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We conducted a randomized double-blind placebo-controlled study evaluating the influence of 5 weeks' duration of 30 g enteral glutamine supplementation on inflammatory and hormonal responses in 73 patients with rectal cancer undergoing preoperative radiochemotherapy. Plasma levels of inflammatory and hormonal parameters were controlled at the beginning and at the end of supplementation. Enteral glutamine resulted in modulation of inflammatory and hormonal responses as shown by a decreased plasma interleukin 6 and cortisol levels in glutamine compared with placebo group: 5.5[plus or minus]3.8 versus 11.1[plus or minus]19.9 ng/l (P=0.02) for IL-6 and 386[plus or minus]168.4 to 312.7[plus or minus]111.7 nmol/l (P=0.03) for cortisol. We conclude that enteral glutamine exhibits some anti-inflammatory activity and, consequently, leads to a lower hormonal stress response during radiochemotherapy in patients with rectal cancer., Author(s): N Rotovnik Kozjek [sup.1] , L Kompan [sup.1] , T Zagar [sup.1] , Z Mrevlje [sup.2] Author Affiliations: (1) Institute of Oncology, Zaloska 2, LjubljanaLjubljana, Slovenia (2) Department of [...]

We conducted a randomized double-blind placebo-controlled study evaluating the influence of 5 weeks%apos; duration of 30 g enteral glutamine supplementation on inflammatory and hormonal responses in 73 patients with rectal cancer undergoing preoperative radiochemotherapy. Plasma levels of inflammatory and hormonal parameters were controlled at the beginning and at the end of supplementation. Enteral glutamine resulted in modulation of inflammatory and hormonal responses as shown by a decreased plasma interleukin 6 and cortisol levels in glutamine compared with placebo group: 5.5[+ or -]3.8 versus 11.1[+ or -]19.9 ng/l (P=0.02) for IL-6 and 386[+ or -]168.4 to 312.7[+ or -]111.7 nmol/l (P=0.03) for cortisol. We conclude that enteral glutamine exhibits some anti-inflammatory activity and, consequently, leads to a lower hormonal stress response during radiochemotherapy in patients with rectal cancer. European Journal of Clinical Nutrition (2017) 71, 671-673; doi: 10.1038/ejcn.2017.11; published online 8 March 2017, Author(s): N Rotovnik Kozjek [1]; L Kompan [1]; T [Z caron]agar [1]; [Z caron] Mrevlje [2] Introduction Colorectal cancer is the third most common cancer in the world. When locally [...]