18 results on '"Patel, Snehal G."'
Search Results
2. Intraoperative and postanesthesia care unit fluid administration as risk factors for postoperative complications in patients with head and neck cancer undergoing free tissue transfer.
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Dooley, Bryan J., Karassawa Zanoni, Daniella, Mcgill, Marlena R., Awad, Mahmoud I., Shah, Jatin P., Wong, Richard J., Broad, Clara, Mehrara, Babak J., Ganly, Ian, and Patel, Snehal G.
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HEAD & neck cancer ,INTRAOPERATIVE care ,SURGICAL complications ,NECK dissection ,FREE flaps ,SQUAMOUS cell carcinoma ,SURGICAL flaps - Abstract
Background: This study aims to evaluate the impact of perioperative fluid administration, defined as fluid delivered intraoperatively and in the postanesthesia care unit, on postoperative outcomes. Methods: Medical records of 102 patients with oral cavity squamous cell carcinoma undergoing free flap reconstruction between January 2011 and December 2015 were reviewed. The primary endpoint was development of a postoperative complication according to the Clavien‐Dindo classification. Perioperative factors recorded were Washington University Head and Neck Comorbidity Index, operating time, vasopressor use, blood loss, intraoperative fluid, and perioperative fluid. Results: Greater perioperative fluid administration was independently associated with surgical complications, flap complications, overall incidence of any complication, and increased length of stay. Greater intraoperative fluid administration was independently associated with higher rates of surgical complications. Intraoperative delivery of vasopressors was not associated with flap or surgical complications. Conclusion: Receiving less perioperative fluid was associated with fewer complications and decreased length of stay. [ABSTRACT FROM AUTHOR]
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- 2020
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3. Depth of invasion alone as an indication for postoperative radiotherapy in small oral squamous cell carcinomas: An International Collaborative Study.
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Clark, Jonathan R., Ebrahimi, Ardalan, Agarwal, Jai Prakash, Kowalski, Luiz P., Köhler, Hugo F., Kreppel, Matthias, Cernea, Claudio R., Brandao, Jason, Bachar, Gideon, Villaret, Andrea Bolzoni, Fliss, Dan M., Fridman, Eran, Robbins, Kevin Thomas, Shah, Jatin P., Patel, Snehal G., Gil, Ziv, Amit, Moran, Yen, Tzu‐Chen, Liao, Chun‐ta, and Chaturvedi, Pankaj
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RADIOTHERAPY ,SQUAMOUS cell carcinoma ,CLINICAL indications ,HEAD & neck cancer ,CANCER invasiveness - Abstract
Background: We aimed to investigate whether depth of invasion (DOI) should be an independent indication for postoperative radiotherapy (PORT) in small oral squamous cell carcinomas (SCC). Methods: Retrospective analysis of DOI (<5, 5 to <10, ≥10 mm) and disease‐specific survival (DSS) in a multi‐institutional international cohort of 1409 patients with oral SCC ≤4 cm in size treated between 1990‐2011. Results: In patients without other adverse factors (nodal metastases; close [<5 mm] or involved margins), there was no association between DOI and DSS, with an excellent prognosis irrespective of depth. In the absence of PORT, the 5‐year disease‐specific mortality was 10% with DOI ≥10 mm, 8% with DOI 5‐10 mm, and 6% with DOI <5 mm (P = .169), yielding an absolute risk difference of only 4%. Conclusion: The deterioration in prognosis with increasing DOI largely reflects an association with other adverse features. In the absence of these, depth alone should not be an indication for PORT outside a clinical trial. [ABSTRACT FROM AUTHOR]
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- 2019
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4. Leveraging patient-reported outcomes data to inform oncology clinical decision making: Introducing the FACE-Q Head and Neck Cancer Module.
