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Purpose of Review: The purpose of this manuscript is to illuminate the diagnostic challenges in patients who present with both headache and neck pain., Recent Findings: The differential diagnosis for headache and neck pain includes many conditions. Furthermore, cervical musculoskeletal abnormalities including head forward posture and myofascial trigger points may play an overlapping role in many of these conditions. Multiple headache disorders may be present within the same patient. A multidisciplinary team approach addressing all components of the headache may lead to better outcomes for these patients.