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1. Risk factors for head and neck cancer in more and less developed countries: Analysis from the INHANCE consortium.

Author

Goyal N, Hennessy M, Lehman E, Lin W, Agudo A, Ahrens W, Boccia S, Brennan P, Brenner H, Cadoni G, Canova C, Chen C, Conway D, Curado MP, Dal Maso L, Daudt AW, Edefonti V, Fabianova E, Fernandez L, Franceschi S, Garavello W, Gillison M, Hayes RB, Healy C, Herrero R, Holcatova I, Kanda JL, Kelsey K, Hansen BT, Koifman R, Lagiou P, La Vecchia C, Levi F, Li G, Lissowska J, Mendoza López R, Luce D, Macfarlane G, Mates D, Matsuo K, McClean M, Menezes A, Menvielle G, Morgenstern H, Moysich K, Negri E, Olshan AF, Pandics T, Polesel J, Purdue M, Radoi L, Ramroth H, Richiardi L, Schantz S, Schwartz SM, Serraino D, Shangina O, Smith E, Sturgis EM, Świątkowska B, Thomson P, Vaughan TL, Vilensky M, Winn DM, Wunsch-Filho V, Yu GP, Zevallos JP, Zhang ZF, Zheng T, Znaor A, Boffetta P, Hashibe M, Lee YA, and Muscat JE

Subjects
Humans, Female, Developing Countries, Case-Control Studies, Risk Factors, Alcohol Drinking epidemiology, Alcohol Drinking adverse effects, Ethanol, Head and Neck Neoplasms epidemiology, Laryngeal Neoplasms epidemiology
Abstract

Objective: We analyzed the pooled case-control data from the International Head and Neck Cancer Epidemiology (INHANCE) consortium to compare cigarette smoking and alcohol consumption risk factors for head and neck cancer between less developed and more developed countries., Subjects and Methods: The location of each study was categorized as either a less developed or more developed country. We compared the risk of overall head and neck cancer and cancer of specific anatomic subsites associated with cigarette smoking and alcohol consumption. Additionally, age and sex distribution between categories was compared., Results: The odds ratios for head and neck cancer sites associated with smoking duration differed between less developed and more developed countries. Smoking greater than 20 years conferred a higher risk for oral cavity and laryngeal cancer in more developed countries, whereas the risk was greater for oropharynx and hypopharynx cancer in less developed countries. Alcohol consumed for more than 20 years conferred a higher risk for oropharynx, hypopharynx, and larynx cancer in less developed countries. The proportion of cases that were young (<45 years) or female differed by country type for some HNC subsites., Conclusion: These findings suggest the degree of industrialization and economic development affects the relationship between smoking and alcohol with head and neck cancer., (© 2022 Wiley Periodicals LLC.)

Published
2023
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2. Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer.

Author

Bravi F, Lee YA, Hashibe M, Boffetta P, Conway DI, Ferraroni M, La Vecchia C, and Edefonti V

Subjects
Case-Control Studies, Humans, Risk Factors, Tobacco Use, Head and Neck Neoplasms epidemiology, Neoplasm Recurrence, Local
Abstract

Objective: To summarize the latest evidence on head and neck cancer epidemiology from the International Head and Neck Cancer Epidemiology (INHANCE) consortium., Subjects and Methods: INHANCE was established in 2004 to elucidate the etiology of head and neck cancer through pooled analyses of individual-level data on a large scale. We summarize results from recent INHANCE-based publications updating our 2015 overview., Results: Seventeen papers were published between 2015 and May 2020. These studies further define the nature of risks associated with tobacco and alcohol, and occupational exposures on head and neck cancer. The beneficial effects on incidence of head and neck cancer were identified for good oral health, endogenous and exogenous hormonal factors, and selected aspects of diet related to fruit and vegetables. INHANCE has begun to develop risk prediction models and to pool follow-up data on their studies, finding that ~30% of cases had cancer recurrence and 9% second primary cancers, with overall- and disease-specific 5-year-survival of 51% and 57%, respectively., Conclusions: The number and importance of INHANCE scientific findings provides further evidence of the advantages of large-scale internationally collaborative projects and will support the development of prevention strategies., (© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.)

Published
2021
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3. Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration.

Author

Di Credico G, Polesel J, Dal Maso L, Pauli F, Torelli N, Luce D, Radoï L, Matsuo K, Serraino D, Brennan P, Holcatova I, Ahrens W, Lagiou P, Canova C, Richiardi L, Healy CM, Kjaerheim K, Conway DI, Macfarlane GJ, Thomson P, Agudo A, Znaor A, Franceschi S, Herrero R, Toporcov TN, Moyses RA, Muscat J, Negri E, Vilensky M, Fernandez L, Curado MP, Menezes A, Daudt AW, Koifman R, Wunsch-Filho V, Olshan AF, Zevallos JP, Sturgis EM, Li G, Levi F, Zhang ZF, Morgenstern H, Smith E, Lazarus P, La Vecchia C, Garavello W, Chen C, Schwartz SM, Zheng T, Vaughan TL, Kelsey K, McClean M, Benhamou S, Hayes RB, Purdue MP, Gillison M, Schantz S, Yu GP, Chuang SC, Boffetta P, Hashibe M, Yuan-Chin AL, and Edefonti V

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Alcohol Drinking adverse effects, Alcohol Drinking pathology, Case-Control Studies, Female, Humans, Laryngeal Neoplasms epidemiology, Laryngeal Neoplasms etiology, Male, Middle Aged, Mouth Neoplasms epidemiology, Mouth Neoplasms etiology, Oropharyngeal Neoplasms epidemiology, Oropharyngeal Neoplasms etiology, Risk Factors, Severity of Illness Index, Smoking adverse effects, Smoking epidemiology, Smoking pathology, Time Factors, Young Adult, Alcohol Drinking epidemiology, Head and Neck Neoplasms epidemiology, Head and Neck Neoplasms etiology
Abstract

Background: Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk., Methods: Data from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking., Results: For all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx)., Conclusions: Present results further encourage the reduction of alcohol intensity to mitigate HNC risk.

Published
2020
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4. Dietary glycaemic index, glycaemic load and head and neck cancer risk: a pooled analysis in an international consortium.

Author

Chang CP, La Vecchia C, Serraino D, Olshan AF, Zevallos JP, Morgenstern H, Levi F, Garavello W, Kelsey K, McClean M, Chen C, Schwartz SM, Schantz S, Yu GP, Boffetta P, Hashibe M, Lee YA, Parpinel M, Augustin LSA, Turati F, Zhang ZF, and Edefonti V

Subjects
Case-Control Studies, Female, Head and Neck Neoplasms blood, Humans, Male, Surveys and Questionnaires, Glycemic Index physiology, Glycemic Load physiology, Head and Neck Neoplasms diagnosis
Abstract

High dietary glycaemic index (GI) and glycaemic load (GL) may increase cancer risk. However, limited information was available on GI and/or GL and head and neck cancer (HNC) risk. We conducted a pooled analysis on 8 case-control studies (4081 HNC cases; 7407 controls) from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. We estimated the odds ratios (ORs) and 95% confidence intervals (CIs) of HNC, and its subsites, from fixed- or mixed-effects logistic models including centre-specific quartiles of GI or GL. GI, but not GL, had a weak positive association with HNC (OR Q4 vs. Q1  = 1.16; 95% CI = 1.02-1.31). In subsites, we found a positive association between GI and laryngeal cancer (OR Q4 vs. Q1  = 1.60; 95% CI = 1.30-1.96) and an inverse association between GL and oropharyngeal cancer (OR Q4 vs. Q1  = 0.78; 95% CI = 0.63-0.97). This pooled analysis indicates a modest positive association between GI and HNC, mainly driven by laryngeal cancer.

Published
2020
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5. Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE).

Author

Chang CP, Chang SC, Chuang SC, Berthiller J, Ferro G, Matsuo K, Wünsch-Filho V, Toporcov TN, de Carvalho MB, La Vecchia C, Olshan AF, Zevallos JP, Serraino D, Muscat J, Sturgis EM, Li G, Morgenstern H, Levi F, Dal Maso L, Smith E, Kelsey K, McClean M, Vaughan TL, Lazarus P, Ramroth H, Chen C, Schwartz SM, Winn DM, Bosetti C, Edefonti V, Garavello W, Negri E, Hayes RB, Purdue MP, Boccia S, Cadoni G, Shangina O, Koifman R, Curado MP, Vilensky M, Swiatkowska B, Herrero R, Franceschi S, Benhamou S, Fernandez L, Menezes AMB, Daudt AW, Mates D, Schantz S, Yu GP, Lissowska J, Brenner H, Fabianova E, Rudnai P, Brennan P, Boffetta P, Zhang ZF, Hashibe M, and Lee YA

Subjects
Adult, Age Factors, Aged, Case-Control Studies, Female, Humans, Male, Middle Aged, Risk Factors, Head and Neck Neoplasms epidemiology, Head and Neck Neoplasms etiology, Nicotiana adverse effects
Abstract

Background: Tobacco use is a well-established risk factor for head and neck cancer (HNC). However, less is known about the potential impact of exposure to tobacco at an early age on HNC risk., Methods: We analyzed individual-level data on ever tobacco smokers from 27 case-control studies (17,146 HNC cases and 17,449 controls) in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using random-effects logistic regression models., Results: Without adjusting for tobacco packyears, we observed that younger age at starting tobacco use was associated with an increased HNC risk for ever smokers (OR <10 years vs. ≥30 years : 1.64, 95% CI: 1.35, 1.97). However, the observed association between age at starting tobacco use and HNC risk became null after adjusting for tobacco packyears (OR <10 years vs. ≥30 years : 0.97, 95% CI: 0.80, 1.19). In the stratified analyses on HNC subsites by tobacco packyears or years since quitting, no difference in the association between age at start and HNC risk was observed., Conclusions: Results from this pooled analysis suggest that increased HNC risks observed with earlier age at starting tobacco smoking are largely due to longer duration and higher cumulative tobacco exposures., (Copyright © 2019 Elsevier Ltd. All rights reserved.)

