1. Risk factors for human papillomavirus‐positive nonoropharyngeal squamous cell carcinoma
- Author
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Windon, Melina J, D'Souza, Gypsyamber, Waterboer, Tim, Rooper, Lisa, Westra, William H, Troy, Tanya, Pardoll, Drew, Tan, Marietta, Yavvari, Siddhartha, Kiess, Ana P, Miles, Brett, Mydlarz, Wojciech K, Ha, Patrick K, Bender, Noemi, Eisele, David W, and Fakhry, Carole
- Subjects
Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Digestive Diseases ,Infectious Diseases ,Cancer ,Clinical Research ,HIV/AIDS ,Cervical Cancer ,Prevention ,Sexually Transmitted Infections ,Dental/Oral and Craniofacial Disease ,Alphapapillomavirus ,Carcinoma ,Squamous Cell ,Head and Neck Neoplasms ,Humans ,Oropharyngeal Neoplasms ,Papillomavirus Infections ,Prospective Studies ,Risk Factors ,biomarkers ,head and neck cancer ,HPV ,oropharyngeal cancer ,survival ,Clinical Sciences ,Dentistry ,Otorhinolaryngology ,Clinical sciences - Abstract
BackgroundHuman papillomavirus (HPV)-positive oropharyngeal cancer (HPV-OPC) is distinct from HPV-unassociated head and neck cancer. However, whether risk factors for HPV-positive oropharyngeal and nonoropharyngeal squamous cell cancer are the same is unclear.MethodsIncident cases of HPV-positive head and neck cell cancer and matched non-cancer controls were enrolled in a multi-institutional, prospective study examining risk factors, biomarkers, and survival.ResultsHPV-nonOPC (n = 20) were more likely to be ever smokers than controls (n = 80, OR 3.49, 95%CI 1.11-10.9) and HPV-OPC (n = 185, OR 3.28, 95%CI 1.10-10.2). Compared with HPV-OPC, HPV-nonOPC were less likely to have had over 3 oral sexual partners (OR 0.29, 95%CI 0.06-0.9), more likely to have multimorbidity (OR 3.30, 95%CI 1.04-10.5), and less likely to have antibodies to HPV16 E6 (90% vs 28%, OR 0.05, 95%CI 0.02-0.2). HPV-nonOPC had worse 4-year OS (77% vs 96%, P = .001) and RFS (69% vs 94%, P
- Published
- 2020