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Your search keyword '"Wen, Chong-Wei"' showing total 1 results
Start Over Author "Wen, Chong-Wei" Topic halogen compounds
1 results on '"Wen, Chong-Wei"'

1. Synthesis, characterization, and NF-κB pathway inhibition of 1-halogenated sinomenine derivatives.

Author

Tang, Jian, Zhang, Rong, Xu, Xiu-Quan, Wen, Chong-Wei, Jin, Yong-Sheng, Wu, Qiu-Ye, and Chen, Hai-Sheng

Subjects
CHEMICAL derivatives, CELL lines, HALOGENATION, HALOGEN compounds, DERIVATIZATION
Abstract

A series of 1-halogenated sinomenine derivatives was designed and prepared. All synthesized derivatives were structurally confirmed by ESI-MS, PMR. The inhibition of the NF-κB pathway in vitro was evaluated with pNF-κB-luc cell lines. The derivatives 5b, 6a, 6c, and 7a inhibited NF-κB action with IC values lower than that of sinomenine. [ABSTRACT FROM AUTHOR]

Published
2013
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