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Cracchiolo, Jennifer R., Klassen, Anne F., Young‐Afat, Danny A., Albornoz, Claudia R., Cano, Stefan J., Patel, Snehal G., Pusic, Andrea L., Matros, Evan, and Young-Afat, Danny A
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HEAD & neck cancer ,DECISION making - Abstract
Background: Existing patient-reported outcome measures (PROMs) used to assess patients with head and neck cancer have methodologic and content deficiencies. Herein, the development of a PROM that meets a range of clinical and research needs across head and neck oncology is described.Methods: After development of the conceptual framework, which involved a literature review, semistructured patient interviews, and expert input, patients with head and neck cancer who were treated at Memorial Sloan Kettering Cancer Center were recruited by their surgeon. The FACE-Q Head and Neck Cancer Module was completed by patients in the clinic or was sent by mail. Rasch measurement theory analysis was used for item selection for final scale development and to examine reliability and validity. Scale scores for surgical defect and adjuvant therapy were compared with the cohort average to assess clinical applicability.Results: The sample consisted of 219 patients who completed the draft scales. Fourteen independently functioning scales were analyzed. Item fit was good for all 102 items, and all items had ordered thresholds. Scale reliability was acceptable (person separation index was >0.75 for all scales; Cronbach α values were >.87 for all scales; test-retest ranged from 0.86 to 0.96). The scales performed well in a clinically predictable way, demonstrating functional and psychosocial differences across disease sites and with adjuvant therapy.Conclusions: The scales forming the FACE-Q Head and Neck Cancer Module were found to be clinically relevant and scientifically sound. This new PROM now is validated and ready for use in research and clinical care. [ABSTRACT FROM AUTHOR]- Published
- 2019
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5. Head and Neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual.
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Lydiatt, William M., Patel, Snehal G., O'Sullivan, Brian, Brandwein, Margaret S., Ridge, John A., Migliacci, Jocelyn C., Loomis, Ashley M., and Shah, Jatin P.
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HEAD & neck cancer ,MELANOMA ,MERKEL cell carcinoma ,LYMPH nodes - Abstract
Answer questions and earn CME/CNE The recently released eighth edition of the American Joint Committee on Cancer (AJCC) Staging Manual, Head and Neck Section, introduces significant modifications from the prior seventh edition. This article details several of the most significant modifications, and the rationale for the revisions, to alert the reader to evolution of the field. The most significant update creates a separate staging algorithm for high-risk human papillomavirus-associated cancer of the oropharynx, distinguishing it from oropharyngeal cancer with other causes. Other modifications include: the reorganizing of skin cancer (other than melanoma and Merkel cell carcinoma) from a general chapter for the entire body to a head and neck-specific cutaneous malignancies chapter; division of cancer of the pharynx into 3 separate chapters; changes to the tumor (T) categories for oral cavity, skin, and nasopharynx; and the addition of extranodal cancer extension to lymph node category (N) in all but the viral-related cancers and mucosal melanoma. The Head and Neck Task Force worked with colleagues around the world to derive a staging system that reflects ongoing changes in head and neck oncology; it remains user friendly and consistent with the traditional tumor, lymph node, metastasis (TNM) staging paradigm. CA Cancer J Clin 2017;67:122-137. © 2017 American Cancer Society. [ABSTRACT FROM AUTHOR]
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- 2017
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6. Accuracy of administrative and clinical registry data in reporting postoperative complications after surgery for oral cavity squamous cell carcinoma.
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Awad, Mahmoud I., Shuman, Andrew G., Montero, Pablo H., Palmer, Frank L., Shah, Jatin P., and Patel, Snehal G.
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DENTAL caries ,SURGICAL complications ,SQUAMOUS cell carcinoma ,MEDICAL records ,HEAD & neck cancer - Abstract
Background The purpose of this study was to describe and compare how postoperative complications after oral cavity squamous cell carcinoma (SCC) surgery are reported in medical records, institutional billing claims, and national clinical registries. Methods The medical records of 355 previously untreated patients who underwent surgery for oral cavity SCC at our institution were retrospectively reviewed for postoperative complications. Information was compared with claims and National Surgical Quality Improvement Program (NSQIP) data. Results We identified 219 patients (62%) experiencing 544 complications (10% major). Billing claims identified 29% of these patients, 36% of overall complications, and 98% of major complications. Of overlapping patients, NSQIP identified 27% of patients, 33% of overall complications, and 100% of major complications noted on chart abstraction. Conclusion The incidence of minor postoperative complications after oral cavity SCC surgery is relatively high. Both claims data and NSQIP accurately recorded major complications, but were suboptimal compared to chart abstraction in capturing minor complications. © 2014 Wiley Periodicals, Inc. Head Neck 37: 851-861, 2015 [ABSTRACT FROM AUTHOR]
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- 2015
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7. Optimizing perioperative management of geriatric patients with head and neck cancer.
