Fluoride agents are effective in reducing tooth decay and have been assessed recently for their value in treating periodontal disease, which affects the structures supporting the teeth, such as the gums. Sodium fluoride (NaF) was shown to reduce bacterial growth in plaque, which is a gummy mass of microorganisms growing on the surface of teeth. However, several studies suggest that stannous fluoride (SnF2) may be more effective than NaF in reducing the bacteria in plaque. The effects of brushing with 0.4 percent SnF2 or 0.22 percent NaF on gingivitis, the inflammation of the gums, was evaluated in 281 subjects with the gum disease. The subjects, who were divided into three groups, were instructed to brush with a fluoride-containing toothpaste accepted by the American Dental Association, to rinse with water, and subsequently to brush with either 0.4 percent SnF2, 0.22 percent NaF, or a fluoride-free placebo gel, a substance with no known therapeutic effect. The subjects who brushed with SnF2 had more tooth staining than subjects in the other two groups. There were no differences among the three groups in gingivitis, bleeding, or amounts of various microorganisms when subjects were examined at 6, 12 and 18 months. The findings suggest that NaF and SnF2 have no ability to reduce gingivitis. (Consumer Summary produced by Reliance Medical Information, Inc.)