Published
2019
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6. Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach.

Author

Di Credico G, Edefonti V, Polesel J, Pauli F, Torelli N, Serraino D, Negri E, Luce D, Stucker I, Matsuo K, Brennan P, Vilensky M, Fernandez L, Curado MP, Menezes A, Daudt AW, Koifman R, Wunsch-Filho V, Holcatova I, Ahrens W, Lagiou P, Simonato L, Richiardi L, Healy C, Kjaerheim K, Conway DI, Macfarlane TV, Thomson P, Agudo A, Znaor A, Boaventura Rios LF, Toporcov TN, Franceschi S, Herrero R, Muscat J, Olshan AF, Zevallos JP, La Vecchia C, Winn DM, Sturgis EM, Li G, Fabianova E, Lissowska J, Mates D, Rudnai P, Shangina O, Swiatkowska B, Moysich K, Zhang ZF, Morgenstern H, Levi F, Smith E, Lazarus P, Bosetti C, Garavello W, Kelsey K, McClean M, Ramroth H, Chen C, Schwartz SM, Vaughan TL, Zheng T, Menvielle G, Boccia S, Cadoni G, Hayes RB, Purdue M, Gillison M, Schantz S, Yu GP, Brenner H, D'Souza G, Gross ND, Chuang SC, Boffetta P, Hashibe M, Lee YA, and Dal Maso L

Subjects
Adult, Aged, Aged, 80 and over, Case-Control Studies, Female, Head and Neck Neoplasms pathology, Humans, Male, Middle Aged, Risk Factors, Cigarette Smoking adverse effects, Head and Neck Neoplasms etiology
Abstract

Objectives: This study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures., Materials and Methods: We pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework., Results: For oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of ∼20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs >20 were found for current smokers of ≥20 cigarettes/day for ≥30  years. In former smokers who quit ≥10  years ago, the ORs were approximately halved for OCP cancers, and ∼1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers., Conclusion: Referring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies., (Copyright © 2019 Elsevier Ltd. All rights reserved.)

Published
2019
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7. Shared and Study-specific Dietary Patterns and Head and Neck Cancer Risk in an International Consortium.

Author

De Vito R, Lee YCA, Parpinel M, Serraino D, Olshan AF, Zevallos JP, Levi F, Zhang ZF, Morgenstern H, Garavello W, Kelsey K, McClean M, Schantz S, Yu GP, Boffetta P, Chuang SC, Hashibe M, La Vecchia C, Parmigiani G, and Edefonti V

Subjects
Adult, Aged, Aged, 80 and over, Case-Control Studies, Confidence Intervals, Europe epidemiology, Female, Humans, Male, Middle Aged, Odds Ratio, Reproducibility of Results, United States epidemiology, Diet, Head and Neck Neoplasms epidemiology
Abstract

Background: A few papers have considered reproducibility of a posteriori dietary patterns across populations, as well as pattern associations with head and neck cancer risk when multiple populations are available., Methods: We used individual-level pooled data from seven case-control studies (3844 cases; 6824 controls) participating in the International Head and Neck Cancer Epidemiology consortium. We simultaneously derived shared and study-specific a posteriori patterns with a novel approach called multi-study factor analysis applied to 23 nutrients. We derived odds ratios (ORs) and 95% confidence intervals (CIs) for cancers of the oral cavity and pharynx combined, and larynx, from logistic regression models., Results: We identified three shared patterns that were reproducible across studies (75% variance explained): the Antioxidant vitamins and fiber (OR = 0.57, 95% CI = 0.41, 0.78, highest versus lowest score quintile) and the Fats (OR = 0.80, 95% CI = 0.67, 0.95) patterns were inversely associated with oral and pharyngeal cancer risk. The Animal products and cereals (OR = 1.5, 95% CI = 1.1, 2.1) and the Fats (OR = 1.8, 95% CI = 1.4, 2.3) patterns were positively associated with laryngeal cancer risk, whereas a linear inverse trend in laryngeal cancer risk was evident for the Antioxidant vitamins and fiber pattern. We also identified four additional study-specific patterns, one for each of the four US studies examined. We named them all as Dairy products and breakfast cereals, and two were associated with oral and pharyngeal cancer risk., Conclusion: Multi-study factor analysis provides insight into pattern reproducibility and supports previous evidence on cross-country reproducibility of dietary patterns and on their association with head and neck cancer risk. See video abstract at, http://links.lww.com/EDE/B430.

Published
2019
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8. Dietary fiber intake and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology consortium.

Author

Kawakita D, Lee YA, Turati F, Parpinel M, Decarli A, Serraino D, Matsuo K, Olshan AF, Zevallos JP, Winn DM, Moysich K, Zhang ZF, Morgenstern H, Levi F, Kelsey K, McClean M, Bosetti C, Garavello W, Schantz S, Yu GP, Boffetta P, Chuang SC, Hashibe M, Ferraroni M, La Vecchia C, and Edefonti V

Subjects
Adult, Aged, Alcohol Drinking adverse effects, Carcinoma, Squamous Cell pathology, Case-Control Studies, Female, Head and Neck Neoplasms epidemiology, Head and Neck Neoplasms pathology, Humans, Laryngeal Neoplasms diet therapy, Laryngeal Neoplasms pathology, Male, Middle Aged, Pharyngeal Neoplasms diet therapy, Pharyngeal Neoplasms pathology, Risk Factors, Squamous Cell Carcinoma of Head and Neck, Nicotiana adverse effects, Carcinoma, Squamous Cell diet therapy, Dietary Fiber therapeutic use, Head and Neck Neoplasms diet therapy
Abstract

The possible role of dietary fiber in the etiology of head neck cancers (HNCs) is unclear. We used individual-level pooled data from ten case-control studies (5959 cases and 12,248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium, to examine the association between fiber intake and cancer of the oral cavity/pharynx and larynx. Odds Ratios (ORs) and their 95% Confidence Intervals (CIs) were estimated using unconditional multiple logistic regression applied to quintile categories of non-alcohol energy-adjusted fiber intake and adjusted for tobacco and alcohol use and other known or putative confounders. Fiber intake was inversely associated with oral and pharyngeal cancer combined (OR for 5th vs. 1st quintile category = 0.49, 95% CI: 0.40-0.59; p for trend <0.001) and with laryngeal cancer (OR = 0.66, 95% CI: 0.54-0.82, p for trend <0.001). There was, however, appreciable heterogeneity of the estimated effect across studies for oral and pharyngeal cancer combined. Nonetheless, inverse associations were consistently observed for the subsites of oral and pharyngeal cancers and within most strata of the considered covariates, for both cancer sites. Our findings from a multicenter large-scale pooled analysis suggest that, although in the presence of between-study heterogeneity, a greater intake of fiber may lower HNC risk., (© 2017 UICC.)

Published
2017
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9. Carotenoid intake and head and neck cancer: a pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.

Author

Leoncini E, Edefonti V, Hashibe M, Parpinel M, Cadoni G, Ferraroni M, Serraino D, Matsuo K, Olshan AF, Zevallos JP, Winn DM, Moysich K, Zhang ZF, Morgenstern H, Levi F, Kelsey K, McClean M, Bosetti C, Schantz S, Yu GP, Boffetta P, Lee YC, Chuang SC, Decarli A, La Vecchia C, and Boccia S

Subjects
Adult, Aged, Aged, 80 and over, Antioxidants therapeutic use, Carcinoma, Squamous Cell epidemiology, Case-Control Studies, Epidemiologic Studies, Europe epidemiology, Female, Head and Neck Neoplasms epidemiology, Humans, Japan epidemiology, Middle Aged, Squamous Cell Carcinoma of Head and Neck, United States epidemiology, Carcinoma, Squamous Cell prevention & control, Carotenoids therapeutic use, Head and Neck Neoplasms prevention & control
Abstract

Food and nutrition play an important role in head and neck cancer (HNC) etiology; however, the role of carotenoids remains largely undefined. We explored the relation of HNC risk with the intake of carotenoids within the International Head and Neck Cancer Epidemiology Consortium. We pooled individual-level data from 10 case-control studies conducted in Europe, North America, and Japan. The analysis included 18,207 subjects (4414 with oral and pharyngeal cancer, 1545 with laryngeal cancer, and 12,248 controls), categorized by quintiles of carotenoid intake from natural sources. Comparing the highest with the lowest quintile, the risk reduction associated with total carotenoid intake was 39 % (95 % CI 29-47 %) for oral/pharyngeal cancer and 39 % (95 % CI 24-50 %) for laryngeal cancer. Intakes of β-carotene equivalents, β-cryptoxanthin, lycopene, and lutein plus zeaxanthin were associated with at least 18 % reduction in the rate of oral and pharyngeal cancer (95 % CI 6-29 %) and 17 % reduction in the rate of laryngeal cancer (95 % CI 0-32 %). The overall protective effect of carotenoids on HNC was stronger for subjects reporting greater alcohol consumption (p < 0.05). The odds ratio for the combined effect of low carotenoid intake and high alcohol or tobacco consumption versus high carotenoid intake and low alcohol or tobacco consumption ranged from 7 (95 % CI 5-9) to 33 (95 % CI 23-49). A diet rich in carotenoids may protect against HNC. Persons with both low carotenoid intake and high tobacco or alcohol are at substantially higher risk of HNC.

Published
2016
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10. Natural vitamin C intake and the risk of head and neck cancer: A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.

