1. Role for proteases and HLA-G in the pathogenicity of influenza A viruses
- Author
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Foucault, Marie-Laure, Moules, Vincent, Rosa-Calatrava, Manuel, and Riteau, Béatrice
- Subjects
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INFLUENZA A virus, H5N1 subtype , *PROTEOLYTIC enzymes , *PANDEMICS , *H1N1 influenza , *HLA histocompatibility antigens , *COMMUNICABLE diseases , *HOST-virus relationships , *HEMAGGLUTININ - Abstract
Abstract: Influenza is one of the most common infectious diseases in humans occurring as seasonal epidemic and sporadic pandemic outbreaks. The ongoing infections of humans with avian H5N1 influenza A viruses (IAV) and the past 2009 pandemic caused by the quadruple human/avian/swine reassortant (H1N1) virus highlights the permanent threat caused by these viruses. This review aims to describe the interaction between the virus and the host, with a particular focus on the role of proteases and HLA-G in the pathogenicity of influenza viruses. [Copyright &y& Elsevier]
- Published
- 2011
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