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Your search keyword '"Komarck, Christine M."' showing total 3 results
Start Over Author "Komarck, Christine M." Topic head and neck neoplasms
3 results on '"Komarck, Christine M."'

1. Prognostic biomarkers in patients with human immunodeficiency virus-positive disease with head and neck squamous cell carcinoma.

Author

Zhang H, Kim S, Chen Z, Nannapaneni S, Chen AY, Moore CE, Sica G, Mosunjac M, Nguyen MLT, D'Souza G, Carey TE, Peterson LA, McHugh JB, Graham M, Komarck CM, Wolf GT, Walline HM, Bellile E, Riddell J 4th, Pai SI, Sidransky D, Westra WH, William WN Jr, Lee JJ, El-Naggar AK, Ferris RL, Seethala R, Grandis JR, Chen ZG, Saba NF, and Shin DM

Subjects
Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell mortality, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell therapy, Case-Control Studies, Cause of Death, Combined Modality Therapy, Disease-Free Survival, Female, HIV Infections diagnosis, HIV Infections epidemiology, HIV Seropositivity epidemiology, Head and Neck Neoplasms pathology, Head and Neck Neoplasms therapy, Humans, Kaplan-Meier Estimate, Logistic Models, Male, Middle Aged, Multivariate Analysis, Prognosis, Proportional Hazards Models, Retrospective Studies, Risk Assessment, Squamous Cell Carcinoma of Head and Neck, Survival Analysis, Treatment Outcome, Biomarkers, Tumor metabolism, Carcinoma, Squamous Cell virology, HIV Seropositivity pathology, Head and Neck Neoplasms mortality, Head and Neck Neoplasms virology, Transforming Growth Factor beta1 metabolism
Abstract

Background: We examined the prognostic value of a panel of biomarkers in patients with squamous cell carcinoma of the head and neck (SCCHN) who were human immunodeficiency virus (HIV) positive (HIV-positive head and neck cancer) and HIV negative (HIV-negative head and neck cancer)., Methods: Tissue microarrays (TMAs) were constructed using tumors from 41 disease site-matched and age-matched HIV-positive head and neck cancer cases and 44 HIV-negative head and neck cancer controls. Expression of tumor biomarkers was assessed by immunohistochemistry (IHC) and correlations examined with clinical variables., Results: Expression levels of the studied oncogenic and inflammatory tumor biomarkers were not differentially regulated by HIV status. Among patients with HIV-positive head and neck cancer, laryngeal disease site (P = .003) and Clavien-Dindo classification IV (CD4) counts <200 cells/μL (P = .01) were associated with poor prognosis. Multivariate analysis showed that p16 positivity was associated with improved overall survival (OS; P < .001) whereas increased expression of transforming growth factor-beta (TGF-β) was associated with poor clinical outcome (P = .001)., Conclusion: Disease site has significant effect on the expression of biomarkers. Expression of tumor TGF-β could be a valuable addition to the conventional risk stratification equation for improving head and neck cancer disease management strategies., (© 2017 Wiley Periodicals, Inc.)

Published
2017
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2. In vivo Wnt pathway inhibition of human squamous cell carcinoma growth and metastasis in the chick chorioallantoic model.

Author

Rudy SF, Brenner JC, Harris JL, Liu J, Che J, Scott MV, Owen JH, Komarck CM, Graham MP, Bellile EL, Bradford CR, Prince ME, and Carey TE

Subjects
Animals, Carcinoma, Squamous Cell metabolism, Carcinoma, Squamous Cell secondary, Cell Line, Tumor, Chick Embryo, Chorioallantoic Membrane pathology, DNA Mutational Analysis, Head and Neck Neoplasms metabolism, Head and Neck Neoplasms secondary, Humans, Mice, Neoplasm Metastasis, Polymerase Chain Reaction, Receptor, Notch1 metabolism, Squamous Cell Carcinoma of Head and Neck, Wnt Proteins metabolism, Wnt Signaling Pathway, Carcinoma, Squamous Cell genetics, Chorioallantoic Membrane metabolism, DNA genetics, Head and Neck Neoplasms genetics, Mutation, Neoplasms, Experimental, Receptor, Notch1 genetics, Wnt Proteins genetics
Abstract

