side effects"'

1. Human immunodeficiency virus treatment-induced adipose tissue pathology and lipoatrophy: prevalence and metabolic consequences

Author

Hammond, Emma, McKinnon, Elizabeth, and Nolan, David

Subjects
Lipodystrophy -- Development and progression, Lipodystrophy -- Distribution, Lipodystrophy -- Complications and side effects, Lipodystrophy -- Research, HIV infection -- Care and treatment, HIV infection -- Complications and side effects, HIV infection -- Patient outcomes, HIV infection -- Research, Metabolic diseases -- Development and progression, Metabolic diseases -- Patient outcomes, Metabolic diseases -- Research, Stavudine -- Complications and side effects, Stavudine -- Research, Zidovudine -- Complications and side effects, Zidovudine -- Research, Company distribution practices, Health, Health care industry
Published
2010

2. Abacavir/lamivudine/zidovudine maintenance after standard induction in antiretroviral therapy-naive patients: free randomized trial interim results

Author

Sprenger, Herman G., Langebeek, Nienke, Mulder, Paul G.H., Napel, Chris H.H. Ten, Vriesendorp, Robert, Hoepelman, Andy I.M., Legrand, Jean-Claude, Koopmans, Peter P., Van Kasteren, Marjo E.E., Bravenboer, Bert, Kate, Reinier W. Ten, Groeneveld, Paul H.P., van der Werf, Tjip S., Gisolf, Elisabeth H., and Richter, Clemens

Subjects
Abacavir -- Dosage and administration, Abacavir -- Complications and side effects, Lamivudine -- Dosage and administration, Lamivudine -- Complications and side effects, Zidovudine -- Dosage and administration, Zidovudine -- Complications and side effects, HIV infection -- Drug therapy, Health
Abstract

Maintenance with a triple nucleoside reverse transcriptase Inhibitor (NRTI) regimen after successful induction with a dual NRTI/protease inhibitor (PI) combination may be advantageous, because of low pill burden, favorable lipids, and less drug interactions. This strategy to become free of PI-related problems without losing viral efficacy has not been formally tested. We performed a randomized, open-label, multicenter, 96-week comparative study in antiretroviral therapy (ART)-naive patients with CD4 50 copies per milliliter). Two hundred seven patients had similar baseline (BL) char- acteristics: median CD4 180 cells/[mm.sup.3], median VL 5.19 log10 copies per milliliter. One hundred twenty subjects (58%) met randomization criteria. Baseline VL differed significantly between dropouts and randomized subjects (median 5.41 versus 5.06 log10 copies per milliliter, p = 0.017), as did CD4 cells (median 160 and 200 cells/ram3, p = 0.044). Sixty-one subjects received TZV and 59 subjects continued NRTIs/PI. At week 48, 2 patients in the TZV group and 5 in the PI group did not have a sustained virologic suppression (log rank test; p = 0.379). CD4 counts increased significantly in both arms. In ART-naive patients, TZV maintenance had similar antiviral efficacy compared to continued standard ART at 48 weeks after baseline. Patients on successful standard ART can be safely switched to a NRTI-only regimen, at least for the tested time period. DOI: 10.1089/apc.2009.0236

Published
2010

3. Epidemiological and biological evidence for a compensatory effect of connection domain mutation N348I on M184V in HIV-1 reverse transcriptase

Author

von Wyl, VIktor, Ehteshami, Maryam, Symons, Jori, Burgisser, Philippe, Nijhuis, Monique, Demeter, Lisa M., Yerly, Sabine, Boni, Jurg, Klimkait, Thomas, Schuurman, Rob, Ledergerber, Bruno, Gotte, Matthias, and Gunthard, Huldrych F.

Subjects
Gene mutations -- Research, Reverse transcriptase -- Genetic aspects, Reverse transcriptase -- Research, HIV infection -- Genetic aspects, HIV infection -- Research, Zidovudine -- Dosage and administration, Zidovudine -- Complications and side effects, Lamivudine -- Dosage and administration, Lamivudine -- Complications and side effects, Drug resistance in microorganisms -- Genetic aspects, Drug resistance in microorganisms -- Research, Health
Published
2010

4. Lactic acidosis in HIV infected patients: a systematic review of published cases

Author

Arenas-Pinto, A, Grant, AD, Edwards, S, and Weller, IVD

Subjects
Zidovudine -- Complications and side effects, HIV patients -- Physiological aspects -- Chemical properties, Lactic acidosis -- Risk factors -- Complications and side effects, Health
Abstract

Objective: To describe the clinical, epidemiological, and biochemical characteristics of published cases of lactic acidosis (LA) and to generate hypotheses concerning risk factors associated with this complication. Methods: Systematic review [...]

