1. [HPV DNA genotyping: A study of anogenital, head and neck and skin cancers in a population from west Algerian. HPV detection in different cancers from an Algerian population].
- Author
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Nahet A, Boublenza L, Hassaine H, Masdoua N, Prétet JL, Belglaiaa E, and Mougin C
- Subjects
- Adult, Aged, Aged, 80 and over, Algeria, Female, Genotype, Human papillomavirus 16 genetics, Human papillomavirus 16 isolation & purification, Human papillomavirus 18 genetics, Human papillomavirus 18 isolation & purification, Humans, Laryngeal Neoplasms virology, Male, Middle Aged, Papillomaviridae classification, Papillomaviridae isolation & purification, Tonsillar Neoplasms virology, Uterine Cervical Neoplasms virology, Vaginal Neoplasms virology, Vulvar Neoplasms virology, Anus Neoplasms virology, DNA, Viral isolation & purification, Genital Neoplasms, Female virology, Head and Neck Neoplasms virology, Papillomaviridae genetics, Skin Neoplasms virology
- Abstract
Objectives: To investigate the prevalence of human papillomaviruses (HPV) in cancers located at different sites in patients from west Algerian and collected between 2010 and 2014., Material and Methods: Extracted DNA from archival formaldehyde-fixed and paraffin-embedded tissues was provided from 39 anogenital cancers, 10 head and neck cancers and 36 skin cancers. The viral DNA was detected using the INNO-LiPA HPV Genotyping Extra(®) kit., Results: The prevalence of HPV was 100% in cervical cancers, 40% in vaginal cancers, 17% in vulvar cancers, 33% in anal cancers, 0% in tonsil and larynx cancers and 6.4% in skin squamous cell carcinoma. In cervical cancers, the most prevalent genotypes were HPV16 (52%) and HPV18 (12%) as single infection., Conclusion: The overall results agree partially with literature. Extensive research is necessary to promote HPV vaccine to reduce in particular the burden of cervical cancer in Algeria., (Copyright © 2016 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.)
- Published
- 2016
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