1. Calorie restriction enhances T-cell--mediated immune response in adult overweight men and women
- Author
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Ahmed, Tanvir, Das, Sai Krupa, Golden, Julie K., Saltzman, Edward, Roberts, Susan B., and Meydani, Simin Nikbin
- Subjects
Aging -- Health aspects ,Low-calorie diet -- Health aspects ,Overweight persons -- Food and nutrition ,Overweight persons -- Health aspects ,T cells -- Research ,Health ,Seniors - Abstract
Calorie restriction (CR) enhances immune response and prolongs life span in animals. However, information on the applicability of these results to humans is limited. T-cell function declines with age. We examined effects of CR on T-cell function in humans. Forty-six overweight, nonobese participants aged 20-42 years were randomly assigned to 30% or 10% CR group for 6 months. Delayed-type hypersensitivity (DTH), T-cell proliferation (TP), and prostaglandin [E.sub.2] ([PGE.sub.2]) productions were determined before and after CR. DTH and TP to T-cell mitogens were increased in both groups over baseline (p [less than or equal to] .019). However, number of positive responses to DTH antigens (p = .016) and TP to anti-CD3 reached statistical significance only alter 30% CR (p = .001). Lipopolysaccharide-stimulated [PGE.sub.2] was reduced in both groups but reached statistical significance after 30% CR (p [less than or equal to] .029). These results, for the first time, show that 6-month CR in humans improves T-cell function. Key Words: Calorie restriction--T cell--Immune response--Aging--Obesity. doi: 10.1093/gerona/glp101
- Published
- 2009