Published
2003

5. Risk of death or HIV infection similar for two infant feeding regimens

Author

London, S.

Subjects
Zidovudine -- Complications and side effects, Infants -- Health aspects, HIV infection -- Health aspects -- Risk factors -- Complications and side effects, Family and marriage, Health, Complications and side effects, Risk factors, Health aspects
Abstract

Among babies born to HIV-infected mothers, those who are fed breast milk and given zidovudine for the first six months of life have a risk of dying or contracting HIV [...]

Published
2006

7. HIV & Pregnancy. (Shorts)

Author

Klotter, Jule

Subjects
Infants -- Patient outcomes, Pregnancy, Mortality -- United States, Zidovudine -- Complications and side effects, HIV infection in children -- Prevention -- Patient outcomes -- Complications and side effects, HIV infection -- Patient outcomes -- Complications and side effects -- Prevention, Health
Abstract

The US Public Health Service policy for treating HIV-positive, pregnant women includes anti-HIV drugs during pregnancy and intravenous AZT (azidothymidine, aka zidovudine or Retrovir) during labor. Their newborns are given [...]

Published
2002

8. Abstract & commentary: thinner: trying to solve the lipoatrophy puzzle

Author

Winslow, Dean L.

Subjects
Stavudine -- Reports, Stavudine -- Dosage and administration, Stavudine -- Complications and side effects, Zidovudine -- Dosage and administration, Zidovudine -- Complications and side effects, Zidovudine -- Reports, Lipodystrophy -- Development and progression, AIDS treatment -- Complications and side effects, AIDS treatment -- Patient outcomes, Health
Abstract

Thinner: Trying to solve the lipoatrophy puzzle 'A visual reminder of HIV-positive status' By Dean L. Winslow, MD, FACP, FIDSA, Chief, Division of AIDS Medicine, Santa Clara Valley, Medical Center; [...]

Published
2010

9. Mitochondrial Disease Can be Byproduct of Zidovudine During Pregnancy

Subjects
Pregnancy, Birth defects -- Risk factors -- Complications and side effects, Zidovudine -- Complications and side effects, HIV infection in pregnancy, HIV infection -- Risk factors -- Complications and side effects, Health
Abstract

2000 AUG 1 - (NewsRx.com) -- Zidovudine (ZDV) treatment during pregnancy of HIV infected women may damage fetal mitochondria, researchers in Italy reported. 'Mitochondrial disease is a possible side effect [...]

Published
2000

10. AZT, d4T Ok'd for infants

Subjects
HIV infection -- Drug therapy, Stavudine -- Dosage and administration, Stavudine -- Complications and side effects, Zidovudine -- Dosage and administration, Zidovudine -- Complications and side effects, Health
Abstract

AZT, d4T OKEd for infants At the same time a blue-ribbon panel found that the benefits of zidovudine (AZT) therapy for HIV-positive pregnant women and their babies outweigh the risk, [...]

Published
1997

11. Maternal AZT linked to cancer in mouse, monkey studies

Author

DeNoon, Daniel J.

Subjects
Zidovudine -- Complications and side effects, Cancer -- Risk factors -- Complications and side effects, Health, Complications and side effects, Risk factors
Abstract

Maternal use of zidovudine (AZT) during pregnancy protects children against HIV transmission but may cause cancer later in life, animal studies suggest. A National Institutes of Health (NIH) panel concluded [...]

Published
1997

12. Methadone interacts with common HIV drug

Subjects
Zidovudine -- Complications and side effects, HIV patients, Methadone hydrochloride -- Complications and side effects, Government, Health, Psychology and mental health
Abstract

HIV-positive patients who are simultaneously receiving treatment with methadone and the AIDS drug zidovudine may be at risk of exposure to high levels of zidovudine and subsequent side effects, according [...]

Published
1998

13. Effect of treatment with zidovudine on subsequent incidence of Kaposi's sarcoma

Author

Joffe, M.M., Hoover, D.R., Jacobson, L.P., Kingsley, L., Chmiel, J.S., and Visscher, B.R.

Subjects
Kaposi's sarcoma -- Risk factors -- Complications and side effects, Zidovudine -- Complications and side effects, AIDS (Disease) -- Complications and side effects -- Risk factors, Health, Complications and side effects, Risk factors
Abstract

According to the authors' abstract of an article published in Clinical Infec- tious Diseases, 'Despite much investigation of zidovudine, little has been reported regarding its effect on the development of [...]

Published
1998

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