Author

Edefonti V, Hashibe M, Parpinel M, Turati F, Serraino D, Matsuo K, Olshan AF, Zevallos JP, Winn DM, Moysich K, Zhang ZF, Morgenstern H, Levi F, Kelsey K, McClean M, Bosetti C, Galeone C, Schantz S, Yu GP, Boffetta P, Amy Lee YC, Chuang SC, La Vecchia C, and Decarli A

Subjects
Case-Control Studies, Humans, Italy epidemiology, Japan epidemiology, Logistic Models, Risk Factors, Switzerland epidemiology, United States epidemiology, Vitamins administration & dosage, Ascorbic Acid administration & dosage, Head and Neck Neoplasms epidemiology, International Agencies statistics & numerical data, Surveys and Questionnaires
Abstract

Evidence of associations between single nutrients and head and neck cancer (HNC) is still more limited and less consistent than that for fruit and vegetables. However, clarification of the protective mechanisms of fruit and vegetables is important to our understanding of HNC etiology. We investigated the association between vitamin C intake from natural sources and cancer of the oral cavity/pharynx and larynx using individual-level pooled data from ten case-control studies (5,959 cases and 12,248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. After harmonization of study-specific exposure information via the residual method, adjusted odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using unconditional multiple logistic regression models on quintile categories of 'non-alcohol energy-adjusted' vitamin C intake. In the presence of heterogeneity of the estimated ORs among studies, we derived those estimates from generalized linear mixed models. Higher intakes of vitamin C were inversely related to oral and pharyngeal (OR = 0.54, 95% CI: 0.45-0.65, for the fifth quintile category versus the first one, p for trend<0.001) and laryngeal cancers (OR = 0.52, 95% CI: 0.40-0.68, p for trend = 0.006), although in the presence of heterogeneity among studies for both sites. Inverse associations were consistently observed for the anatomical subsites of oral and pharyngeal cancer, and across strata of age, sex, education, body mass index, tobacco, and alcohol, for both cancer sites. The inverse association of vitamin C intake from foods with HNC may reflect a protective effect on these cancers; however, we cannot rule out other explanations., (© 2014 UICC.)

Published
2015
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11. Carotenoid Intake from Natural Sources and Head and Neck Cancer: A Systematic Review and Meta-analysis of Epidemiological Studies.

Author

Leoncini E, Nedovic D, Panic N, Pastorino R, Edefonti V, and Boccia S

Subjects
Antioxidants therapeutic use, Epidemiologic Studies, Global Health, Head and Neck Neoplasms epidemiology, Humans, Morbidity trends, Risk Factors, Carotenoids therapeutic use, Dietary Supplements, Head and Neck Neoplasms prevention & control
Abstract

Because of their role as antioxidants, the intake of carotenoids has been hypothesized to reduce the risk of head and neck cancer (HNC). We conducted a systematic review and meta-analysis of the epidemiological studies to investigate whether the intake of specific carotenoids from dietary sources, as well as combined carotenoids, is associated with the risk of HNC according to cancer subsites. A comprehensive literature search of the Medline and Scopus databases was conducted. Sixteen articles were identified from the literature search, of which 15 were case-control studies and one prospective cohort study. The risk reduction associated with β-carotene equivalents intake was 46% (95% CI, 20%-63%) for cancer of oral cavity and 57% (95% CI, 23%-76%) for laryngeal cancer. Lycopene and β-cryptoxanthin also reduced the risk for laryngeal cancer; the ORs for the highest category compared with the lowest one of carotenoid intake were 50% (95% CI, 11%-72%) and 59% (95% CI, 49%-67%), respectively. Lycopene, α-carotene, and β-cryptoxanthin were associated with at least 26% reduction in the rate of oral and pharyngeal cancer (95% CI, 2%-44%). Our systematic review and meta-analysis on dietary carotenoids intake and HNC showed carotenoids to act protectively against HNC, in relation to most of single nutrients and subsites., (©2015 American Association for Cancer Research.)

Published
2015
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12. Vitamin E intake from natural sources and head and neck cancer risk: a pooled analysis in the International Head and Neck Cancer Epidemiology consortium.

Author

Edefonti V, Hashibe M, Parpinel M, Ferraroni M, Turati F, Serraino D, Matsuo K, Olshan AF, Zevallos JP, Winn DM, Moysich K, Zhang ZF, Morgenstern H, Levi F, Kelsey K, McClean M, Bosetti C, Schantz S, Yu GP, Boffetta P, Chuang SC, A Lee YC, La Vecchia C, and Decarli A

Subjects
Adult, Aged, Female, Humans, Male, Head and Neck Neoplasms epidemiology, Vitamin E administration & dosage
Abstract

Background: Evidence for the possible effect of vitamin E on head and neck cancers (HNCs) is limited., Methods: We used individual-level pooled data from 10 case-control studies (5959 cases and 12 248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium to assess the association between vitamin E intake from natural sources and cancer of the oral cavity/pharynx and larynx. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression models applied to quintile categories of non-alcohol energy-adjusted vitamin E intake., Results: Intake of vitamin E was inversely related to oral/pharyngeal cancer (OR for the fifth vs the first quintile category=0.59, 95% CI: 0.49-0.71; P for trend <0.001) and to laryngeal cancer (OR=0.67, 95% CI: 0.54-0.83, P for trend <0.001). There was, however, appreciable heterogeneity of the estimated effect across studies for oral/pharyngeal cancer. Inverse associations were generally observed for the anatomical subsites of oral and pharyngeal cancer and within covariate strata for both sites., Conclusion: Our findings suggest that greater vitamin E intake from foods may lower HNC risk, although we were not able to explain the heterogeneity observed across studies or rule out certain sources of bias.

Published
2015
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13. Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries.

Author

Conway DI, Brenner DR, McMahon AD, Macpherson LM, Agudo A, Ahrens W, Bosetti C, Brenner H, Castellsague X, Chen C, Curado MP, Curioni OA, Dal Maso L, Daudt AW, de Gois Filho JF, D'Souza G, Edefonti V, Fabianova E, Fernandez L, Franceschi S, Gillison M, Hayes RB, Healy CM, Herrero R, Holcatova I, Jayaprakash V, Kelsey K, Kjaerheim K, Koifman S, La Vecchia C, Lagiou P, Lazarus P, Levi F, Lissowska J, Luce D, Macfarlane TV, Mates D, Matos E, McClean M, Menezes AM, Menvielle G, Merletti F, Morgenstern H, Moysich K, Müller H, Muscat J, Olshan AF, Purdue MP, Ramroth H, Richiardi L, Rudnai P, Schantz S, Schwartz SM, Shangina O, Simonato L, Smith E, Stucker I, Sturgis EM, Szeszenia-Dabrowska N, Talamini R, Thomson P, Vaughan TL, Wei Q, Winn DM, Wunsch-Filho V, Yu GP, Zhang ZF, Zheng T, Znaor A, Boffetta P, Chuang SC, Ghodrat M, Amy Lee YC, Hashibe M, and Brennan P

Subjects
Case-Control Studies, Female, Follow-Up Studies, Global Health, Humans, Male, Meta-Analysis as Topic, Middle Aged, Prognosis, Risk Factors, Socioeconomic Factors, Alcohol Drinking adverse effects, Education, Head and Neck Neoplasms etiology, Income statistics & numerical data, Smoking adverse effects
Abstract

Low socioeconomic status has been reported to be associated with head and neck cancer risk. However, previous studies have been too small to examine the associations by cancer subsite, age, sex, global region and calendar time and to explain the association in terms of behavioral risk factors. Individual participant data of 23,964 cases with head and neck cancer and 31,954 controls from 31 studies in 27 countries pooled with random effects models. Overall, low education was associated with an increased risk of head and neck cancer (OR = 2.50; 95% CI = 2.02 - 3.09). Overall one-third of the increased risk was not explained by differences in the distribution of cigarette smoking and alcohol behaviors; and it remained elevated among never users of tobacco and nondrinkers (OR = 1.61; 95% CI = 1.13 - 2.31). More of the estimated education effect was not explained by cigarette smoking and alcohol behaviors: in women than in men, in older than younger groups, in the oropharynx than in other sites, in South/Central America than in Europe/North America and was strongest in countries with greater income inequality. Similar findings were observed for the estimated effect of low versus high household income. The lowest levels of income and educational attainment were associated with more than 2-fold increased risk of head and neck cancer, which is not entirely explained by differences in the distributions of behavioral risk factors for these cancers and which varies across cancer sites, sexes, countries and country income inequality levels., (© 2014 UICC.)

Published
2015
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14. Dietary fiber intake and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology consortium

Author

Kawakita, D., Lee, Y. -C. A., Turati, F., Parpinel, M., Decarli, A., Serraino, D., Matsuo, K., Olshan, A. F., Zevallos, J. P., Winn, D. M., Moysich, K., Zhang, Z. -F., Morgenstern, H., Levi, F., Kelsey, K., McClean, M., Bosetti, C., Garavello, W., Schantz, S., Yu, G. -P., Boffetta, P., Chuang, S. -C., Hashibe, M., Ferraroni, M., La Vecchia, C., Edefonti, V., Kawakita, D, Lee, Y, Turati, F, Parpinel, M, Decarli, A, Serraino, D, Matsuo, K, Olshan, A, Zevallos, J, Winn, D, Moysich, K, Zhang, Z, Morgenstern, H, Levi, F, Kelsey, K, Mcclean, M, Bosetti, C, Garavello, W, Schantz, S, Yu, G, Boffetta, P, Chuang, S, Hashibe, M, Ferraroni, M, La Vecchia, C, Edefonti, V, and Kawakita, D. and Lee, Y.-C.A. and Turati, F. and Parpinel, M. and Decarli, A. and Serraino, D. and Matsuo, K. and Olshan, A.F. and Zevallos, J.P. and Winn, D.M. and Moysich, K. and Zhang, Z.-F. and Morgenstern, H. and Levi, F. and Kelsey, K. and McClean, M. and Bosetti, C. and Garavello, W. and Schantz, S. and Yu, G.-P. and Boffetta, P. and Chuang, S.-C. and Hashibe, M. and Ferraroni, M. and La Vecchia, C. and Edefonti, V.