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Shuman, Andrew G., Patel, Snehal G., Shah, Jatin P., and Korc–Grodzicki, Beatriz
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HEAD & neck cancer treatment ,CANCER patient care ,MEDICAL humanities ,ONCOLOGIC surgery - Abstract
ABSTRACT Given emerging demographic trends, many more elderly patients are being diagnosed with head and neck cancers. The surgical care paradigm for this cohort of patients must take into account specific challenges inherent to geriatric perioperative management. This article attempts to summarize the existing body of literature relevant to the geriatric head and neck cancer population, and to extrapolate relevant data from geriatric perioperative medicine in order to better understand and guide management decisions. The involvement of geriatricians and of patients' primary care providers may be invaluable in assisting in complex perioperative decision-making and in participating in longitudinal management. Preoperative risk stratification and assessment of medical, social, and functional variables are critical for appropriate decision-making in this challenging patient population. © 2013 Wiley Periodicals, Inc. Head Neck 36: 743-749, 2014 [ABSTRACT FROM AUTHOR]
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- 2014
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8. Nomograms for preoperative prediction of prognosis in patients with oral cavity squamous cell carcinoma.
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Montero, Pablo H., Yu, Changhong, Palmer, Frank L., Patel, Purvi D., Ganly, Ian, Shah, Jatin P., Shaha, Ashok R., Boyle, Jay O., Kraus, Dennis H., Singh, Bhuvanesh, Wong, Richard J., Morris, Luc G., Kattan, Michael W., and Patel, Snehal G.
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SQUAMOUS cell carcinoma ,ORAL cancer risk factors ,ORAL cancer ,NOMOGRAPHY (Mathematics) ,PREOPERATIVE period ,CAVITY walls ,CANCER-related mortality ,ONCOLOGIC surgery ,PATIENTS ,PROGNOSIS - Abstract
BACKGROUND This study sought to develop prognostic tools that will accurately predict overall and cancer-related mortality and risk of recurrence in individual patients with oral cancer based on host and tumor characteristics. These tools would take into account numerous prognosticators beyond those covered by the traditional TNM (tumor-node-metastasis) staging system. METHODS Demographic, host, and tumor characteristics of 1617 patients with cancer of the oral cavity, who were treated primarily with surgery at a single-institution tertiary care cancer center between 1985 and 2009, were reviewed from a preexisting database. Recurrent disease was recorded in 509 patients (456 locoregional and 116 distant); 328 patients died of cancer-related causes, and 542 died of other causes. The median follow-up was 42 months (range, 1-300 months). The following variables were analyzed as predictors of prognosis: age, sex, race, alcohol and tobacco use, oral cavity subsite, invasion of other structures, comorbidity, tumor size, and clinical nodal status. The stepdown method was used to select the statistically most influential predictors for inclusion in the final nomogram for each outcome of interest. RESULTS The most influential predictors of both recurrence and cancer-specific mortality probability (CSMP) were tumor size, nodal status, subsite, and bone invasion. Nomograms were generated for prediction of overall survival (OS), CSMP, and locoregional recurrence-free probability (LRRFP). The nomograms were internally validated with an overfit-corrected predictive discrimination metric (concordance index) for OS of 67%, CSMP of 66%, and LRRFP of 60%. CONCLUSIONS Nomograms have been developed that can reasonably estimate OS, CSMP, and LRRFP based on specific tumor and host characteristics in patients with oral cancer. Cancer 2014;120:214-221. © 2013 American Cancer Society. [ABSTRACT FROM AUTHOR]
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- 2014
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9. Clinical ethics consultation in patients with head and neck cancer.
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Shuman, Andrew G., McCabe, Mary S., Fins, Joseph J., Kraus, Dennis H., Shah, Jatin P., and Patel, Snehal G.
