1. Epidemiological guideline influence on the therapeutic trend and patient outcome of uterine cervical cancer in Japan: Japan society of gynecologic oncology guideline evaluation committee project.
- Author
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Shigeta S, Shida M, Nagase S, Ikeda M, Takahashi F, Shibata T, Yamagami W, Katabuchi H, Yaegashi N, Aoki D, and Mikami M
- Subjects
- Adult, Aged, Aged, 80 and over, Chemotherapy, Adjuvant standards, Chemotherapy, Adjuvant statistics & numerical data, Chemotherapy, Adjuvant trends, Evidence-Based Medicine standards, Evidence-Based Medicine statistics & numerical data, Evidence-Based Medicine trends, Female, Guideline Adherence statistics & numerical data, Gynecology standards, Gynecology statistics & numerical data, Humans, Hysterectomy standards, Hysterectomy statistics & numerical data, Hysterectomy trends, Japan epidemiology, Medical Oncology standards, Medical Oncology statistics & numerical data, Middle Aged, Neoadjuvant Therapy standards, Neoadjuvant Therapy statistics & numerical data, Neoplasm Staging, Practice Guidelines as Topic, Practice Patterns, Physicians' standards, Practice Patterns, Physicians' statistics & numerical data, Radiotherapy, Adjuvant standards, Radiotherapy, Adjuvant statistics & numerical data, Radiotherapy, Adjuvant trends, Registries statistics & numerical data, Societies, Medical standards, Survival Analysis, Survival Rate trends, Treatment Outcome, Uterine Cervical Neoplasms diagnosis, Gynecology trends, Medical Oncology trends, Practice Patterns, Physicians' trends, Uterine Cervical Neoplasms mortality, Uterine Cervical Neoplasms therapy
- Abstract
Objective: The Japan Society of Gynecologic Oncology published its first clinical guidelines for uterine cervical cancer in 2007 which has been revised twice in 2011 and 2017. The aim of this study was to investigate the influence of the first guideline publication on the therapeutic trend and patient outcome by analyzing uterine cervical cancer cases registered to the cancer registry organized by the Japan Society of Obstetrics and Gynecology., Methods: Data of uterine cervical cancer cases registered to the cancer registry from 2000 to 2012 were provided. Epidemiological and clinical trend were analyzed by the Chi-squared test with subsequent standardized residual analysis. Overall survival among the patients registered between 2004 and 2009 was analyzed using the Fine and Gray competing risk model., Results: 68,707 cases were registered during the study period. A trend analysis revealed that the guideline publication may have led to a decrease in neoadjuvant chemotherapy in parallel with an increase in radiation therapy mainly in stage II and III patients undergoing primary treatment. A survival analysis indicated that the introduction of the guideline may have improved overall survival among stage III uterine cervical cancer patients, even though a significant difference was not observed in all of the cases., Conclusions: This study demonstrated the potential influence of the guideline publication on the clinical trend and patient outcome. As this is the first assessment of the guideline for uterine cervical cancer in Japan, continuous evaluation is necessary to further comprehend the significance of this guideline., Competing Interests: Declaration of Competing Interest The authors have no conflict of interest to disclose regarding to this study., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2020
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