Subjects
squamous cell carcinoma, tobacco, Adult, Dietary Fiber, Male, Cancer Research, larynx tumor, epidemiological data, pharynx cancer, dietary fiber intake, cancer risk, Oral and gastrointestinal, tobacco consumption, INHANCE, head and neck cancer, laryngeal cancer, oral cavity and pharyngeal cancer, Risk Factors, Cancer, Head and Neck Neoplasm, drinking behavior, Middle Aged, priority journal, Oncology, Head and Neck Neoplasms, Adult, Aged, Alcohol Drinking, Carcinoma, Squamous Cell, Case-Control Studies, Female, Humans, Laryngeal Neoplasms, Pharyngeal Neoplasms, Tobacco, Case-Control Studie, Human, alcohol consumption, Oncology and Carcinogenesis, Article, Rare Diseases, adverse effect, controlled study, Pharyngeal Neoplasm, Oncology & Carcinogenesis, Dental/Oral and Craniofacial Disease, Laryngeal Neoplasm, Squamous Cell Carcinoma of Head and Neck, Risk Factor, Prevention, disease association, Carcinoma, larynx cancer, case control study, mouth cancer, major clinical study, Good Health and Well Being, diet therapy, Squamous Cell, therapeutic use, pathology, dietary intake, Digestive Diseases
Abstract

The possible role of dietary fiber in the etiology of head neck cancers (HNCs) is unclear. We used individual-level pooled data from ten case-control studies (5959 cases and 12,248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium, to examine the association between fiber intake and cancer of the oral cavity/pharynx and larynx. Odds Ratios (ORs) and their 95% Confidence Intervals (CIs) were estimated using unconditional multiple logistic regression applied to quintile categories of non-alcohol energy-adjusted fiber intake and adjusted for tobacco and alcohol use and other known or putative confounders. Fiber intake was inversely associated with oral and pharyngeal cancer combined (OR for 5th vs. 1st quintile category = 0.49, 95% CI: 0.40–0.59; p for trend

Published
2017

15. Natural vitamin C intake and the risk of head and neck cancer: A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium

Author

Edefonti, V., Hashibe, M., Parpinel, M., Turati, F., Serraino, D., Matsuo, K., Olshan, A. F., Zevallos, J. P., Winn, D. M., Moysich, K., Zhang, Z. -F., Morgenstern, H., Levi, F., Kelsey, K., McClean, M., Bosetti, C., Galeone, C., Schantz, S., Yu, G. -P., Boffetta, P., Amy Lee, Y. -C., Chuang, S. -C., La Vecchia, C., Decarli, A., Edefonti, V., Hashibe, M., Parpinel, M., Turati, F., Serraino, D., Matsuo, K., Olshan, A.F., Zevallos, J.P., Winn, D.M., Moysich, K., Zhang, Z.-F., Morgenstern, H., Levi, F., Kelsey, K., McClean, M., Bosetti, C., Galeone, C., Schantz, S., Yu, G.-P., Boffetta, P., Amy Lee, Y.-C., Chuang, S.-C., La Vecchia, C., and Decarli, A.

Subjects
INHANCE, Oncology and Carcinogenesis, INHANCE, head and neck cancer, laryngeal cancer, oral and pharyngeal cancer, vitamin C, vitamin C, Natural vitamin C - head and neck cancer, oral and pharyngeal cancer, Ascorbic Acid, Rare Diseases, Japan, Risk Factors, Surveys and Questionnaires, Humans, Oncology & Carcinogenesis, Dental/Oral and Craniofacial Disease, Nutrition, Cancer, Prevention, International Agencies, Vitamins, United States, Logistic Models, Good Health and Well Being, Italy, Head and Neck Neoplasms, Case-Control Studies, laryngeal cancer, head and neck cancer, Digestive Diseases, Switzerland
Abstract

Evidence of associations between single nutrients and head and neck cancer (HNC) is still more limited and less consistent than that for fruit and vegetables. However, clarification of the protective mechanisms of fruit and vegetables is important to our understanding of HNC etiology. We investigated the association between vitamin C intake from natural sources and cancer of the oral cavity/pharynx and larynx using individual-level pooled data from ten case-control studies (5,959 cases and 12,248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. After harmonization of study-specific exposure information via the residual method, adjusted odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using unconditional multiple logistic regression models on quintile categories of 'non-alcohol energy-adjusted' vitamin C intake. In the presence of heterogeneity of the estimated ORs among studies, we derived those estimates from generalized linear mixed models. Higher intakes of vitamin C were inversely related to oral and pharyngeal (OR = 0.54, 95% CI: 0.45-0.65, for the fifth quintile category versus the first one, p for trend

Published
2015

16. Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer

Author

Bravi, Francesca, Lee, Yuan‐Chin Amy, Hashibe, Mia, Boffetta, Paolo, Conway, David I., Ferraroni, Monica, La Vecchia, Carlo, Edefonti, Valeria, Agudo, Antonio, Ahrens, Wolfgang, Benhamou, Simone, Boccia, Stefania, Brennan, Paul, Brenner, Hermann, Cadoni, Gabriella, Canova, Cristina, Chen, Chu, Chuang, Shu‐Chun, Curado, Maria Paula, Dal Maso, Luigino, Daudt, Alexander W., D'Souza, Gypsyamber, Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Garavello, Werner, Gillison, Maura, Gross, Neil D., Hayes, Richard B., Healy, Claire, Herrero, Rolando, Holcatova, Ivana, Kelsey, Karl, Kjaerheim, Kristina, Koifman, Rosalina, Lagiou, Pagona, Lazarus, Philip, Levi, Fabio, Li, Guojun, Lissowska, Jolanta, Luce, Daniele, Macfarlane, Gary J., Mates, Dana, Matsuo, Keitaro, McClean, Michael, Menezes, Ana, Menvielle, Gwenn, Morgenstern, Hal, Moyses, Raquel A., Moysich, Kirsten, Muscat, Joshua, Negri, Eva, Olshan, Andrew F., Pandics, Tamas, Polesel, Jerry, Purdue, Mark P., Radoï, Loredana, Ramroth, Heribert, Richiardi, Lorenzo, Schantz, Stimson, Schwartz, Stephen M., Serraino, Diego, Shangina, Oxana, Smith, Elaine, Sturgis, Erich M., Świątkowska, Beata, Thomson, Peter, Toporcov, Tatiana N., Vaughan, Thomas L., Vilensky, Marta, Winn, Deborah M., Wunsch‐Filho, Victor, Yu, Guo‐Pei, Zevallos, Jose P, Zhang, Zuo‐Feng, Zheng, Tongzhang, Znaor, Ariana, Bravi, F, Lee, Y, Hashibe, M, Boffetta, P, Conway, D, Ferraroni, M, La Vecchia, C, Edefonti, V, Agudo, A, Ahrens, W, Benhamou, S, Boccia, S, Brennan, P, Brenner, H, Cadoni, G, Canova, C, Chen, C, Chuang, S, Curado, M, Dal Maso, L, Daudt, A, D'Souza, G, Fabianova, E, Fernandez, L, Franceschi, S, Garavello, W, Gillison, M, Gross, N, Hayes, R, Healy, C, Herrero, R, Holcatova, I, Kelsey, K, Kjaerheim, K, Koifman, R, Lagiou, P, Lazarus, P, Levi, F, Li, G, Lissowska, J, Luce, D, Macfarlane, G, Mates, D, Matsuo, K, Mcclean, M, Menezes, A, Menvielle, G, Morgenstern, H, Moyses, R, Moysich, K, Muscat, J, Negri, E, Olshan, A, Pandics, T, Polesel, J, Purdue, M, Radoi, L, Ramroth, H, Richiardi, L, Schantz, S, Schwartz, S, Serraino, D, Shangina, O, Smith, E, Sturgis, E, Swiatkowska, B, Thomson, P, Toporcov, T, Vaughan, T, Vilensky, M, Winn, D, Wunsch-Filho, V, Yu, G, Zevallos, J, Zhang, Z, Zheng, T, Znaor, A, Bravi F., Lee Y.-C.A., Hashibe M., Boffetta P., Conway D.I., Ferraroni M., La Vecchia C., Edefonti V., Agudo A., Ahrens W., Benhamou S., Boccia S., Brennan P., Brenner H., Cadoni G., Canova C., Chen C., Chuang S.-C., Curado M.P., Dal Maso L., Daudt A.W., D'Souza G., Fabianova E., Fernandez L., Franceschi S., Garavello W., Gillison M., Gross N.D., Hayes R.B., Healy C., Herrero R., Holcatova I., Kelsey K., Kjaerheim K., Koifman R., Lagiou P., Lazarus P., Levi F., Li G., Lissowska J., Luce D., Macfarlane G.J., Mates D., Matsuo K., McClean M., Menezes A., Menvielle G., Morgenstern H., Moyses R.A., Moysich K., Muscat J., Negri E., Olshan A.F., Pandics T., Polesel J., Purdue M.P., Radoi L., Ramroth H., Richiardi L., Schantz S., Schwartz S.M., Serraino D., Shangina O., Smith E., Sturgis E.M., Swiatkowska B., Thomson P., Toporcov T.N., Vaughan T.L., Vilensky M., Winn D.M., Wunsch-Filho V., Yu G.-P., Zevallos J.P., Zhang Z.-F., Zheng T., and Znaor A.