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HEAD & neck cancer ,CANCER patients ,HEAD & neck cancer patients ,ETHICS ,INTERPERSONAL conflict - Abstract
Background The purpose of this study was to describe the impact of clinical ethics consultations among patients with head and neck cancer in order to better anticipate and manage clinical challenges. Methods A database was queried to identify patients with head and neck cancer for whom ethics consultation was performed at a comprehensive cancer center ( n = 14). Information from the database was verified via data abstraction and analyzed qualitatively and quantitatively. Results Common requests for ethics consultation involved code status (6 of 14) and withdrawal/withholding life-sustaining treatments (6 of 14). Common contextual features were interpersonal conflicts (6 of 14) and communication barriers (5 of 14). Airway management concerns were frequent (5 of 14). Whereas 21% of patients had do not resuscitate (DNR) orders before ethics consultation, 79% were DNR subsequently. Conclusion Ethics consultations among patients with head and neck cancer reflect distinctive complexities inherent to their disease, but are entirely consistent with global clinical ethical themes. Consideration of communication barriers, social isolation/stigma, symptom control, and airway management are critical. © 2012 Wiley Periodicals, Inc. Head Neck, 35: 1647-1651, 2013 [ABSTRACT FROM AUTHOR]
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- 2013
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10. Preliminary evaluation of the reliability and validity of the Shame and Stigma Scale in head and neck cancer.
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Kissane, David W., Patel, Snehal G., Baser, Raymond E., Bell, Rachel, Farberov, Maria, Ostroff, Jamie S., Li, Yuelin, Singh, Bhuvanesh, Kraus, Dennis H., and Shah, Jatin P.
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HEAD & neck cancer ,FUNCTIONAL assessment ,CRONBACH'S alpha ,QUALITY of life ,CANCER treatment ,SQUAMOUS cell carcinoma - Abstract
Background Facial disfigurement from head and neck cancer can lead to the development of shame and a perception of stigma. We sought to develop the Shame and Stigma Scale (SSS) to measure this. Items were administered to 104 patients with squamous cell carcinoma of the oral cavity, together with measures of quality of life and adaptation. Exploratory factor analysis and item response theory (IRT) models assessed its psychometric properties. Results A 20-item SSS had a Cronbach's alpha of 0.94 and 4 factors: shame with appearance, sense of stigma, regret, and speech/social concerns. These factors show satisfactory internal validity, convergent validity with the Functional Assessment of Cancer Therapy-General (FACT-G) and Functional Assessment of Cancer Therapy-Head and Neck (FACT-H&N), Demoralization Scale and Patient Health Questionnaire (PHQ) Depression, and divergent validity with the Social Desirability Scale. The items displayed desirable properties in factor-specific (IRT) models. Conclusion Further validation studies are worthwhile to confirm this factor structure, reliability, and validity, and generalizability to all head and neck cancers. © 2012 Wiley Periodicals, Inc. Head Neck, 2013 [ABSTRACT FROM AUTHOR]
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- 2013
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11. Selective Neck Dissection in Node-Positive Squamous Cell Carcinoma of the Head and Neck.
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Givi, Babak, Linkov, Gary, Ganly, Ian, Patel, Snehal G., Wong, Richard J., Singh, Bhuvanesh, Boyle, Jay O., Shaha, Ashok R., Shah, Jatin P., and Kraus, Dennis H.
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The article focuses on a study conducted to analyze the effectiveness of selective neck dissection (SND) in the detection of node-positive squamous cell carcinoma of the head and neck. Medical records from the year 2000 to 2010 of the patients suffering with cervical lymph node metastases and treated with SND were collected for the study. According to the results, SND was effective in the treatment when used with adjuvant radiotherapy or radio chemotherapy.
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- 2012
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12. New AJCC: How does it impact oral cancers?
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Zanoni, Daniella Karassawa and Patel, Snehal G.
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ORAL cancer , *TUMOR classification , *HEAD & neck cancer , *MOUTH tumors , *PROGNOSIS , *IMPACT of Event Scale , *RESEARCH funding - Abstract
Purpose Of Review: The objective of this article is to critically review the rationale for the changes in the staging of the oral cavity cancers.Recent Findings: After reviewing many recent studies about oral cancer and analyzing multi-institutional data for outcomes, the staging system was updated to include new knowledge of the disease and its biological behavior.Summary: This article reviews the changes in the staging of oral cavity cancers published in the 8th edition of the AJCC/UICC TNM cancer staging manual and discusses future directions. [ABSTRACT FROM AUTHOR]- Published
- 2020
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13. Survival outcomes after treatment of cancer of the oral cavity (1985-2015).
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Zanoni, Daniella Karassawa, Montero, Pablo H., Migliacci, Jocelyn C., Shah, Jatin P., Wong, Richard J., Ganly, Ian, and Patel, Snehal G.
