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The use of new technology and mathematics to study the systems of nature is one of the most significant scientific trends of the century. Driven by the need for more precise scientific understand, advances in automated measurement are providing rich new sources of biological and physiological data. This data provides information with which to create mathematical models of increasing sophistication and realism - models that can emulate the performance of biological and physiological systems with sufficient accuracy to advance our understanding of living systems and disease mechanisms. New measurement and modelling methods set the stage for control and systems theory to play their role in seeking out the mechanisms and principles that regulate life. It is of inestimable importance for the future of control as a discipline that this role is performed in the correct manner. If we handle the area wisely then living systems will present a seemly boundless range of important new problems - just as physical and engineering systems have done in previous centuries. But there is a crucial difficulty. Faced with a bewildering array of choices in an unfamiliar area, how does a researcher select a worthwhile and fruitful problem? This lecture is an attempt to help by offering a control oriented guide to the labyrinthine world of biology/physiology and the control research opportunity that it holds.

An active control system is described for the automatic alignment of the mirrors in a two-beam interferometer. From an initial unaligned position the active control system determines the degree of misalignment and adjusts the relative mirror positions accordingly. An embodiment of the system is described for a Michelson interferometer in which one of the mirrors is mounted upon three piezoelectric transducers PZT arranged so that they can both tilt and retard the mirror. Laser sources and corresponding photodetectors are also incorporated such that a control system can use the PZT actuators to produce a series of mirror movements relative to the fixed mirror and give a set of two-dimensional diffraction patterns one for each of the laser photodetectors. Amplitude and phase information is extracted from these patterns which enables the control system to align the mirrors such that the diffraction pattern maxima is at the center of the instrument central photodetector. In a further stage of the control algorithm, the alignment accuracy is refined using information from the laser photodetectors during retardation of the mirror. In this manner, the initial mirror alignment, maintaining that alignment during retardation and diagnosis of possible misalignment, become part of a single active control technology for instrument alignment.