Subjects
INHANCE, medicine.medical_specialty, Oral health, Cancer recurrence, Article, Tobacco Use, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Epidemiology, medicine, Humans, pooled analysi, prognostic factor, General Dentistry, Beneficial effects, Head and Neck Neoplasm, business.industry, Incidence (epidemiology), Head and neck cancer, oral cavity cancer, Case-control study, prognostic factors, 030206 dentistry, medicine.disease, risk factor, Otorhinolaryngology, Head and Neck Neoplasms, Case-Control Studies, 030220 oncology & carcinogenesis, Family medicine, Etiology, laryngeal cancer, head and neck cancer, Settore MED/31 - OTORINOLARINGOIATRIA, pooled analysis, Neoplasm Recurrence, Local, Case-Control Studie, business, Human
Abstract

Objective:\ud \ud To summarize the latest evidence on head and neck cancer epidemiology from the International Head and Neck Cancer Epidemiology (INHANCE) consortium.\ud \ud Subjects and Methods:\ud \ud INHANCE was established in 2004 to elucidate the etiology of head and neck cancer through pooled analyses of individual‐level data on a large scale. We summarize results from recent INHANCE‐based publications updating our 2015 overview.\ud \ud Results:\ud \ud Seventeen papers were published between 2015 and May 2020. These studies further define the nature of risks associated with tobacco and alcohol, and occupational exposures on head and neck cancer. The beneficial effects on incidence of head and neck cancer were identified for good oral health, endogenous and exogenous hormonal factors, and selected aspects of diet related to fruit and vegetables. INHANCE has begun to develop risk prediction models and to pool follow‐up data on their studies, finding that ~30% of cases had cancer recurrence and 9% second primary cancers, with overall‐ and disease‐specific 5‐year‐survival of 51% and 57%, respectively.\ud \ud Conclusions:\ud \ud The number and importance of INHANCE scientific findings provides further evidence of the advantages of large‐scale internationally collaborative projects and will support the development of prevention strategies.

Published
2020

17. Shared and Study-specific Dietary Patterns and Head and Neck Cancer Risk in an International Consortium

Author

Hal Morgenstern, Guo Pei Yu, Mia Hashibe, Diego Serraino, Andrew F. Olshan, Werner Garavello, Stimson P. Schantz, C. La Vecchia, Fabio Levi, R. De Vito, Yuan Chin Amy Lee, Shu Chun Chuang, Zhuo Feng Zhang, Giovanni Parmigiani, Maria Parpinel, Valeria Edefonti, Paolo Boffetta, Jose P. Zevallos, Michael D. McClean, Karl T. Kelsey, De Vito, R, Lee, Y, Parpinel, M, Serraino, D, Olshan, A, Zevallos, J, Levi, F, Zhang, Z, Morgenstern, H, Garavello, W, Kelsey, K, Mcclean, M, Schantz, S, Yu, G, Boffetta, P, Chuang, S, Hashibe, M, La Vecchia, C, Parmigiani, G, Edefonti, V, De Vito, R., Lee, Yuan Chin Amy, Parpinel, M., Serraino, D., Olshan, Andrew Fergu, Zevallos, Jose Pedro, Levi, F., Zhang, Zhuo Feng, Morgenstern, H., Garavello, W., Kelsey, K., McClean, M., Schantz, S., Yu, Guo Pei, Boffetta, P., Chuang, Shu Chun, Hashibe, M., La Vecchia, C., Parmigiani, G., and Edefonti, V.

Subjects
Male, Reproducibility of results, Epidemiology, Pharyngeal neoplasm, Mediterranean, Logistic regression, 01 natural sciences, 010104 statistics & probability, 0302 clinical medicine, Odds Ratio, 80 and over, Medicine, 030212 general & internal medicine, high-fat, Cancer, Aged, 80 and over, Mouth neoplasm, pharyngeal neoplasms, Head and Neck Neoplasm, Statistics, Middle Aged, Explained variation, Laryngeal neoplasms, Europe, Public Health and Health Services, Female, Case-Control Studie, Western, Human, Pharyngeal neoplasms, United State, Adult, medicine.medical_specialty, diet, Mediterranean, diet, high-fat, diet, Western, head and neck neoplasms, laryngeal neoplasms, mouth neoplasms, reproducibility of results, Reproducibility of Result, Head and neck neoplasms, Article, 03 medical and health sciences, Clinical Research, Internal medicine, Confidence Intervals, Humans, Dental/Oral and Craniofacial Disease, 0101 mathematics, Aged, Nutrition, business.industry, Prevention, Head and neck cancer, Case-control study, Odds ratio, Mouth neoplasms, medicine.disease, United States, Confidence interval, Laryngeal neoplasm, Diet, Case-Control Studies, diet, business, Confidence Interval
Abstract

BACKGROUND: A few papers have considered reproducibility of a posteriori dietary patterns across populations, as well as pattern associations with head and neck cancer risk when multiple populations are available. METHODS: We used individual-level pooled data from seven case-control studies (3844 cases; 6824 controls) participating in the International Head and Neck Cancer Epidemiology consortium. We simultaneously derived shared and study-specific a posteriori patterns with a novel approach called multi-study factor analysis applied to 23 nutrients. We derived odds ratios (ORs) and 95% confidence intervals (CIs) for cancers of the oral cavity and pharynx combined, and larynx, from logistic regression models. RESULTS: We identified three shared patterns that were reproducible across studies (75% variance explained): the Antioxidant vitamins and fiber (OR = 0.57, 95% CI = 0.41, 0.78, highest versus lowest score quintile) and the Fats (OR = 0.80, 95% CI = 0.67, 0.95) patterns were inversely associated with oral and pharyngeal cancer risk. The Animal products and cereals (OR = 1.5, 95% CI = 1.1, 2.1) and the Fats (OR = 1.8, 95% CI = 1.4, 2.3) patterns were positively associated with laryngeal cancer risk, whereas a linear inverse trend in laryngeal cancer risk was evident for the Antioxidant vitamins and fiber pattern. We also identified four additional study-specific patterns, one for each of the four US studies examined. We named them all as Dairy products and breakfast cereals, and two were associated with oral and pharyngeal cancer risk. CONCLUSION: Multi-study factor analysis provides insight into pattern reproducibility and supports previous evidence on cross-country reproducibility of dietary patterns and on their association with head and neck cancer risk. See video abstract at, http://links.lww.com/EDE/B430.

Published
2019

18. Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration

Author

Hal Morgenstern, Tongzhang Zheng, Chu Chen, Silvia Franceschi, Ivana Holcatova, Alexander W. Daudt, Fabio Levi, Diego Serraino, Danièle Luce, Marta Vilensky, Paul Brennan, Mark P. Purdue, Joshua E. Muscat, Lorenzo Richiardi, Shu Chun Chuang, Nicola Torelli, Erich M. Sturgis, Valeria Edefonti, Simone Benhamou, Carlo La Vecchia, Leticia Fernandez, Ariana Znaor, Werner Garavello, Raquel Ajub Moyses, Pagona Lagiou, Rosalina Jorge Koifman, Guojun Li, Elaine M. Smith, Philip Lazarus, Gary J. Macfarlane, Maura L. Gillison, David I. Conway, Keitaro Matsuo, Paolo Boffetta, Jose P. Zevallos, Luigino Dal Maso, Karl T. Kelsey, Ana M. B. Menezes, Maria Paula Curado, Zuo-Feng Zhang, Francesco Pauli, Victor Wünsch-Filho, Stephen M. Schwartz, Kristina Kjærheim, Antonio Agudo, Rolando Herrero, Guo Pei Yu, Cristina Canova, Mia Hashibe, Loredana Radoï, Wolfgang Ahrens, Michael D. McClean, Gioia Di Credico, Andrew F. Olshan, Jerry Polesel, Claire M. Healy, Thomas L. Vaughan, Amy Lee Yuan-Chin, Eva Negri, Peter Thomson, Tatiana Natasha Toporcov, Stimson P. Schantz, Richard B. Hayes, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Mode de vie, génétique et santé : études intégratives et transgénérationnelles (U1018 (Équipe 9)), Institut Gustave Roussy (IGR)-Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institute of Genetic Medicine [Newcastle], Newcastle University [Newcastle], Charles University [Prague] (CU), Bremen Institute for Prevention Research and Social Medicine (BIPS), Division of Epidemiological Methods and Etiologic Research, University of Bremen, National and Kapodistrian University of Athens (NKUA), Università degli Studi di Padova = University of Padua (Unipd), Imperial College London, Dublin Dental University Hospital, Trinity College [Dublin, Ireland], Cancer Registry of Norway, University of Glasgow, University of Aberdeen, Institut d'Investigació Biomèdica de Bellvitge [Barcelone] (IDIBELL), Di Credico, G., Polesel, J., Dal Maso, L., Pauli, F., Torelli, N., Luce, D., Radoi, L., Matsuo, K., Serraino, D., Brennan, P., Holcatova, I., Ahrens, W., Lagiou, P., Canova, C., Richiardi, L., Healy, C. M., Kjaerheim, K., Conway, D. I., Macfarlane, G. J., Thomson, P., Agudo, A., Znaor, A., Franceschi, S., Herrero, R., Toporcov, T. N., Moyses, R. A., Muscat, J., Negri, E., Vilensky, M., Fernandez, L., Curado, M. P., Menezes, A., Daudt, A. W., Koifman, R., Wunsch-Filho, V., Olshan, A. F., Zevallos, J. P., Sturgis, E. M., Li, G., Levi, F., Zhang, Z. -F., Morgenstern, H., Smith, E., Lazarus, P., La Vecchia, C., Garavello, W., Chen, C., Schwartz, S. M., Zheng, T., Vaughan, T. L., Kelsey, K., Mcclean, M., Benhamou, S., Hayes, R. B., Purdue, M. P., Gillison, M., Schantz, S., Yu, G. -P., Chuang, S. -C., Boffetta, P., Hashibe, M., Yuan-Chin, A. L., Edefonti, V., Di Credico, G, Polesel, J, Dal Maso, L, Pauli, F, Torelli, N, Luce, D, Radoi, L, Matsuo, K, Serraino, D, Brennan, P, Holcatova, I, Ahrens, W, Lagiou, P, Canova, C, Richiardi, L, Healy, C, Kjaerheim, K, Conway, D, Macfarlane, G, Thomson, P, Agudo, A, Znaor, A, Franceschi, S, Herrero, R, Toporcov, T, Moyses, R, Muscat, J, Negri, E, Vilensky, M, Fernandez, L, Curado, M, Menezes, A, Daudt, A, Koifman, R, Wunsch-Filho, V, Olshan, A, Zevallos, J, Sturgis, E, Li, G, Levi, F, Zhang, Z, Morgenstern, H, Smith, E, Lazarus, P, La Vecchia, C, Garavello, W, Chen, C, Schwartz, S, Zheng, T, Vaughan, T, Kelsey, K, Mcclean, M, Benhamou, S, Hayes, R, Purdue, M, Gillison, M, Schantz, S, Yu, G, Chuang, S, Boffetta, P, Hashibe, M, Yuan-Chin, A, and Edefonti, V