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HEAD & neck cancer , *TREATMENT of oral cancer , *ORAL cancer , *SQUAMOUS cell carcinoma , *BIVARIATE analysis , *NECK dissection , *RADIOTHERAPY , *LONGITUDINAL method , *LYMPH nodes , *METASTASIS , *MOUTH tumors , *NECK , *PROGNOSIS , *RESEARCH funding , *TUMOR classification , *RETROSPECTIVE studies - Abstract
Objectives: To present treatment results of oral squamous cell carcinoma (OSCC) at a tertiary cancer care center from 1985 to 2015.Materials and Methods: A total of 2082 patients were eligible for this study. Main outcomes measured were overall survival (OS) and disease specific survival (DSS). Prognostic variables were identified with bivariate analyses using Kaplan-Meier curves and log-rank testing for comparison. A p-value < 0.05 was considered statistically significant and significant factors were entered into multivariate analysis. Median age was 62 years (16-100), 56% were men, 66% reported a history of tobacco use and 71% of alcohol consumption. The most common subsite was tongue (51%). Seventy-three percent of patients had cT1-2 and 71% had clinically negative necks (cN0). Surgery alone was performed in 1348 patients (65%), adjuvant postoperative radiotherapy in 608 patients (29%) and postoperative chemoradiation in 126 patients (6%). Neck dissection was performed in 920 patients with cN0, and in 585 patients with a clinically involved neck. The median follow-up was 37.6 months (range 1-382).Results: The 5-year OS and DSS were 64.4% and 79.3%, respectively. Age, comorbidities, margin status, vascular invasion, perineural invasion, AJCC 8th edition pT, and pN were independent prognostic factors of OS (p < 0.05). History of alcohol consumption, margin status, vascular invasion, perineural invasion, pT, and pN were independent prognostic factors of DSS (p < 0.05).Conclusion: pN stage is the most powerful and consistent predictor of outcome in patients with OSCC treated with primary surgery and appropriate adjuvant therapy. [ABSTRACT FROM AUTHOR]- Published
- 2019
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14. Do we need a different staging system for tongue and gingivobuccal complex squamous cell cancers?
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Gupta, Piyush, Migliacci, Jocelyn C., Montero, Pablo H., Zanoni, Daniella Karassawa, Shah, Jatin P., Patel, Snehal G., and Ganly, Ian
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CANCER treatment , *SQUAMOUS cell carcinoma , *SURGICAL therapeutics , *HEALTH outcome assessment , *PROGRESSION-free survival , *MEDICAL databases - Abstract
Objectives: To determine the need for a separate staging system for gingivobuccal complex squamous cell cancers (GBCSCC) based on 5-year overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) data from one institution.Patients and Methods: An Institutional Review Board (IRB)-approved retrospective analysis was performed on an oral cavity cancer patient database. Patients from 1985 to 2012 with primary surgical treatment for biopsy-proven squamous cell cancer (SCC) from either the oral tongue (TSCC Group) or gingivobuccal complex (GBCSCC Group), were selected as two separate subgroups. The clinicopathologic data were used to stage the patients based on the American Joint Committee on Cancer 7th edition. Survival outcomes including 5-year OS, RFS, and DSS were calculated and analyzed. A multivariate analysis was performed to identify if subsite was an independent predictor for the survival outcomes, adjusting for other variables. A p-value of less than .05 was considered statistically significant.Results: 936 patients with TSCC and 486 patients with GBCSCC were considered eligible for the analysis. Patients with GBCSCC were more likely to be older (p < .001) and presented with more advanced disease (p < .001) compared to patients with TSCC. Unadjusted hazard ratio (HR) suggested GBCSCC had poor OS compared to TSCC. However, after adjusting for other variables, the adjusted HR was not significant (p = .593). There was no difference in 5-year DSS or RFS in either of the study groups.Conclusion: With similar survival outcomes by stage, there is no justification for using a different staging system for GBCSCC. [ABSTRACT FROM AUTHOR]- Published
- 2018
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15. A novel tumor: Specimen index for assessing adequacy of resection in early stage oral tongue cancer.
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Montero, Pablo H., Palmer, Frank L., Shuman, Andrew G., Patel, Purvi D., Boyle, Jay O., Kraus, Dennis H., Morris, Luc G., Shah, Jatin P., Shaha, Ashok R., Singh, Bhuvanesh, Wong, Richard J., Ganly, Ian, and Patel, Snehal G.
