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12 results on '"Levis, William"'

1. TH17 is involved in the remarkable regression of metastatic malignant melanoma to topical diphencyprone

Author

Martiniuk, Frank, Damian, Diona L., Thompson, John F., Scolyer, Richard A., Tchou-Wong, Kam-Meng, and Levis, William R.

Subjects
Melanoma -- Development and progression, Melanoma -- Drug therapy, Gene expression -- Research, Biological response modifiers -- Product development, Biological response modifiers -- Dosage and administration, Health, Pharmaceuticals and cosmetics industries
Abstract

ABSTRACT The authors provide an update on a previously reported patient with in-transit metastatic melanoma of the scalp treated with topical diphencyprone (DPCP). Molecular studies implicate the thymus-derived TH17 lymphocyte [...]

Published
2010

2. Thalidomide and analogues: potential for immunomodulation of inflammatory and neoplastic dermatologic disorders

Author

Ladizinski, Barry, Shannon, Edward J., Sanchez, Miguel R., and Levis, William R.

Subjects
Thalidomide -- Usage, Thalidomide -- Properties, Skin diseases -- Care and treatment, Health, Pharmaceuticals and cosmetics industries
Abstract

ABSTRACT Thalidomide and analogues are a class of immunomodulatory drugs or IMiDS. Thalidomide was initially approved by the U.S. Food and Drug Administation for treatment of erythema nodosum in leprosy [...]

Published
2010

3. Effect of thalidomide on nitric oxide production in lipopolysaccharide-activated RAW 264.7 cells

Author

Park, Eunkyue, Levis, William R., Greig, Nigel, Jung, Euisun, and Schuller-Levis, Georgia

Subjects
Inflammation -- Drug therapy, Inflammation -- Prognosis, Nitric oxide -- Physiological aspects, Nitric oxide -- Genetic aspects, Thalidomide -- Dosage and administration, Thalidomide -- Complications and side effects, Tumor necrosis factor -- Health aspects, Tumor necrosis factor -- Genetic aspects, Health, Pharmaceuticals and cosmetics industries
Abstract

ABSTRACT Thalidomide is anti-inflammatory under some conditions, yet has been reported to up-regulate Th1 (T helper 1) immunity measured by increased IL-2 (Interleukin-2) and gamma interferon. The authors have assessed [...]

Published
2010

4. Expression of CD70 and the TH17 transcription factor ROR[gamma]T in human contact dermatitis

Author

Martiniuk, Frank, Lee, David S., Gaspari, Anthony, Yee, Herman, Chiriboga, Luis, Huie, Maryann, Tchou-Wong, Kam-Meng, and Levis, William R.

Subjects
Contact dermatitis -- Care and treatment, Contact dermatitis -- Genetic aspects, Contact dermatitis -- Research, DNA binding proteins -- Physiological aspects, DNA binding proteins -- Research, Gene expression -- Research, Immunotherapy -- Health aspects, Immunotherapy -- Research, Health, Pharmaceuticals and cosmetics industries
Abstract

ABSTRACT Contact sensitizers are a major cause of inflammatory skin disease and as topical immunomodulators also have the potential for treating cancer, viral diseases and certain autoimmune disorders. In the [...]

Published
2008

5. Heat-shock proteins as drugs: potential applications in cancer, infections, and autoimmune and atopic diseases

Author

Holzer, Aton M., Martiniuk, Frank, and Levis, William R.

Subjects
Heat shock proteins -- Usage, Heat shock proteins -- Health aspects, Autoimmune diseases -- Drug therapy, Skin diseases -- Drug therapy, Health, Pharmaceuticals and cosmetics industries
Abstract

Abstract Heat-shock proteins (HSPs) serve as both a valuable target as well as a potent tool in the therapy of melanoma and human papillomavirus infections. HSPs have been found to [...]

Published
2007

6. Identification of novel hsp65 RFLPs for Mycobacterium leprae

Author

Martiniuk, Frank, Tambini, Marc, Rahimian, Joseph, Moreira, Andre, Yee, Herman, Tchou-Wong, Kam-Meng, Hanna, Bruce A., Rom, William N., and Levis, William R.

Subjects
Leprosy -- Causes of, Leprosy -- Diagnosis, Leprosy -- Development and progression, Leprosy -- Care and treatment, Mycobacterium leprae -- Causes of, Mycobacterium leprae -- Complications and side effects, Mycobacterium leprae -- Diagnosis, Mycobacterium leprae -- Analysis, Health, Pharmaceuticals and cosmetics industries
Abstract

Abstract Leprosy or Hansen's disease is a chronic infectious disease caused by an acid-fast bacillus, Mycobacterium leprae (M. leprae). The bacilli proliferate in macrophages infiltrating the skin and gain entry [...]

Published
2007

7. Topical diphenylcyclopropenone as a measure of immune competence in HIV-seropositive subjects

Author

Levis, William R., Holzer, Aton M., and Kaplan, Leonard L.

Subjects
Health, Pharmaceuticals and cosmetics industries
Abstract

Abstract Background: CD4 T cell counts are recognized as the standard method for monitoring HIV-seropositive patients and, along with viral load, are clinically important as indicators for initiating highly active [...]

Published
2006

8. Haptens as drugs: contact allergens are powerful topical immunomodulators

Author

Holzer, Aton M., Kaplan, Leonard L., and Levis, William R.

Subjects
Asthma, Health, Pharmaceuticals and cosmetics industries
Abstract

Abstract For the past 40 years, dermatologists have safely used contact sensitizers such as dinitrochlorobenzene (DNCB), diphenylcyclopropenone (DPCP), and squaric acid dibutylester (SADBE) for the treatment of warts, alopecia areata, [...]

Published
2006

9. The role of complement in dendritic cell (DC) control of T-cell subsets

Author

Levis, William R. and Martiniuk, Frank

Subjects
Dendritic cells -- Health aspects, Dendritic cells -- Research, Immunotherapy -- Health aspects, Melanoma -- Genetic aspects, Melanoma -- Care and treatment, Melanoma -- Research, Health, Pharmaceuticals and cosmetics industries
Abstract

ABSTRACT This section of the Journal of Drugs in Dermatology (JDD) is dedicated to Dendreon's Provenge (Sipuleucel-T), the first therapeutic DC vaccine proven effective and approved by the United States [...]

Published
2010

10. Molecular origin of endemic leprosy in New York City

Author

Keo, Thormika, Martiniuk, Frank, Latkowski, JoAnn, Cabrera, Aloys, Rom, William, and Levis, William R.

Subjects
Leprosy -- Case studies, Leprosy -- Genetic aspects, Health, Health care industry
Published
2008

11. HIV and leprosy in the eastern United States

Author

Lu, Phoebe D., Patel, Manisha J., Yosipovitch, Gil, Martiniuk, Frank, Cabrera, Aloys, and Levis, William R.

Subjects
United States -- Health aspects, HIV infection -- Risk factors, HIV infection -- Care and treatment, Leprosy -- Care and treatment, Leprosy -- Risk factors, Health
Published
2005

12. Letter to the editor

Author

Levis, William R., Spencer, Trudy I., and Ladizinski, Barry

Subjects
Health, Pharmaceuticals and cosmetics industries
Abstract

Minocycline is Effective and Cosmetically Preferred to Clofazimine by Leprosy Patients in New York When Novartis discontinued distribution of Lamprene[R] (clofazimine) in 2004, the drug became unavailable in the United [...]

Published
2010

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