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Study objective: To investigate the efficacy and safety of a fully human monoclonal antibody recognizing the chemokine interleukin (IL)-8 in patients with COPD. Design: Randomized, double-blind, parallel-group, placebo-controlled trial. Setting: [...]

Study objectives: The objectives of this study were as follows: (1) to compare results of the discrete and the continuous methods for measuring breathlessness; (2) to examine test-retest reliability; (3) [...]

There has been a resurgence of interest in pulmonary rehabilitation mainly because the prevalence of COPD has increased, scientific studies document consistent benefits (increased exercise endurance and reduced dyspnea), and [...]

Study objective: To investigate the ability of patients with COPD to reproduce an exercise intensity accurately on the treadmill using dyspnea ratings obtained during incremental exercise on the cycle ergometer [...]

Study objective: To investigate the short-term effects of inhaled salmeterol on the perception of dyspnea and lung function in patients with COPD Design: Double-blind, crossover, randomized trial comparing inhaled salmeterol [...]

Study objective: We tested the hypothesis that patients with COPD can use dyspnea ratings obtained from a prior graded exercise test as a target to reliably produce specific exercise intensities. [...]

Study objective: To evaluate the short-form 36-item questionnaire (SF-36) as an instrument for measuring health-related quality of life (HRQL) in patients with symptomatic COPD. Design: Observational data at a single [...]

Study Objective: To examine the relationships among clinical dyspnea ratings, physiologic pulmonary function, and general health status in symptomatic patients with chronic obstructive pulmonary disease (COPD). Design: Observational data collected [...]

The responsiveness of a new computerized method for patients to provide continuous ratings of dyspnea during exercise in patients with chronic obstructive pulmonary disease (COPD) is examined. Results reveal that continuous ratings of dyspnea were responsive to inhaled bronchodilator therapy during both incremental and constant work exercise tests in patients with symptomatic COPD.

Research indicates that patients with chronic obstructive pulmonary disease can use the same dyspnea ratings after their participation in pulmonary rehabilitation to monitor exercise training at the same relative intensity regardless of the physiologic response.

Background: Patients with COPD often require multiple therapies to improve lung function and decrease symptoms and exacerbations. Salmeterol and theophylline are indicated for the treatment of COPD, but the use [...]

Richard Casaburi, PhD, MD(*); Donald A Mahler, MD; Paul W Jones, PhD; Charles W Serby, MD; Shailendra S Menjoge, PhD and Theodore J Witek, Dr, PH. Division of Respiratory Medicine, [...]

Study objectives: We tested the hypothesis that descriptors of breathlessness represent distinct and separable cognitive constructs, and predicted that the use of descriptors of breathlessness by healthy individuals is the [...]

The traditional approach of caring for patients with chronic respiratory disease has been to rely on pulmonary function tests to quantify the severity and to assess response to therapy. However, [...]

Flaws and Guffaws To the Editor: A recent article by Mahler et al (April 1999)[1] that compared the effectiveness of a highly potent inhaled Β-agonist with an established and effective [...]

To the Editor: When we read the article in CHEST (September 2004) (1) by Mahler et al, we may think that placebo-controlled trials are difficult to perform. The overall results [...]

[Editor's note: Dyspnea is an extremely common symptom in patients with respiratory or cardiac disorders. Over the years, advances have been made in quantifying this symptom. Dr Mahler has been [...]

Training of patients with moderate to severe chronic obstructive pulmonary disease to strengthen their respiratory muscles was shown to improve the functional capacity of the respiratory muscles and to reduce dyspnea, or breathlessness. a study was conducted in which 19 patients trained for 15 minutes, twice a day with a device which provided resistance when the patients breathed in. The device provided feedback to the patients, as it showed how strong each breath was, which allowed the patients to tell if they were training properly on a breath-to-breath basis. Patients who were in a control group trained at a constantly low resistance level, while those in an experimental group trained at increased levels of resistance. The patients who trained at increased levels of resistance showed a significant increase in the strength of their inspiratory muscles. There was, however, no significant increase in the maximum inspiratory pressure that could be achieved in the trained group compared with the control group. The trained patients had decreased dyspnea after eight weeks of training. There was no change in either lung function or strength of the expiratory muscles of the patients after training. Therefore, patients with chronic obstructive pulmonary disease may have reduced dyspnea, if they strengthen their respiratory muscles through a training program. Further study is needed to determine the optimum conditions of the training, such as the frequency, duration and intensity. (Consumer Summary produced by Reliance Medical Information, Inc.)

To evaluate measurements of respiratory sensation in ILD, we compared ratings of breathlessness from three clinical scales with the perceived magnitude of added elastic loads in 20 symptomatic ILD patients. [...]

(Chest 1992; 102:1875-76) A 65-year-old woman was referred because of a 2-month history of progressive dyspnea on exertion, a 5.5-kg weight loss, and muscle weakness. She had stopped doing her [...]

PURPOSE: To examine and compare the component and total scores of the self-administered computerized (SAC) versions of the Baseline (BDI) and the Transition (TDI) Dyspnea Indexes with scores from the [...]

Study objectives: To examine and compare the efficacy and safety of salmeterol xinafoate, a long-acting inhaled [Β.sub.2]-adrenergic agonist, with inhaled ipratropium bromide and inhaled placebo in patients with COPD. Design: [...]