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SURGICAL site , *TONGUE cancer , *ADJUVANT treatment of cancer , *COHORT analysis , *HEALTH outcome assessment , *RETROSPECTIVE studies - Abstract
Summary: Purpose: Surgical margin status frequently affects decisions regarding adjuvant treatment; however, reporting and interpretation of surgical margins is subject to considerable subjectivity because of many factors including the adequacy of resection. We developed a novel measure of the adequacy of surgical resection, the tumor: specimen index (TSI), and tested its utility at predicting clinical outcomes in a retrospective cohort study. Patients and methods: An institutional database was queried to identify previously untreated patients with T1 and T2 oral tongue cancer who underwent surgery during 1985–2009 (n =433). The TSI, a geometric mean representing the percentage of the surgical specimen that is occupied by the tumor in average single dimension, was calculated from the largest measured lengths, widths, and heights of the tumor in relation to the entire surgical specimen. Multivariate analyses of locoregional recurrence-free probability (LRRFP) and disease-specific survival (DSS) were performed with commonly accepted prognosticators in addition to TSI and surgical margins status. Results: The mean TSI was 41 (range 11–90; SD 14). Surgical margin status was associated with TSI; margins were negative in 84% of patients with TSI<45 and in 63% of patients with TSI⩾45 (p <0.001). TSI⩾45 was associated with worse LRRFP (57% vs 76%, p <0.001) and worse DSS (68% vs 85%, p <0.001). In a multivariate analysis that did not include TSI, surgical margin status independently predicted LRRFP (p =0.014) but not DSS. When TSI was included, only TSI, and not surgical margin status, was an independent predictor of both LRRFP (p =0.002) and DSS (p =0.011). Conclusion: The tumor: specimen index is an easily-calculated metric for estimating the adequacy of 3-dimensional resection in T1 and T2 oral tongue cancer that independently predicts oncologic outcomes. [Copyright &y& Elsevier]
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- 2014
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16. Outcomes of a head and neck cancer screening clinic.
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Shuman, Andrew G., McKiernan, Janet T., Thomas, Dorothy, Patel, Prateek, Palmer, Frank L., Shaffer, Brian T., Shah, Jatin P., Patel, Snehal G., and Boyle, Jay O.
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HEAD & neck cancer , *HEALTH outcome assessment , *FOLLOW-up studies (Medicine) , *SYMPTOMS , *MEDICAL records - Abstract
Summary: Objective: To describe an institutional experience conducting an annual free head and neck (H&N) cancer screening clinic. Specific aims included: (1) identifying factors predicting which individuals will have findings suspicious for malignancy; and (2) evaluating potential barriers to subsequent follow-up among patients with suspicious findings. Materials and methods: This retrospective cohort study involved individuals presenting to an annual H&N cancer screening clinic (2001–2012). Original screening clinic data and electronic medical records were reviewed. Descriptive and comparative statistics were utilized in order to address the study aims. Results: Of 1573 participants, 325 (21%) had abnormal findings on screening, of which 183 (12%) had findings suspicious for cancer. No demographic factors predicted a suspicion for cancer. The presence of patient-reported symptoms (16% vs. 8%; p <0.001) were significantly associated with a suspicion for cancer. Only 20% of individuals with a suspicion for cancer returned to our institution for recommended follow-up. Patients who did not complain of symptoms were less likely to return for follow-up (2% vs. 36%; p <0.001). Of the patients who returned for follow-up evaluation, malignancies were diagnosed in three patients. Conclusion: Few individuals presenting to a H&N cancer screening clinic will have a malignancy detected, and barriers may influence patients’ likelihood to present for subsequent evaluation. Due to self-selection among patients presenting for screening, traditional risk factors may not be associated with the likelihood of detecting a suspicion for H&N cancer. Head and neck cancer screening clinics should thus target patients at high risk, and attempt to ensure appropriate follow-up thereafter. [Copyright &y& Elsevier]
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- 2013
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17. Distant metastasis in oral squamous cell carcinoma: Does the neutrophil-to-lymphocyte ratio act as a surrogate of the host immune status?
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Zanoni, Daniella Karassawa, Valero, Cristina, McGill, Marlena R., Montero, Pablo H., Shah, Jatin P., Wong, Richard J., Ganly, Ian, and Patel, Snehal G.