Background: Head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer with poor overall survival. New therapeutic strategies that target specific molecular lesions driving advanced disease are needed. Herein we demonstrate the utility of the chicken chorioallantoic membrane (CAM) assay for in vivo human HNSCC tumor growth and metastasis and the tumor suppressive effects of a new chemotherapeutic agent., Methods: We tested anti-metastatic effects of a WNT pathway inhibitor, WNT974 (also known as LGK974), which targets porcupine (PORCN) the palmityl-transferase that is essential for secretion of Wnt proteins. CAM assays were performed with 8 HNSCC cell lines: UM-SCC-1, UM-SCC-10A, UM-SCC-10B, UM-SCC-11A, UM-SCC-14A UM-SCC-17A, UM-SCC-17B, UM-SCC-25, and UM-SCC-34., Results: UM-SCC-1 (University of Michigan Squamous Cell Carcinoma cell line) CAM xenografts contain CD44+ and ALDH+ cancer stem cell (CSC) proportions similar to UM-SCC-1 mouse xenografts supporting the applicability of the CAM assay for study of CSCs. Inhibition of WNT signaling by the PORCN inhibitor WNT974 reduced metastatic spread of UM-SCC cells, especially in UM-SCCs with Notch1 deficiency., Conclusions: Our data demonstrate decreased tumor growth and metastases in tumors from cell lines that showed in vitro responses to WNT974, providing evidence that this agent may have a role in future HNSCC therapy.

Published
2016
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3. Prognostic biomarkers in patients with human immunodeficiency virus-positive disease with head and neck squamous cell carcinoma

Author

Zhang, Hongzheng, Kim, Sungjin, Chen, Zhengjia, Nannapaneni, Sreenivas, Chen, Amy Y, Moore, Charles E, Sica, Gabriel, Mosunjac, Marina, Nguyen, Minh Ly T, D'Souza, Gypsyamber, Carey, Thomas E, Peterson, Lisa A, McHugh, Jonathan B, Graham, Martin, Komarck, Christine M, Wolf, Gregory T, Walline, Heather M, Bellile, Emily, Riddell, James, Pai, Sara I, Sidransky, David, Westra, William H, William, William N, Lee, J Jack, El-Naggar, Adel K, Ferris, Robert L, Seethala, Raja, Grandis, Jennifer R, Chen, Zhuo Georgia, Saba, Nabil F, Shin, Dong M, and Head and Neck Cancer SPORE HIV supplement consortium

Subjects
Adult, Male, Clinical Sciences, HIV Infections, Kaplan-Meier Estimate, Risk Assessment, survival, Disease-Free Survival, Transforming Growth Factor beta1, Rare Diseases, Clinical Research, Cause of Death, HIV Seropositivity, 80 and over, Humans, 2.1 Biological and endogenous factors, Dental/Oral and Craniofacial Disease, Aetiology, Proportional Hazards Models, Retrospective Studies, Aged, Cancer, Tumor, human immunodeficiency virus, Squamous Cell Carcinoma of Head and Neck, Prevention, Carcinoma, biomarkers, Middle Aged, Prognosis, Combined Modality Therapy, Survival Analysis, Treatment Outcome, Logistic Models, Good Health and Well Being, Squamous Cell, Otorhinolaryngology, Head and Neck Neoplasms, Case-Control Studies, Dentistry, Multivariate Analysis, HIV/AIDS, Head and Neck Cancer SPORE HIV supplement consortium, Female, head and neck cancer
Abstract

BackgroundWe examined the prognostic value of a panel of biomarkers in patients with squamous cell carcinoma of the head and neck (SCCHN) who were human immunodeficiency virus (HIV) positive (HIV-positive head and neck cancer) and HIV negative (HIV-negative head and neck cancer).MethodsTissue microarrays (TMAs) were constructed using tumors from 41 disease site-matched and age-matched HIV-positive head and neck cancer cases and 44 HIV-negative head and neck cancer controls. Expression of tumor biomarkers was assessed by immunohistochemistry (IHC) and correlations examined with clinical variables.ResultsExpression levels of the studied oncogenic and inflammatory tumor biomarkers were not differentially regulated by HIV status. Among patients with HIV-positive head and neck cancer, laryngeal disease site (P = .003) and Clavien-Dindo classification IV (CD4) counts

Published
2017

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