Subjects
Male, Cancer Research, Bivariate spline model, Time Factors, Diseases, Alcohol use disorder, Severity of Illness Index, Alcohol Use and Health, 0302 clinical medicine, Risk Factors, Laryngeal cancer, 80 and over, 2.2 Factors relating to the physical environment, Young adult, Head and neck cancer, Cancer, Aged, 80 and over, Mouth neoplasm, Oropharyngeal cancer, Head and Neck Neoplasm, Smoking, Confounding, Substance Abuse, Middle Aged, Oropharyngeal Neoplasms, Alcoholism, Oncology, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Public Health and Health Services, Mouth Neoplasms, Female, Case-Control Studie, Hypopharyngeal cancer, Human, Oropharyngeal Neoplasm, Adult, medicine.medical_specialty, Time Factor, Alcohol Drinking, Adolescent, Oncology and Carcinogenesis, Oral cavity cancer, Article, Young Adult, 03 medical and health sciences, Rare Diseases, Alcohol intensity, Internal medicine, Tobacco, medicine, Humans, Oncology & Carcinogenesis, Dental/Oral and Craniofacial Disease, Risk factor, Bivariate spline models, Alcohol duration, Laryngeal Neoplasms, Aged, Laryngeal Neoplasm, Tobacco Smoke and Health, business.industry, Risk Factor, Prevention, Case-control study, medicine.disease, Mouth Neoplasm, Risk factors, Case-Control Studies, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Digestive Diseases, business
Abstract

Background Alcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk. Methods Data from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking. Results For all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx). Conclusions Present results further encourage the reduction of alcohol intensity to mitigate HNC risk.

Published
2020

19. Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach

Author

Philip Lazarus, Claire M. Healy, Richard B. Hayes, Rolando Herrero, Elaine M. Smith, Stefania Boccia, Leonardo F. Boaventura Rios, Paolo Boffetta, Dana Mates, Jerry Polesel, Marta Vilensky, Jose P. Zevallos, Diego Serraino, Gypsyamber D'Souza, Joshua E. Muscat, Kirsten B. Moysich, Yuan Chin Amy Lee, Mark P. Purdue, Carlo La Vecchia, Heribert Ramroth, Thomas L. Vaughan, Peter Thomson, Karl T. Kelsey, Nicola Torelli, Wolfgang Ahrens, Hermann Brenner, Lorenzo Richiardi, Victor Wünsch-Filho, Kristina Kjærheim, Beata Swiatkowska, Keitaro Matsuo, Fabio Levi, Erich M. Sturgis, Eva Negri, Lorenzo Simonato, Danièle Luce, Guo Pei Yu, Chu Chen, Pagona Lagiou, Silvia Franceschi, Andrew F. Olshan, Alexander W. Daudt, Antonio Agudo, Maria Paula Curado, Peter Rudnai, Tatiana V. Macfarlane, Zuo-Feng Zhang, Mia Hashibe, Paul Brennan, Tatiana Natasha Toporcov, Stimson P. Schantz, Maura L. Gillison, Isabelle Stücker, Tongzhang Zheng, Shu Chun Chuang, Oxana Shangina, Eleonora Fabianova, Hal Morgenstern, David I. Conway, Valeria Edefonti, Cristina Bosetti, Ariana Znaor, Leticia Fernandez, Michael D. McClean, Luigino Dal Maso, Neil D. Gross, Stephen M. Schwartz, Ivana Holcatova, Guojun Li, Ana M. B. Menezes, Francesco Pauli, Gioia Di Credico, Deborah M. Winn, Rosalina Jorge Koifman, Gwenn Menvielle, Gabriella Cadoni, Werner Garavello, Jolanda Lissowska, Università degli Studi di Milano [Milano] (UNIMI), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), University of Glasgow, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), TW001500, National Institutes of Health, P30ES010126, National Institute of Environmental Health Sciences, Italian Ministry of Education, Università degli Studi di Milano, Jonsson Comprehensive Cancer Center, International Union Against Cancer, Fondo para la Investigacion Cientifica y Tecnologica Argentina, Institut Hospital del Mar d’Investigacions Mediquès (IMIM), Fundação de Amparo à Pesquisa no Estado de São Paulo, Spanish Government, European Community, Ministry of Science, Research and Arts Baden-Wurttemberg, German Ministry of Education and Research, Scientific Research grant from the Ministry of Education, Science, Sports, Culture and Technology of Japan, Labor and Welfare of Japan, Italian Foundation for Cancer Research, Di Credico G., Edefonti V., Polesel J., Pauli F., Torelli N., Serraino D., Negri E., Luce D., Stucker I., Matsuo K., Brennan P., Vilensky M., Fernandez L., Curado M.P., Menezes A., Daudt A.W., Koifman R., Wunsch-Filho V., Holcatova I., Ahrens W., Lagiou P., Simonato L., Richiardi L., Healy C., Kjaerheim K., Conway D.I., Macfarlane T.V., Thomson P., Agudo A., Znaor A., Boaventura Rios L.F., Toporcov T.N., Franceschi S., Herrero R., Muscat J., Olshan A.F., Zevallos J.P., La Vecchia C., Winn D.M., Sturgis E.M., Li G., Fabianova E., Lissowska J., Mates D., Rudnai P., Shangina O., Swiatkowska B., Moysich K., Zhang Z.-F., Morgenstern H., Levi F., Smith E., Lazarus P., Bosetti C., Garavello W., Kelsey K., McClean M., Ramroth H., Chen C., Schwartz S.M., Vaughan T.L., Zheng T., Menvielle G., Boccia S., Cadoni G., Hayes R.B., Purdue M., Gillison M., Schantz S., Yu G.-P., Brenner H., D'Souza G., Gross N.D., Chuang S.-C., Boffetta P., Hashibe M., Lee Y.-C.A., Dal Maso L., Di Credico, G, Edefonti, V, Polesel, J, Pauli, F, Torelli, N, Serraino, D, Negri, E, Luce, D, Stucker, I, Matsuo, K, Brennan, P, Vilensky, M, Fernandez, L, Curado, M, Menezes, A, Daudt, A, Koifman, R, Wunsch-Filho, V, Holcatova, I, Ahrens, W, Lagiou, P, Simonato, L, Richiardi, L, Healy, C, Kjaerheim, K, Conway, D, Macfarlane, T, Thomson, P, Agudo, A, Znaor, A, Boaventura Rios, L, Toporcov, T, Franceschi, S, Herrero, R, Muscat, J, Olshan, A, Zevallos, J, La Vecchia, C, Winn, D, Sturgis, E, Li, G, Fabianova, E, Lissowska, J, Mates, D, Rudnai, P, Shangina, O, Swiatkowska, B, Moysich, K, Zhang, Z, Morgenstern, H, Levi, F, Smith, E, Lazarus, P, Bosetti, C, Garavello, W, Kelsey, K, Mcclean, M, Ramroth, H, Chen, C, Schwartz, S, Vaughan, T, Zheng, T, Menvielle, G, Boccia, S, Cadoni, G, Hayes, R, Purdue, M, Gillison, M, Schantz, S, Yu, G, Brenner, H, D'Souza, G, Gross, N, Chuang, S, Boffetta, P, Hashibe, M, Lee, Y, Dal Maso, L, Di Credico, Gioia, Edefonti, Valeria, Polesel, Jerry, Pauli, Francesco, Torelli, Nicola, Serraino, Diego, Negri, Eva, Luce, Daniele, Stucker, Isabelle, Matsuo, Keitaro, Brennan, Paul, Vilensky, Marta, Fernandez, Leticia, Curado, Maria Paula, Menezes, Ana, Daudt, Alexander W., Koifman, Rosalina, Wunsch-Filho, Victor, Holcatova, Ivana, Ahrens, Wolfgang, Lagiou, Pagona, Simonato, Lorenzo, Richiardi, Lorenzo, Healy, Claire, Kjaerheim, Kristina, Conway, David I., Macfarlane, Tatiana V., Thomson, Peter, Agudo, Antonio, Znaor, Ariana, Boaventura Rios, Leonardo F., Toporcov, Tatiana N., Franceschi, Silvia, Herrero, Rolando, Muscat, Joshua, Olshan, Andrew F., Zevallos, Jose P., La Vecchia, Carlo, Winn, Deborah M., Sturgis, Erich M., Li, Guojun, Fabianova, Eleonora, Lissowska, Jolanda, Mates, Dana, Rudnai, Peter, Shangina, Oxana, Swiatkowska, Beata, Moysich, Kirsten, Zhang, Zuo-Feng, Morgenstern, Hal, Levi, Fabio, Smith, Elaine, Lazarus, Philip, Bosetti, Cristina, Garavello, Werner, Kelsey, Karl, Mcclean, Michael, Ramroth, Heribert, Chen, Chu, Schwartz, Stephen M., Vaughan, Thomas L., Zheng, Tongzhang, Menvielle, Gwenn, Boccia, Stefania, Cadoni, Gabriella, Hayes, Richard B., Purdue, Mark, Gillison, Maura, Schantz, Stimson, Yu, Guo-Pei, Brenner, Hermann, D'Souza, Gypsyamber, Gross, Neil D., Chuang, Shu-Chun, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, Dal Maso, Luigino, Università degli Studi di Milano = University of Milan (UNIMI), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)

Subjects
Male, Oral cavity and pharyngeal cancers, Cancer Research, Bivariate spline model, medicine.medical_treatment, Logistic regression, Substance Misuse, 0302 clinical medicine, Risk Factors, Laryngeal cancer, 80 and over, 2.2 Factors relating to the physical environment, Aetiology, 030223 otorhinolaryngology, Head and neck cancer, Cancer, Aged, 80 and over, Confounding, Middle Aged, 3. Good health, Oncology, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Bivariate spline models, Cigarette smoking duration, Cigarette smoking intensity, Public Health and Health Services, Female, Oral Surgery, Adult, INHANCE, Oncology and Carcinogenesis, [SDV.CAN]Life Sciences [q-bio]/Cancer, Bivariate analysis, Cigarette Smoking, 03 medical and health sciences, Rare Diseases, Clinical Research, Tobacco, medicine, Humans, Oncology & Carcinogenesis, Dental/Oral and Craniofacial Disease, Aged, Settore MED/06 - ONCOLOGIA MEDICA, Tobacco Smoke and Health, business.industry, Prevention, Case-control study, Odds ratio, medicine.disease, Former Smoker, Good Health and Well Being, Case-Control Studies, Dentistry, Smoking cessation, business, Demography
Abstract

Objectives: \ud This study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures.\ud \ud Materials and Methods: \ud We pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework.\ud \ud Results: \ud For oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of ∼20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs >20 were found for current smokers of ≥20 cigarettes/day for ≥30 years. In former smokers who quit ≥10 years ago, the ORs were approximately halved for OCP cancers, and ∼1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers.\ud \ud Conclusion: \ud Referring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies.