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NEUTROPHIL lymphocyte ratio , *SQUAMOUS cell carcinoma , *IMMUNITY , *METASTASIS , *PROGNOSIS - Abstract
• 1369 patients with oral cavity cancer operated between 1998 and 2015 were studied. • Number of metastatic nodes and extranodal extension predicted distant failure. • Neutrophil-to-lymphocyte ratio was an independent predictor of distant metastasis. • Tumor and host factors should be considered when assessing distant metastasis risk. Distant metastasis (DM) is an important prognostic factor for oral squamous cell carcinoma (OSCC). The aim of this study is to evaluate the influence of host and tumor factors in development of DM. After IRB approval, 1369 patients with OSCC undergoing primary surgery were eligible for the study. The primary endpoint was the development of distant metastasis (DM). Patients were pathologically staged according to the American Joint Committee on Cancer, 8th Edition. Pre-operative peripheral blood counts were used to calculate neutrophil-to-lymphocyte ratio (NLR). Median follow-up was 39 months (range 1–221). DM were identified in 126 patients during follow-up. When analyzed as a time-dependent covariate, neck recurrence (NR) was a significant predictor of DM (HR 16.35, 95% CI: 11.39–23.47, p < 0.001). NLR, margin status, vascular invasion, perineural invasion (PNI), grade, pT, number of metastatic lymph nodes, level IV involvement, and extra nodal-extension (ENE) were also significant. In multivariable analysis, NLR, margins, PNI, number of metastatic lymph nodes, and ENE maintained independent predictive capacity. Patients with NLR ≥ 5.7 were 3 times more likely to develop DM compared to NLR ≤ 2.9 (95% CI: 1.74–5.59, p < 0.001), patients with ≥ 5 metastatic lymph nodes were 2 times more likely to develop DM (95% CI: 1.18–3.60, p = 0.011), and those with ENE were 4 times more likely (95% CI: 2.67–8.20, p < 0.001) when compared to pNx/pN0 patients. NLR, number of metastatic lymph nodes, and ENE were the strongest independent predictors of DM in OSCC treated with primary surgery and appropriate adjuvant therapy. [ABSTRACT FROM AUTHOR]
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- 2022
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18. Distant metastasis in oral squamous cell carcinoma: Does the neutrophil-to-lymphocyte ratio act as a surrogate of the host immune status?
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Zanoni, Daniella Karassawa, Valero, Cristina, McGill, Marlena R, Montero, Pablo H, Shah, Jatin P, Wong, Richard J, Ganly, Ian, and Patel, Snehal G
- Abstract
Objectives: Distant metastasis (DM) is an important prognostic factor for oral squamous cell carcinoma (OSCC). The aim of this study is to evaluate the influence of host and tumor factors in development of DM.Materials and Methods: After IRB approval, 1369 patients with OSCC undergoing primary surgery were eligible for the study. The primary endpoint was the development of distant metastasis (DM). Patients were pathologically staged according to the American Joint Committee on Cancer, 8th Edition. Pre-operative peripheral blood counts were used to calculate neutrophil-to-lymphocyte ratio (NLR).Results: Median follow-up was 39 months (range 1-221). DM were identified in 126 patients during follow-up. When analyzed as a time-dependent covariate, neck recurrence (NR) was a significant predictor of DM (HR 16.35, 95% CI: 11.39-23.47, p < 0.001). NLR, margin status, vascular invasion, perineural invasion (PNI), grade, pT, number of metastatic lymph nodes, level IV involvement, and extra nodal-extension (ENE) were also significant. In multivariable analysis, NLR, margins, PNI, number of metastatic lymph nodes, and ENE maintained independent predictive capacity. Patients with NLR ≥ 5.7 were 3 times more likely to develop DM compared to NLR ≤ 2.9 (95% CI: 1.74-5.59, p < 0.001), patients with ≥ 5 metastatic lymph nodes were 2 times more likely to develop DM (95% CI: 1.18-3.60, p = 0.011), and those with ENE were 4 times more likely (95% CI: 2.67-8.20, p < 0.001) when compared to pNx/pN0 patients.Conclusions: NLR, number of metastatic lymph nodes, and ENE were the strongest independent predictors of DM in OSCC treated with primary surgery and appropriate adjuvant therapy. [ABSTRACT FROM AUTHOR]- Published
- 2021
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