1. Ochratoxin A: its impact on poultry gut health and microbiota, an overview
- Author
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Lin Yang, Yongwen Zhu, Ye Yang, Feng Peishi, Wence Wang, Macheng Li, and Shuangshuang Zhai
- Subjects
Ochratoxin A ,tight junction ,MICROBIOLOGY AND FOOD SAFETY ,Gut flora ,digestive system ,SF1-1100 ,Microbiology ,Absorption rate ,03 medical and health sciences ,chemistry.chemical_compound ,Immunity ,Animals ,Barrier integrity ,Mycotoxicosis ,Mycotoxin ,030304 developmental biology ,0303 health sciences ,biology ,gut microbiota ,Microbiota ,poultry ,digestive, oral, and skin physiology ,0402 animal and dairy science ,04 agricultural and veterinary sciences ,General Medicine ,biology.organism_classification ,Ochratoxins ,040201 dairy & animal science ,immunity ,Gastrointestinal Microbiome ,Animal culture ,chemistry ,Gut immunity ,Animal Science and Zoology ,Chickens ,ochratoxin A - Abstract
Ochratoxin A (OTA) is a widespread mycotoxin, that has strong thermal stability, and is difficult to remove from feed. OTA is nephrotoxic, hepatotoxic, teratogenic, immunotoxic, and enterotoxic to several species of animals. The gut is the first defense barrier against various types of mycotoxins present in feed that enter the body, and it is closely connected to other tissues through enterohepatic circulation. Compared with mammals, poultry is more sensitive to OTA and has a lower absorption rate. Therefore, the gut is an important target tissue for OTA in poultry. This review comprehensively discusses the role of OTA in gut health and the gut microbiota of poultry, focusing on the effect of OTA on digestive and absorptive processes, intestinal barrier integrity, intestinal histomorphology, gut immunity, and gut microbiota. According to the studies described to date, OTA can affect gut dysbiosis, including increasing gut permeability, immunity, and bacterial translocation, and can eventually lead to gut and other organ injury. Although there are many studies investigating the effects of OTA on the gut health of poultry, further studies are needed to better characterize the underlying mechanisms of action and develop preventative or therapeutic interventions for mycotoxicosis in poultry., Graphical abstract
- Published
- 2021