Published
2019

20. Dietary glycaemic index, glycaemic load and head and neck cancer risk: a pooled analysis in an international consortium

Author

Valeria Edefonti, Stephen M. Schwartz, Livia S. A. Augustin, Hal Morgenstern, Maria Parpinel, Chu Chen, Werner Garavello, Carlo La Vecchia, Guo Pei Yu, Paolo Boffetta, Jose P. Zevallos, Mia Hashibe, Stimson P. Schantz, Michael D. McClean, Fabio Levi, Diego Serraino, Chun Pin Chang, Federica Turati, Karl T. Kelsey, Yuan Chin Amy Lee, Zuo-Feng Zhang, Andrew F. Olshan, Chang, C, La Vecchia, C, Serraino, D, Olshan, A, Zevallos, J, Morgenstern, H, Levi, F, Garavello, W, Kelsey, K, Mcclean, M, Chen, C, Schwartz, S, Schantz, S, Yu, G, Boffetta, P, Hashibe, M, Lee, Y, Parpinel, M, Augustin, L, Turati, F, Zhang, Z, and Edefonti, V

Subjects
Oncology, Male, Cancer Research, medicine.medical_specialty, Epidemiology, Oncology and Carcinogenesis, Brief Communication, Cancer prevention, 03 medical and health sciences, 0302 clinical medicine, Rare Diseases, Cancer epidemiology, Internal medicine, Surveys and Questionnaires, Epidemiology of cancer, medicine, Humans, 030212 general & internal medicine, Oncology & Carcinogenesis, Dental/Oral and Craniofacial Disease, Head and neck cancer, Cancer, business.industry, Prevention, Case-control study, Glycemic Load, Dietary glycaemic index, glycaemic load, head and neck cancer, risk, Odds ratio, medicine.disease, Confidence interval, Risk factors, Glycemic Index, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Case-Control Studies, Public Health and Health Services, Female, business, Digestive Diseases, human activities
Abstract

High dietary glycaemic index (GI) and glycaemic load (GL) may increase cancer risk. However, limited information was available on GI and/or GL and head and neck cancer (HNC) risk. We conducted a pooled analysis on 8 case-control studies (4081 HNC cases; 7407 controls) from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. We estimated the odds ratios (ORs) and 95% confidence intervals (CIs) of HNC, and its subsites, from fixed- or mixed-effects logistic models including centre-specific quartiles of GI or GL. GI, but not GL, had a weak positive association with HNC (ORQ4 vs. Q1 = 1.16; 95% CI = 1.02–1.31). In subsites, we found a positive association between GI and laryngeal cancer (ORQ4 vs. Q1 = 1.60; 95% CI = 1.30–1.96) and an inverse association between GL and oropharyngeal cancer (ORQ4 vs. Q1 = 0.78; 95% CI = 0.63–0.97). This pooled analysis indicates a modest positive association between GI and HNC, mainly driven by laryngeal cancer.

Published
2020

21. Vitamin E intake from natural sources and head and neck cancer risk: a pooled analysis in the International Head and Neck Cancer Epidemiology consortium

Author

Diego Serraino, Hal Morgenstern, Keitaro Matsuo, Federica Turati, Cristina Bosetti, Monica Ferraroni, Paolo Boffetta, Jose P. Zevallos, Valeria Edefonti, Stimson P. Schantz, Fabio Levi, Andrew F. Olshan, Guo-Pei Yu, C. La Vecchia, Maria Parpinel, Deborah M. Winn, Yuan Chin Amy Lee, Karl T. Kelsey, Shu Chun Chuang, Mia Hashibe, Zuo-Feng Zhang, Michael D. McClean, K. Moysich, Adriano Decarli, Edefonti, V., Hashibe, M., Parpinel, M., Ferraroni, M., Turati, F., Serraino, D., Matsuo, K., Olshan, A.F., Zevallos, J.P., Winn, D.M., Moysich, K., Zhang, Z.-F., Morgenstern, H., Levi, F., Kelsey, K., McClean, M., Bosetti, C., Schantz, S., Yu, G.-P., Boffetta, P., Chuang, S.-C., A Lee, Y.-C., La Vecchia, C., and Decarli, A.

Subjects
Oncology, Adult, Male, Cancer Research, medicine.medical_specialty, INHANCE, Colorectal cancer, Epidemiology, medicine.medical_treatment, education, Oncology and Carcinogenesis, oral and pharyngeal cancer, vitamin E, Prostate cancer, Breast cancer, Rare Diseases, Internal medicine, Complementary and Integrative Health, medicine, Humans, Vitamin E, Oncology & Carcinogenesis, Dental/Oral and Craniofacial Disease, Cancer, Nutrition, Aged, Cervical cancer, business.industry, Prevention, Head and neck cancer, Female, Head and Neck Neoplasms, medicine.disease, 3. Good health, Vitamin - head and neck cancer risk, Public Health and Health Services, laryngeal cancer, head and neck cancer, Skin cancer, business, Digestive Diseases
Abstract

Evidence for the possible effect of vitamin E on head and neck cancers (HNCs) is limited.Methods:We used individual-level pooled data from 10 case-control studies (5959 cases and 12 248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium to assess the association between vitamin E intake from natural sources and cancer of the oral cavity/pharynx and larynx. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression models applied to quintile categories of nonalcohol energy-adjusted vitamin E intake.Results:Intake of vitamin E was inversely related to oral/pharyngeal cancer (OR for the fifth vs the first quintile category=0.59, 95% CI: 0.49-0.71; P for trend

Published
2015

22. Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries

Author

Conway, David I., Brenner, Darren R., McMahon, Alex D., Macpherson, Lorna M.D., Agudo, Antonio, Ahrens, Wolfgang, Bosetti, Cristina, Brenner, Hermann, Castellsague, Xavier, Chen, Chu, Curado, Maria Paula, Curioni, Otávio A., Dal Maso, Luigino, Daudt, Alexander W., de Gois Filho, José F., D'Souza, Gypsyamber, Edefonti, Valeria, Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Gillison, Maura, Hayes, Richard B., Healy, Claire M., Herrero, Rolando, Holcatova, Ivana, Jayaprakash, Vijayvel, Kelsey, Karl, Kjaerheim, Kristina, Koifman, Sergio, La Vecchia, Carlo, Lagiou, Pagona, Lazarus, Philip, Levi, Fabio, Lissowska, Jolanta, Luce, Daniele, Macfarlane, Tatiana V., Mates, Dana, Matos, Elena, McClean, Michael, Menezes, Ana M., Menvielle, Gwenn, Merletti, Franco, Morgenstern, Hal, Moysich, Kirsten, Müller, Heiko, Muscat, Joshua, Olshan, Andrew F., Purdue, Mark P., Ramroth, Heribert, Richiardi, Lorenzo, Rudnai, Peter, Schantz, Stimson, Schwartz, Stephen M., Shangina, Oxana, Simonato, Lorenzo, Smith, Elaine, Stucker, Isabelle, Sturgis, Erich M., Szeszenia-Dabrowska, Neonila, Talamini, Renato, Thomson, Peter, Vaughan, Thomas L., Wei, Qingyi, Winn, Deborah M., Wunsch-Filho, Victor, Yu, Guo-Pei, Zhang, Zuo-Feng, Zheng, Tongzhang, Znaor, Ariana, Boffetta, Paolo, Chuang, Shu-Chun, Ghodrat, Marianoosh, Amy Lee, Yuan-Chin, Hashibe, Mia, Brennan, Paul, International Prevention Research Institute (IPRI), Conway, D.I., Brenner, D.R., McMahon, A.D., Macpherson, L.M.D., Agudo, A., Ahrens, W., Bosetti, C., Brenner, H., Castellsague, X., Chen, C., Curado, M.P., Curioni, O.A., Maso, L.D., Daudt, A.W., De Gois Filho, J.F., D'Souza, G., Edefonti, V., Fabianova, E., Fernandez, L., Franceschi, S., Gillison, M., Hayes, R.B., Healy, C.M., Herrero, R., Holcatova, I., Jayaprakash, V., Kelsey, K., Kjaerheim, K., Koifman, S., La Vecchia, C., Lagiou, P., Lazarus, P., Levi, F., Lissowska, J., Luce, D., Macfarlane, T.V., Mates, D., Matos, E., McClean, M., Menezes, A.M., Menvielle, G., Merletti, F., Morgenstern, H., Moysich, K., Müller, H., Muscat, J., Olshan, A.F., Purdue, M.P., Ramroth, H., Richiardi, L., Rudnai, P., Schantz, S., Schwartz, S.M., Shangina, O., Simonato, L., Smith, E., Stucker, I., Sturgis, E.M., Szeszenia-Dabrowska, N., Talamini, R., Thomson, P., Vaughan, T.L., Wei, Q., Winn, D.M., Wunsch-Filho, V., Yu, G.-P., Zhang, Z.-F., Zheng, T., Znaor, A., Boffetta, P., Chuang, S.-C., Ghodrat, M., Lee, Y.-C.A., Hashibe, M., and Brennan, P.

Subjects
Male, epidemiology, head and neck cancer, socioeconomic inequalities, Cancer Research, Alcohol Drinking/*adverse effects Case-Control Studies *Education Female Follow-Up Studies Global Health Head and Neck Neoplasms/*etiology Humans Income/*statistics & numerical data Male Meta-Analysis as Topic Middle Aged Prognosis Risk Factors Smoking/*adverse effects Socioeconomic Factors epidemiology head and neck cancer socioeconomic inequalities, Alcohol Drinking, Epidemiology, Head and neck cancer, Socioeconomic inequalities, Case-Control Studies, Female, Follow-Up Studies, Global Health, Head and Neck Neoplasms, Humans, Income, Meta-Analysis as Topic, Middle Aged, Prognosis, Risk Factors, Smoking, Socioeconomic Factors, Education, Oncology, Medicine (all), Article, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract

Conway, David I Brenner, Darren R McMahon, Alex D Macpherson, Lorna M D Agudo, Antonio Ahrens, Wolfgang Bosetti, Cristina Brenner, Hermann Castellsague, Xavier Chen, Chu Curado, Maria Paula Curioni, Otavio A Dal Maso, Luigino Daudt, Alexander W de Gois Filho, Jose F D'Souza, Gypsyamber Edefonti, Valeria Fabianova, Eleonora Fernandez, Leticia Franceschi, Silvia Gillison, Maura Hayes, Richard B Healy, Claire M Herrero, Rolando Holcatova, Ivana Jayaprakash, Vijayvel Kelsey, Karl Kjaerheim, Kristina Koifman, Sergio La Vecchia, Carlo Lagiou, Pagona Lazarus, Philip Levi, Fabio Lissowska, Jolanta Luce, Daniele Macfarlane, Tatiana V Mates, Dana Matos, Elena McClean, Michael Menezes, Ana M Menvielle, Gwenn Merletti, Franco Morgenstern, Hal Moysich, Kirsten Muller, Heiko Muscat, Joshua Olshan, Andrew F Purdue, Mark P Ramroth, Heribert Richiardi, Lorenzo Rudnai, Peter Schantz, Stimson Schwartz, Stephen M Shangina, Oxana Simonato, Lorenzo Smith, Elaine Stucker, Isabelle Sturgis, Erich M Szeszenia-Dabrowska, Neonila Talamini, Renato Thomson, Peter Vaughan, Thomas L Wei, Qingyi Winn, Deborah M Wunsch-Filho, Victor Yu, Guo-Pei Zhang, Zuo-Feng Zheng, Tongzhang Znaor, Ariana Boffetta, Paolo Chuang, Shu-Chun Ghodrat, Marianoosh Amy Lee, Yuan-Chin Hashibe, Mia Brennan, Paul eng DE016631/DE/NIDCR NIH HHS/ K07CA104231/CA/NCI NIH HHS/ NIDCR R01DE11979/DE/NIDCR NIH HHS/ NIDCRR01DE13110/DE/NIDCR NIH HHS/ NIH FIRCA TW01500/TW/FIC NIH HHS/ P01CA068384/CA/NCI NIH HHS/ P30ES010126/ES/NIEHS NIH HHS/ P50CA090388/CA/NCI NIH HHS/ R01 CA078609/CA/NCI NIH HHS/ R01 CA100679/CA/NCI NIH HHS/ R01CA030022/CA/NCI NIH HHS/ R01CA048996/CA/NCI NIH HHS/ R01CA051845/CA/NCI NIH HHS/ R01CA061188/CA/NCI NIH HHS/ R01CA078609/CA/NCI NIH HHS/ R01CA100264/CA/NCI NIH HHS/ R01CA100679/CA/NCI NIH HHS/ R01CA90731/CA/NCI NIH HHS/ R01DA011386/DA/NIDA NIH HHS/ R01DA026815/DA/NIDA NIH HHS/ R01DE012609/DE/NIDCR NIH HHS/ R01DE013158/DE/NIDCR NIH HHS/ R01ES011740/ES/NIEHS NIH HHS/ R03CA077954/CA/NCI NIH HHS/ R03CA113157/CA/NCI NIH HHS/ R03DE016611/DE/NIDCR NIH HHS/ R21ES011667/ES/NIEHS NIH HHS/ T32CA009142/CA/NCI NIH HHS/ U01CA096134/CA/NCI NIH HHS/ Intramural NIH HHS/ Comparative Study Multicenter Study Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. 2014/07/06 06:00 Int J Cancer. 2015 Mar 1;136(5):1125-39. doi: 10.1002/ijc.29063. Epub 2014 Aug 23.; International audience; Low socioeconomic status has been reported to be associated with head and neck cancer risk. However, previous studies have been too small to examine the associations by cancer subsite, age, sex, global region and calendar time and to explain the association in terms of behavioral risk factors. Individual participant data of 23,964 cases with head and neck cancer and 31,954 controls from 31 studies in 27 countries pooled with random effects models. Overall, low education was associated with an increased risk of head and neck cancer (OR = 2.50; 95% CI = 2.02 - 3.09). Overall one-third of the increased risk was not explained by differences in the distribution of cigarette smoking and alcohol behaviors; and it remained elevated among never users of tobacco and nondrinkers (OR = 1.61; 95% CI = 1.13 - 2.31). More of the estimated education effect was not explained by cigarette smoking and alcohol behaviors: in women than in men, in older than younger groups, in the oropharynx than in other sites, in South/Central America than in Europe/North America and was strongest in countries with greater income inequality. Similar findings were observed for the estimated effect of low versus high household income. The lowest levels of income and educational attainment were associated with more than 2-fold increased risk of head and neck cancer, which is not entirely explained by differences in the distributions of behavioral risk factors for these cancers and which varies across cancer sites, sexes, countries and country income inequality levels.

Published
2015

23. Carotenoid intake and head and neck cancer: a pooled analysis in the International Head and Neck Cancer Epidemiology Consortium

Author

Adriano Decarli, Monica Ferraroni, Guo Pei Yu, Mia Hashibe, Hal Morgenstern, Stefania Boccia, Michael D. McClean, Maria Parpinel, Emanuele Leoncini, Keitaro Matsuo, Valeria Edefonti, Carlo La Vecchia, Shu Chun Chuang, Deborah M. Winn, Diego Serraino, Stimson P. Schantz, Fabio Levi, Paolo Boffetta, Jose P. Zevallos, Cristina Bosetti, Kirsten B. Moysich, Zuo-Feng Zhang, Karl T. Kelsey, Yuan Chin Amy Lee, Andrew F. Olshan, Gabriella Cadoni, Leoncini, E., Edefonti, V., Hashibe, M., Parpinel, M., Cadoni, G., Ferraroni, M., Serraino, D., Matsuo, K., Olshan, A.F., Zevallos, J.P., Winn, D.M., Moysich, K., Zhang, Z.-F., Morgenstern, H., Levi, F., Kelsey, K., McClean, M., Bosetti, C., Schantz, S., Yu, G.-P., Boffetta, P., Lee, Y.-C.A., Chuang, S.-C., Decarli, A., La Vecchia, C., and Boccia, S.

Subjects
0301 basic medicine, Epidemiology, Gastroenterology, Antioxidants, Oral and gastrointestinal, chemistry.chemical_compound, 0302 clinical medicine, Japan, 80 and over, Head and neck cancer, Carotenoid, Cancer, chemistry.chemical_classification, food and beverages, Middle Aged, Lycopene, carotenoid, Europe, Zeaxanthin, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Public Health and Health Services, Female, Settore MED/31 - OTORINOLARINGOIATRIA, Carotenoid intake - head and neck cancer, Adult, medicine.medical_specialty, Carotenoids, Diet, Nutrients, 03 medical and health sciences, Rare Diseases, head and neck neoplasms, Internal medicine, medicine, Humans, Dental/Oral and Craniofacial Disease, Settore MED/42 - IGIENE GENERALE E APPLICATA, Aged, Nutrition, Squamous Cell Carcinoma of Head and Neck, business.industry, Prevention, Carcinoma, Case-control study, Odds ratio, medicine.disease, United States, Surgery, Epidemiologic Studies, Good Health and Well Being, 030104 developmental biology, Squamous Cell, chemistry, Case-Control Studies, head and neck cancer, Digestive Diseases, business
Abstract

Food and nutrition play an important role in head and neck cancer (HNC) etiology; however, the role of carotenoids remains largely undefined. We explored the relation of HNC risk with the intake of carotenoids within the International Head and Neck Cancer Epidemiology Consortium. We pooled individual-level data from 10 case-control studies conducted in Europe, North America, and Japan. The analysis included 18,207 subjects (4414 with oral and pharyngeal cancer, 1545 with laryngeal cancer, and 12,248 controls), categorized by quintiles of carotenoid intake from natural sources. Comparing the highest with the lowest quintile, the risk reduction associated with total carotenoid intake was 39% (95% CI 29-47%) for oral/pharyngeal cancer and 39% (95% CI 24-50%) for laryngeal cancer. Intakes of β-carotene equivalents, β-cryptoxanthin, lycopene, and lutein plus zeaxanthin were associated with at least 18% reduction in the rate of oral and pharyngeal cancer (95% CI 6-29%) and 17% reduction in the rate of laryngeal cancer (95% CI 0-32%). The overall protective effect of carotenoids on HNC was stronger for subjects reporting greater alcohol consumption (p&nbsp

Published
2015

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